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Molecular Diagnostics

$This photomicrograph of a Gram-stained urethral smear specimen, reveals some of the histopathology in an acute case of gonococcal urethritis, caused by the Gram-negative bacterium, Neisseria gonorrhoeae. (Image courtesy of [U.S.] Centers for Disease Control and Prevention\'s Public Health Image Library)$

Diagnostic Test Identifies Resistance Mutation that Enables Use of Inexpensive, Single Dose Gonorrhea Drug

By detecting the mutated gene responsible for resistance to the drug ciprofloxacin, it is possible to identify gonorrhea patients who can be cured by a single oral dose of this drug. More...
19 Aug 2020

Transmission electron microscope image of SARS-CoV-2 (2019-nCoV), the virus that causes COVID-19, isolated from a patient in the U.S.A. Virus particles are shown emerging from the surface of cells cultured in the laboratory. (Image courtesy of National Institute of Allergy and Infectious Diseases via Wikimedia Commons)

Panel of Five Serum Biomarkers Identifies COVID-19 Patients at High Risk to Develop Serious Complications

A recent paper suggested that elevated levels of five serum biomarkers could be used to identify COVID-19 patients who are at high risk for serious complications or death. More...
18 Aug 2020

$Graphic representation of how the urinary tract microbiome in older women exhibits host genetic and environmental influences (Photo courtesy of King\'s College London).$

Host Genetic, Environmental Factors Influence Urinary Tract Microbiome

The urinary microbiome is a relatively unexplored niche that varies with gender. Urinary microbes, especially in aging populations, are associated with morbidity. Both genetic and environmental factors influence the makeup of the urinary tract microbiome of older women. More...
14 Aug 2020

Ring-form trophozoites of Plasmodium falciparum and a white blood cell in a thick blood film (Photo courtesy of Medical Care Development International).

Automated Malaria Diagnosis Enhanced by Deep Neural Networks

Plasmodium falciparum malaria remains one of the greatest global health burdens with over 228 million cases globally in 2018. In that year there were approximately 405,000 deaths due to malaria worldwide, with the African region accounting for 93% of these deaths, mostly among children. More...
14 Aug 2020

$Abnormal accumulation of tau protein in neuronal cell bodies (arrow) and neuronal extensions (arrowhead) in the neocortex of a patient who had died with Alzheimer\'s disease (Photo courtesy of Wikimedia Commons)$

Phosphorylated-Tau Blood Test Identifies Asymptomatic Alzheimer’s Disease

A blood test that determines circulating levels of the Alzheimer's disease (AD) biomarker protein phospho-tau217 (p-tau217) was found to distinguish AD from other neurodegenerative diseases, with significantly higher accuracy than established plasma- and MRI-based biomarkers, and its performance was not significantly different from key cerebral spinal fluid (CSF)- or PET-based measurements. More...
10 Aug 2020

Image: The NovaSeq 6000 Sequencing System offers high-throughput sequencing across a broad range of applications (Photo courtesy of Illumina).

Somatic Evolution Identified in Non-Neoplastic IBD-Affected Colon

Inflammatory bowel disease (IBD) is a debilitating disease characterized by repeated flares of intestinal inflammation. The two major subtypes of IBD, Crohn’s disease (CD) and ulcerative colitis (UC) are distinguished by the location, continuity, and nature of the inflammatory lesions. More...
06 Aug 2020

Image: This image depicts a DNA molecule that is methylated on both strands on the center cytosine. The two white spheres represent methyl groups (Photo courtesy of Wikimedia Commons)

Liquid Biopsy Test Accurately Detects Cancer in Nonsymptomatic Individuals

A liquid biopsy test that analyzes levels of circulating tumor DNA methylation detected cancer in nonsymptomatic individuals up to four years before tumors were found by current diagnostic methods. More...
06 Aug 2020

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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.