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Molecular Diagnostics

Image: A fundus photo showing intermediate age-related macular degeneration (Photo courtesy of National Eye Institute).

Genes Associated with Age-Related Macular Degeneration Identified

Age-Related Macular Degeneration (AMD) is a complex disease influenced by yet-to-be-understood mix of genetic and behavioral factors. Smoking increases the risk of developing the disease, while eating leafy greens and fish reduces it. More...
26 Feb 2019
Image: The cf-DNA/cf-RNA Preservative tubes (Photo courtesy of Norgen Biotek).

Storage Tubes for Analysis of Circulating NAs Evaluated

Circulating nucleic acids such as microRNAs (miRNAs) and cell-free DNA (cfDNA) have become increasingly important in serving as potential novel biomarkers for a variety of human diseases. More...
26 Feb 2019
Image: The Nextera DNA Library Preparation Kit (Photo courtesy of Illumina).

Gene Missense Variant Associated with Crohn's Disease

Gene-microbiome interactions are important in etiology and pathogenesis of inflammatory bowel disease, a chronic inflammatory disorder of the gastrointestinal tract consisting of Crohn’s disease and ulcerative colitis. More...
21 Feb 2019
Image: Halosperm is an in vitro diagnostic kit that allows the measurement of DNA fragmentation in a fast, easy, and reproducible manner, without the need for complex laboratory equipment (Photo courtesy of Halotech DNA SL).

Markers in Male Reproductive Impairments Causing Miscarriages

Recurrent pregnancy loss, (RPL) affecting 1% to 2% of couples, is defined as ≥3 consecutive pregnancy losses before 20-week' gestation. Women with RPL are routinely screened for etiological factors, but routine screening of male partners is not currently recommended. More...
21 Feb 2019
Image: The Affymetrix high-resolution microarray scanner 3000 (Photo courtesy of Thermo Fisher Scientific).

MicroRNAs Provide Clues in Primary CNS Lymphoma

Primary central nervous system lymphoma (PCNSL), a rare subgroup of diffuse large B-cell lymphoma (DLBCL) arising in the central nervous system (CNS), is an aggressive malignant variant of nodal non-Hodgkin lymphoma (NHL). More...
20 Feb 2019
Image: A graphical interpretation of cancer-associated circular RNAs catalogued across tumor types (Photo courtesy of University of Michigan).

Cancer-Associated Circular RNAs Catalogued Across Tumors

Circular RNA is a type of RNA which, unlike the better known linear RNA, forms a covalently closed continuous loop, i.e., in circular RNA the 3' and 5' ends normally present in an RNA molecule have been joined together. More...
18 Feb 2019
Image: Blood filled tubes used to preserve and stabilize cell-free DNA are also used in the PreSeek screening test (Photo courtesy of Streck).

Non-Invasive Prenatal Sequencing Designed for Multiple Mendelian Monogenic Disorders

Current non-invasive prenatal screening is targeted toward the detection of chromosomal abnormalities in the fetus. However, screening for many dominant monogenic disorders associated with de novo mutations is not available, despite their relatively high incidence. More...
14 Feb 2019
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