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Pathology

Image: The SimulToF matrix assisted laser desorption/ionization time of flight mass spectrometer (Photo courtesy of Virgin Instruments).

Protein Signature Associated with Outcome in Metastatic Melanoma

Clinical results in metastatic melanoma with the antibodies nivolumab and pembrolizumab to anti– programmed cell death protein 1 (PD-1) have led to clinically and statistically significant improvements in progression-free and overall survival compared to alternative first- and second-line therapies. More...
10 Jan 2018
Image: The BOND-MAX fully automated immunohistochemical (IHC) and in situ hybridization (ISH) stainer (Photo courtesy of Leica Biosystems).

Prognostic Biomarker Found for Endometrial Cancer

Endometrial cancer (EC) is a major health concern due to its rising incidence. Whilst early stage disease is generally cured by surgery, advanced EC has a poor prognosis with limited treatment options, and altered energy metabolism is a hallmark of malignancy. More...
08 Jan 2018
Image: The 3D Gene microarray platform (Photo courtesy of Toray Industries).

Nanowire Technology Developed to Detect Cancer Biomarkers in Urine

Analyzing microRNAs (miRNAs) within urine extracellular vesicles (EVs) is important for realizing miRNA-based, simple, and noninvasive early disease diagnoses and timely medical checkups. More...
04 Jan 2018
Image: The High Sensitivity Large Fragment Analysis Kit is used for the automated sizing and quantification of large DNA fragments and smears (Photo courtesy of Advanced Analytical Technologies).

Biomarker Detects Fatal Breast Cancer One Year Earlier

DNA methylation is the addition of a methyl group to DNA, which often affects gene expression. Aberrant DNA methylation is common in human tumors and methylation changes occur very early in breast cancer development. More...
03 Jan 2018
Image: A photomicrograph of a cervical cancer biopsy. Many squamous cells show dark nuclei surrounded by a clear halo. These are koilocytes and indicative of human papillomavirus (HPV) infection (Photo courtesy of Newcastle University).

HPV Test with Cytology Adds Little Diagnostic Value

The main goal of cervical screening programs is to detect and treat precancer before cancer develops. Human papillomavirus (HPV) testing is more sensitive than cytology for detecting precancer. More...
03 Jan 2018
Image: Genetic testing for detecting high-risk prostate cancer (Photo courtesy of Dr. David Samadi/Oncotype).

Genetic Test Recommended for Inherited Prostate Cancer

To date, there have been few recommendations to guide physicians about when to offer men genetic consultation for prostate cancer risk. A subset of prostate cancers, about 10%-15% of all prostate cancer are inherited and that at least some of the genes that confer the inherited risk are known and testable. More...
26 Dec 2017
Image: The Guardant360 kit for biopsy-free tissue sequencing for cancer and the PlasmaSelect 64 specimen collection kit (Photo courtesy of Guardant Health and Personal Genome Diagnostics).

Significant Disparities Found between Liquid Biopsy Providers

Liquid biopsy is a new and noninvasive alternative to tumor tissue sequencing, and it is intended to specifically detect and sequence tumor DNA circulating in patients' blood. The results are used to help guide doctors to tailor the best treatment for patients at each point of their disease. More...
26 Dec 2017
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The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.
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