Pathology
First-of-Its-Kind Clinical Blood Test Predicts Cancer Patient’s Response to ICI Immunotherapy
A first-of-its-kind clinical blood test predicts the likelihood of a cancer patient’s response to an essential, widely used class of therapeutics – Immune Checkpoint Inhibitors (ICIs) – including anti-PD-L1 and anti-PD-1 immunotherapies. More...28 Feb 2022
Tintin-Truncating Variant Associated With Late-Onset Dilated Cardiomyopathy
Late-onset dilated cardiomyopathy might represent a distinct disease subtype marked by an increased burden of genetic variants, a new study has found. The findings further suggested that genetic testing may be beneficial for older dilated cardiomyopathy patients. More...21 Feb 2022
Histological Criteria Predicts Lymphoma Transformation in Bone Marrow Biopsies
Large cell transformation (LCT) of indolent B-cell lymphomas, such as follicular lymphoma (FL) and chronic lymphocytic leukemia (CLL), signals a worse prognosis, at which point aggressive chemotherapy is initiated. Although LCT is relatively straightforward to diagnose in lymph nodes, a marrow biopsy is often obtained first given its ease of procedure, low cost, and low morbidity. However, consensus criteria for LCT in bone marrow have not been established. More...16 Feb 2022
Cytosponge Biomarker Panel Prioritizes Endoscopic Barrett's Esophagus Surveillance
Endoscopic surveillance is recommended for patients with Barrett's esophagus because, although the progression risk is low, endoscopic intervention is highly effective for high-grade dysplasia and cancer. However, repeated endoscopy has associated harms and access has been limited during the COVID-19 pandemic. We aimed to evaluate the role of a non-endoscopic device (Cytosponge) coupled with laboratory biomarkers and clinical factors to prioritize endoscopy for Barrett's esophagus. More...15 Feb 2022
In Other News
Novel Urinary miRNA Biomarker for Early Detection of Colorectal Cancer
New Method Determines Optimal Number of Pathologists Needed for Correct Disease Diagnosis
Diagnostic Value of Serum CHI3L1 in Hepatocellular Carcinoma Explored
Proteomic Noninvasive Biomarkers Associated with Sport-Related Concussions
Melanoma Test Offers Reassurance of Low Risk of Cancer Spread
Immuno-CRISPR Assay Helps Diagnose Early Kidney Transplant Rejection
Long Mononucleotide Repeat Markers Validated for Microsatellite Instability Detection
Natural Killer Cell-Associated Markers Investigated in Gastric Cancer
Association Between Helicobacter pylori With Nonalcoholic Fatty Liver Disease Assessed
Novel Protein Biomarkers Identified for Prostate Cancer Aggressiveness
Near Normal Aminotransferase Levels Reported in Alcoholic Cirrhosis Patients
Biomarker FR+CTC Explored for Breast Cancer Diagnosis
Tissue Counterpart to Monoclonal B-Cell Lymphocytosis Characterized
3D Imaging Method Determines Prostate Cancer Aggressiveness
Intratumor Heterogeneity Analyzed in Neuroblastoma
Genomic Screening Can Identify Risk for Amyloid Cardiomyopathy
Cystic Pancreatic Lesion Bacteria Are Precursors to Pancreatic Cancer
Roche Introduces AI-Based Digital Pathology RUO Algorithms for Evaluation of Breast Cancer Markers
Targeted RNA-Sequencing Panel Detects Gene Fusions in Solid Tumors
Assay Developed for Patient-Specific Monitoring and Treatment for Ovarian Cancer
Specific Biomarker Investigated for Triple-Negative Breast Cancer Diagnosis
Serum MicroRNA Panel Predict P-Tau/Aβ42 in CSF in Alzheimer's Disease
AI-Based Pathology Diagnostic Tool for Gastric Cancer Achieves 100% Sensitivity in Trials
The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.