Magnetic Microneedle Array Robots to Revolutionize Tissue Slicing and Cultivation
|
By LabMedica International staff writers Posted on 01 Aug 2024 |
|
The cultivation of patient-derived tissues in vitro is essential for accurate diagnosis, targeted treatments, and advancements in tissue engineering. However, traditional methods of tissue slicing and cultivation often do not meet the clinical needs. Addressing this gap, a groundbreaking method has been developed that incorporates a controllable histotomy technique using hierarchical magnetic microneedle array robots. This innovation not only enhances tissue analysis capabilities but also paves the way for personalized medicine and the development of more effective therapies. As this technology evolves, it is anticipated to significantly impact biomedical research and clinical practices.
A team from Nanjing Drum Tower Hospital (Nanjing, China) has pioneered this innovative tissue slicing and cultivation method that promises to transform how primary tissues are managed in medical settings. Described in a research article published in Engineering, the method employs a three-dimensional printed slicing device with a mortise-tenon structure and a pagoda-shaped microneedle array scaffold loaded with magnetic particles. The multilayered structure of the microneedles ensures stable fixation of tissue samples during slicing, preventing slippage. Additionally, the encapsulated magnetic microneedle fragments convert tissue sections into biohybrid microrobots that can be magnetically manipulated for separation, transport, and dynamic culture.
This method was tested with primary pancreatic cancer tissues, which were segmented into small sections and cultured in multilayered microfluidic chips for comprehensive drug screening. The outcomes are promising for clinical application, marking a substantial advancement in the field of precision medicine. The research article also outlines potential enhancements, such as automating the tissue sectioning process and increasing the throughput of the microtomy device. Going forward, the researchers see potential applications of this technology extending beyond cancer to include various types of patient-derived tissues, potentially revolutionizing long-term tissue cultivation and monitoring.
“The development of this controllable histotomy technique marks a significant advancement in the field of tissue engineering and drug screening,” said Jiaming Wu, the editor of Engineering. “By leveraging the capabilities of magnetic microneedle array robots, researchers have been able to create a more efficient and precise method for tissue manipulation and analysis.”
Related Links:
Nanjing Drum Tower Hospital
 Test.jpg)
Latest Pathology News
- New Test Diagnoses High-Risk Childhood Brain Tumors
- Informatics Solution Elevates Laboratory Efficiency and Patient Care
- Microfluidic Device Assesses Stickiness of Tumor Cells to Predict Cancer Spread
- New AI Tool Outperforms Previous Methods for Identifying Colorectal Cancer from Tissue Sample Analysis
- New Technique Predicts Aggressive Tumors Before They Metastasize
- Butterfly Wings-Inspired Imaging Technique Enables Faster Cancer Diagnosis
- Machine Learning Tool Enables AI-Assisted Diagnosis of Immunological Diseases
- AI-Driven Tool to Accelerate Cancer Diagnosis
- Revolutionary AI Tool Transforms Disease Visualization
- Novel Dataset of Plasma Cells to Aid Diagnosis of Multiple Myeloma
- New Metabolite Detection Method Using DNA Sequencing Could Transform Diagnostics
- AI-Powered Pathology Solutions Accurately Predict Outcomes for HER2-Targeted Therapy in Metastatic CRC
- Cutting-Edge Medical Device Purifies and Concentrates Urine for Rapid Cancer Diagnosis
- Blood Test Measures Lipoprotein (a) in Molar Units for Better Cardiovascular Risk Assessment
- Long-Read Sequencing to Improve Diagnosis Rate of Rare Diseases
- AI Enhances Cervical Cancer Detection
Channels
Clinical Chemistry
view channel
Paper-Based Device Boosts HIV Test Accuracy from Dried Blood Samples
In regions where access to clinics for routine blood tests presents financial and logistical obstacles, HIV patients are increasingly able to collect and send a drop of blood using paper-based devices... Read more
AI-Powered Raman Spectroscopy Method Enables Rapid Drug Detection in Blood
Accurately monitoring drug levels in the blood is essential for effective treatment, particularly in the management of cardiovascular diseases. Traditional techniques for monitoring blood drug levels often... Read more
Novel LC-MS/MS Assay Detects Low Creatinine in Sweat and Saliva
Timely and accurate monitoring of renal function is essential for managing patients at risk of acute kidney injury (AKI), which affects about 12% of hospitalized patients and up to 57% of ICU patients.... Read more
Biosensing Technology Breakthrough Paves Way for New Methods of Early Disease Detection
Nanopores are tiny openings that can detect individual molecules as they pass through, making them ideal for analyzing biomolecules like DNA and proteins. However, detecting proteins at extremely low ... Read moreMolecular Diagnostics
view channel
Portable Blood-Based Device Detects Colon Cancer
