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Pathology

Image: A diagram shows how the microfluidics device separates cancer cells from blood. The green circles represent cancer cells (Photo courtesy of Professor Ian Papautsky, PhD).

New Microfluidics Device Detects Cancer Cells in Blood

The ability to successfully isolate cancer cells is a crucial step in enabling liquid biopsy where cancer could be detected through a simple blood draw. This would eliminate the discomfort and cost of tissue biopsies, which use needles or surgical procedures as part of cancer diagnosis. More...
12 Mar 2019
Image: A photomicrograph of a glomerulus with changes characteristic of a transplant glomerulopathy. Transplant glomerulopathy is considered a form of chronic antibody-mediated rejection (Photo courtesy of Nephron).

Blood Test Predicts Kidney Transplant Rejection

A renal transplant offers the best treatment for patients whose kidneys have failed, with around 3,000 carried out annually in the UK. Acute rejection occurs when the body's immune system begins to attack the donated organ. More...
12 Mar 2019
DIASOURCE (A Biovendor Company)
Image: Immunohistochemical stain for CD137 performed on paraffin-embedded tissue sections (cytoplasmic and membranous) using monoclonal BBK-2 clone (original magnification ×400) (Photo courtesy of Peter N. Carbone, MD and Qian-Yun Zhang, MD, PhD).

Immunohistochemical Stain Facilitates cHL Diagnosis

Remarkable efforts are underway to exploit classic Hodgkin lymphoma's (cHL) complex interplay of molecular alterations, loss of B-cell programming, and dependency of tumor microenvironment. More...
11 Mar 2019
Image: The Accuri C6 compact flow cytometer (Photo courtesy of BD Biosciences).

Cervical Microbes Potentially Tied to Infections and Lesions

Nearly all cervical cancers are causally associated with human papillomavirus (HPV). The burden of HPV-associated dysplasias in sub-Saharan Africa is influenced by human immunodeficiency virus (HIV). More...
07 Mar 2019
Image: A histopathology of the bile duct of a patient with biliary atresia: loss of bile ducts, brisk ductular reaction, and bile plugs (Photo courtesy of Hopkins GI Pathology).

Genetic Defect Linked to Pediatric Liver Disease

Biliary atresia (BA) is the most common cause of end‐stage liver disease in children and the primary indication for pediatric liver transplantation, yet underlying etiologies remain unknown. More...
04 Mar 2019
Image: A histopathology of gastric adenocarcinoma representing a signet ring cell variant identified in an endoscopic biopsy specimen (Photo courtesy of KGH).

Gastric Cancer Analysis Identifies Four Subtypes

In previous studies of gastric cancers (GCs), genomic and transcriptomic analyses have identified molecular signatures associated with phenotypes of the disease, such as patient subtypes and survival. New proteogenomic analysis of diffuse gastric cancers (GCs) in young populations identified four subtypes of the disease. More...
28 Feb 2019
Image: The Nextera DNA Library Preparation Kit (Photo courtesy of Illumina).

Gene Missense Variant Associated with Crohn's Disease

Gene-microbiome interactions are important in etiology and pathogenesis of inflammatory bowel disease, a chronic inflammatory disorder of the gastrointestinal tract consisting of Crohn’s disease and ulcerative colitis. More...
21 Feb 2019
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The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.
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