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Pathology

Image: Clostridium septicum is a gram positive, spore forming, obligate anaerobic bacterium and increases the risk of colon cancer (Photo courtesy of Alchetron).

Bacterial Blood Infections Tied to Heightened Colon Cancer Risk

Colorectal cancer occurs in the colon or the rectum and it is the third most common type of cancer in the USA. Around 90% of cases occur in people aged 50 years or older. As well as age, risk factors include a family history of colorectal cancer, some genetic syndromes, obesity, and a lack of exercise, a diet low in fruit and vegetables, and inflammatory bowel disease. More...
12 May 2020
Image: Multicancer Blood Test Aids Screen for Cancer Guide Intervention (Photo courtesy of fotoquique/Depositphotos).

Multicancer Blood Test Aids Screen for Cancer Guide Intervention

As minimally invasive screening tests, liquid biopsies could help reduce cancer-specific morbidity and mortality through earlier detection. However, there is debate on how to effectively screen large populations for cancer, including individuals who do not have symptoms or history of the disease. More...
12 May 2020
Image: Histopathological micrograph of pancreatic adenocarcinoma arising in the pancreas head region (Photo courtesy of KGH).

Biomarker Data Improves Risk Prediction for Pancreatic Cancer

Pancreatic cancer risk prediction models based on clinical factors may be refined and improved by bringing in other types of data, including germline genetic risk variant and blood-based biomarker data. More...
07 May 2020
Image: The Invitrogen Qubit 1X dsDNA HS Assay Kit (Photo courtesy of Thermo Fisher Scientific).

Targeted Next-Generation Sequencing Validated for Lysosomal Storage Disorders Diagnosis

Lysosomal storage disorders (LSDs) are a group of more than 50 inherited rare disorders characterized by the accumulation of specific undegraded metabolites in the lysosomes. This overstorage is commonly caused by a deficient or absent activity of one of the many lysosomal hydrolases or, in a few cases, by the deficit of other non-enzymatic lysosomal proteins. More...
04 May 2020
Image: The nanoString nCounter: This instrument provides a simple and cost-effective solution of direct digital quantification for multiplex analysis of up to 800 known RNA, DNA, or protein targets in one tube (Photo courtesy of the Crown Institute of Genomics).

Genetic Alterations Analyzed in Pediatric Low-Grade Glioma

Low grade gliomas are brain tumors that come from two different types of brain cells known as astrocytes and oligodendrocytes. They are classified as a grade 2 tumor making them the slowest growing type of glioma in adults. More...
28 Apr 2020
Image: Schematic Diagram of the Molecular Analysis of Clinically Defined Subsets of High-Grade Serous Ovarian Cancer (Photo courtesy of MD Anderson Cancer Center).

Molecular Differences Discovered Among Ovarian Cancer Subgroups

Ovarian cancer is a highly diverse disease with a high rate of overall mortality. High-grade serous ovarian cancer (HGSC) is the most common and aggressive type of epithelial ovarian cancer, exhibiting high levels of tumor heterogeneity and variable clinical outcomes. More...
28 Apr 2020
Image: Histological photomicrograph of a colonic biopsy showing a crypt abscess, a classic finding in ulcerative colitis (Photo courtesy of KGH).

Important Genetic Mechanism Behind Inflammatory Bowel Disease Revealed

The two main forms of Inflammatory Bowel Disease (IBD), Crohn's disease and ulcerative colitis, have an important genetic component. More than 240 genetic regions have been identified that associate with IBD, more than any other pathological condition that has been studied. More...
23 Apr 2020
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The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.
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