Colon cancer is the second leading cause of cancer-related deaths in the U.S., yet it is highly treatable when detected at an early stage. Traditional colonoscopy screenings, although effective, are unpleasant,... Read more
New DNA Test Diagnoses Bacterial Infections Faster and More Accurately
Antimicrobial resistance has emerged as a significant global health threat, causing at least one million deaths annually since 1990. The Global Research on Antimicrobial Resistance (GRAM) Project warns... Read more
Innovative Bio-Detection Platform Improves Early Cancer Screening and Monitoring
Cancer remains one of the leading causes of death globally, underscoring the critical need for more advanced, efficient, and early detection methods. Circulating tumor cells (CTCs) are cells that have... Read more
Blood Test Could Help More Women Survive Aggressive Triple Negative Breast Cancer
Cancer research shows that over 90% of women diagnosed with breast cancer at its earliest stage survive for five years or more. However, this survival rate dramatically decreases to just 30% when the cancer... Read moreHematology
view channel
Non-Invasive Prenatal Test for Fetal RhD Status Demonstrates 100% Accuracy
In the United States, approximately 15% of pregnant individuals are RhD-negative. However, in about 40% of these cases, the fetus is also RhD-negative, making the administration of RhoGAM unnecessary.... Read more
WBC Count Could Predict Severity of COVID-19 Symptoms
The global health crisis caused by the SARS-CoV-2 virus continues to impact millions of people worldwide, with many experiencing persistent symptoms months after the initial diagnosis. Cognitive impairment... Read more
New Platelet Counting Technology to Help Labs Prevent Diagnosis Errors
Accurate platelet count testing is a significant challenge for laboratories. Inaccurate results can lead to misdiagnosis, missed diagnoses, and delayed treatment for a variety of potentially fatal conditions,... Read more
Streamlined Approach to Testing for Heparin-Induced Thrombocytopenia Improves Diagnostic Accuracy
Heparin-induced thrombocytopenia (HIT), a serious side effect of the blood thinner heparin, is difficult to diagnose because thrombocytopenia, or low platelet count, can be caused by a variety of factors... Read moreImmunology
view channel
Cerebrospinal Fluid Test Predicts Dangerous Side Effect of Cancer Treatment
In recent years, cancer immunotherapy has emerged as a promising approach where the patient's immune system is harnessed to fight cancer. One form of immunotherapy, called CAR-T-cell therapy, involves... Read more
New Test Measures Preterm Infant Immunity Using Only Two Drops of Blood
Preterm infants are particularly vulnerable due to their organs still undergoing development, which can lead to difficulties in breathing, eating, and regulating body temperature. This is especially true... Read more
Simple Blood Test Could Help Choose Better Treatments for Patients with Recurrent Endometrial Cancer
Endometrial cancer, which develops in the lining of the uterus, is the most prevalent gynecologic cancer in the United States, affecting over 66,000 women annually. Projections indicate that in 2025, around... Read more
Microbiology
view channel
Gastrointestinal Panel Delivers Rapid Detection of Five Common Bacterial Pathogens for Outpatient Use
Acute infectious gastroenteritis results in approximately 179 million cases each year in the United States, leading to a significant number of outpatient visits and hospitalizations. To address this, a... Read more
Rapid PCR Testing in ICU Improves Antibiotic Stewardship
A collaborative study led by the University of Plymouth (Devon, UK) has shown that rapid polymerase chain reaction (PCR) testing in the intensive care unit (ICU) improved antibiotic stewardship compared... Read more
Technology
view channel
POC Paper-Based Sensor Platform to Transform Cardiac Diagnostics
Cardiovascular diseases continue to be the leading cause of death worldwide, accounting for over 19 million fatalities annually. Early detection of myocardial infarction (MI), commonly known as a heart... Read more
Study Explores Impact of POC Testing on Future of Diagnostics
In today’s rapidly changing world, having quick and accurate access to medical information is more crucial than ever. Point-of-Care Diagnostics (PoC-D) and Point-of-Care Testing (PoC-T) are making this... Read more
Low-Cost, Fast Response Sensor Enables Early and Accurate Detection of Lung Cancer
Cancer biomarkers are valuable tools for early diagnosis as their concentration in body fluids, such as serum, can be measured to detect the disease at an earlier stage. Additionally, serum levels of these... Read more
Industry
view channel
CACLP 2025 Unites Global Innovators in IVD Industry
CACLP (Shanghai, China) will be holding the 22nd China International In Vitro Diagnostic Expo, the largest and most influential gathering of the IVD industry in China, 22-24 March 2025 at the Hangzhou... Read more
Bio-Rad to Acquire Digital PCR Developer Stilla Technologies
Bio-Rad Laboratories (Hercules, CA, USA) has entered into a binding offer to purchase all equity interests in Stilla Technologies (Villejuif, France). The acquisition remains subject to consultation with... Read more
