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Pathology

Image: Photomicrograph of cytomegalovirus colitis (Photo courtesy of Nephron)

Immunohistochemistry Evaluated for Tissue-Invasive Cytomegalovirus in Gastrointestinal Mucosal Biopsies

Cytomegalovirus (CMV) immunohistochemistry (IHC) is the most widely used method to diagnose CMV infection/reactivation in tissues in a pathology laboratory. More...
04 Mar 2022
Image: Strong nuclear and cytoplasmic p16 staining of a section from an HPV+ oropharynx tumor. Lymphocytes (blue arrow) and endothelial cells (black arrow) are unstained (Photo courtesy of Jonathon McHugh, MD)

TTMV-HPV DNA Biomarker Predicts Recurrence of Oropharynx Cancer

A large, multi-institutional study demonstrates that a blood test to detect circulating tumor DNA can accurately predict recurrence of HPV-driven oropharyngeal cancer following treatment. Results also indicate that the biomarker test may detect recurrent disease earlier than imaging or other standard methods of post-treatment surveillance, allowing physicians to personalize treatment more quickly for patients whose cancer returns. More...
03 Mar 2022
Image: Lipoprotein(a), or Lp(a), is a distinctive particle with two components: a lipoprotein core that resembles LDL, along with a shell that contains apolipoprotein(a), or apo(a).

Two Important Cardiovascular Disease Risk Factors Operate Independently

Determination of blood levels of the cholesterol-rich biomarker lipoprotein(a) [Lp(a)] and the coronary artery calcium (CAC) score are independently associated with risk of developing coronary artery disease and may be useful concurrently for guiding therapy approaches to prevent its occurrence . More...
02 Mar 2022
Image: Schematic diagram of the IMMray PanCan-d assay that relies on the IMMray microarray technology, where single chain fragment antibodies are printed onto a slide in a measured amount as a microarray of different antibody biomarkers (Photo courtesy of Immunovia)

Immunoassay Detects Pancreatic Cancer in People at High Risk

An immunoassay was able to detect pancreatic cancer in high-risk individuals and with high sensitivity and specificity. More...
28 Feb 2022
Image: Oxford BioDynamics Plc has announced the successful clinical validation and US launch of its Checkpoint Inhibitor Response Test (Photo courtesy of Oxford BioDynamics)

First-of-Its-Kind Clinical Blood Test Predicts Cancer Patient’s Response to ICI Immunotherapy

A first-of-its-kind clinical blood test predicts the likelihood of a cancer patient’s response to an essential, widely used class of therapeutics – Immune Checkpoint Inhibitors (ICIs) – including anti-PD-L1 and anti-PD-1 immunotherapies. More...
28 Feb 2022
Image: Histopathology of dilated cardiomyopathy of unknown etiology in a 58 year female. The histologic findings in dilated cardiomyopathy are usually nonspecific. The image shows myocyte hypertrophy with enlarged hyperchromatic nuclei, mixed with myocyte atrophy and stretching. In addition, there is focal interstitial fibrosis (Photo courtesy of Dr. Dharam Ramnani)

Tintin-Truncating Variant Associated With Late-Onset Dilated Cardiomyopathy

Late-onset dilated cardiomyopathy might represent a distinct disease subtype marked by an increased burden of genetic variants, a new study has found. The findings further suggested that genetic testing may be beneficial for older dilated cardiomyopathy patients. More...
21 Feb 2022
Image: Highly atypical cells in marrow examined for large cell transformation. Bone marrow core biopsies demonstrating (A) highly atypical cells including cells with prominent spindling of the nucleus and (B) cells with marked pleomorphism and/or multinucleation (Photo courtesy of Yale Medicine)

Histological Criteria Predicts Lymphoma Transformation in Bone Marrow Biopsies

Large cell transformation (LCT) of indolent B-cell lymphomas, such as follicular lymphoma (FL) and chronic lymphocytic leukemia (CLL), signals a worse prognosis, at which point aggressive chemotherapy is initiated. Although LCT is relatively straightforward to diagnose in lymph nodes, a marrow biopsy is often obtained first given its ease of procedure, low cost, and low morbidity. However, consensus criteria for LCT in bone marrow have not been established. More...
16 Feb 2022
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The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.
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