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Pathology

Image: Arrhythmic Gut Microbiome Signatures Predict Risk of Type 2 Diabetes (Photo courtesy of Technical University of Munich).

Type 2 Diabetes Associated with Arrhythmic Daily Gut Microbe

Type 2 diabetes (T2D), formerly known as adult-onset diabetes, is a form of diabetes that is characterized by high blood sugar, insulin resistance, and relative lack of insulin. Common symptoms include increased thirst, frequent urination, and unexplained weight loss. More...
16 Jul 2020
Image: The Oncotype DX Genomic Prostate Score (GPS) test is a strong independent predictor of prostate cancer-specific death and disease progression (metastases) at 10 years in men with localized prostate cancer (Photo courtesy of Genomic Health).

Gene Genomic Prostate Score Test Evaluated as Prognosis Predictor

Molecular assays, including multi-gene expression assays, are increasingly used clinically to improve risk stratification for men with newly diagnosed prostate cancer (PCa). More...
13 Jul 2020
Image: RNA from all bodily organs is present in the blood and can be used to detect pregnancy complications (Photo courtesy of Illumina).

Early-Onset Preeclampsia Risk Reflected in Circulating Maternal Transcripts

Preeclampsia is a poorly understood pregnancy-associated disorder. Often marked by hypertension, preeclampsia can lead to severe complications including internal bleeding, seizures, stroke, premature birth, and death. More...
13 Jul 2020
Image: The Idylla system is a fully-automated, real-time polymerase chain reaction (PCR) based molecular testing system designed to offer results in a minimal amount of time (Photo courtesy of Biocartis).

Rapid Genomic Profiling of Colon Cancers Improves Therapy Selection

Colorectal cancer is a malignant tumor arising from the inner wall of the large intestine (colon) or rectum. Colorectal cancer is the third leading cause of cancer in both men and women in the USA. Most colorectal cancers develop from polyps. Removal of colon polyps can aid in the prevention of colorectal cancer. More...
09 Jul 2020
Image: The Bioanalyzer RNA 6000 Nano assay provides reliable and reproducible characterization of total RNA and mRNA from multiple sample types (Photo courtesy of Agilent Technologies).

RNA Sequencing as Alternative to Immunohistochemistry in Cancer Diagnostics

The conventionally used method for cancer diagnostics relies on immunohistochemical dyeing of tumor tissue sections. It allows detecting the presence and measuring the concentration of marker proteins characterizing malignant growths. The resulting microscope images indicate whether the tumor is malignant and what its molecular type is. This information is crucial for selecting the right therapy. More...
06 Jul 2020
Image: Aggregates of immune cells known as tertiary lymphoid structures (TLSs), seen here within a tumor of the soft tissues known as a rhabdomyosarcoma, are major players in the immune system’s fight against cancer (Photo courtesy of Johns Hopkins Kimmel Cancer Center).

Immune Cells Hampered Fighting Soft Tissue and Bone Sarcomas

Immunotherapies such as checkpoint inhibitors that enhance the body's natural ability to fight cancer have been only minimally successful in treating sarcomas which are rare cancers that grow in the soft tissues and bones. More...
06 Jul 2020
Image: The NF-light (Neurofilament light) ELISA kit allows fast quantification in less than three hours of neurofilament light in cerebrospinal fluid (Photo courtesy of Andreas Nilsson).

Blood Test Could Predict Multiple Sclerosis Progression

Multiple sclerosis (MS) is an immune-mediated neurodegenerative disease of the central nervous system (CNS), with a highly variable inter-individual disease course. As a result, even if using existing clinical prognostic factors, the forecasting of long-term prognosis is often unreliable and imprecise. More...
01 Jul 2020
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The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.
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