We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

LabMedica

Download Mobile App
Recent News Expo
ADLM 2025
Clinical Chem. Molecular Diagnostics Hematology Immunology Microbiology Pathology Technology Industry Focus

New Genetic Tool Analyzes Umbilical Cord Blood to Predict Future Disease

By LabMedica International staff writers
Posted on 29 Apr 2025

Children are experiencing metabolic problems at increasingly younger ages, placing them at higher risk for serious health issues later in life. There is a growing need to identify this risk from birth to enable preventative measures. Now, the umbilical cord may serve as a tool for doctors to predict which children are more likely to face long-term health problems, such as diabetes, stroke, and liver disease. DNA changes found in cord blood could provide early insights into which infants are at higher risk, paving the way for earlier and potentially life-saving interventions, according to research presented at Digestive Disease Week (DDW) 2025.

Researchers at Duke University Health System (Durham, NC, USA) utilized a novel genetic tool to analyze umbilical cord blood from 38 children who were part of the Newborn Epigenetics Study, a long-term birth cohort study. They focused on identifying changes in chemical tags—known as methyl groups—on the infants’ DNA that regulate gene activity. When these changes occur in critical areas of DNA, called imprint control regions, their effects can persist from fetal development into later life. The research team then compared the DNA changes with health data collected when the children reached ages 7 to 12. This data included body mass index, liver fat levels, alanine transaminase (ALT) — a marker of liver inflammation or damage, triglyceride levels, blood pressure, and waist-to-hip ratio.


Image: Umbilical cord blood can provide clues to preventable health issues later in life (Photo courtesy of Shutterstock)
Image: Umbilical cord blood can provide clues to preventable health issues later in life (Photo courtesy of Shutterstock)

The team identified several DNA regions where changes were linked to metabolic dysfunction later in childhood. For instance, alterations in the TNS3 gene were associated with liver fat, ALT levels, and waist-to-hip ratio, while changes in genes such as GNAS and CSMD1 were linked to blood pressure, waist-to-hip ratio, and ALT. Although the sample size was small, the researchers believe the findings are promising and warrant further exploration. A larger follow-up study is already underway. While these findings do not establish a direct cause-and-effect relationship between the genetic changes and disease, they highlight potential biological pathways that warrant further investigation.

“These epigenetic signals are laid down during embryonic development, potentially influenced by environmental factors such as nutrition or maternal health during pregnancy,” said co-author Cynthia Moylan, MD, associate professor of medicine, division of gastroenterology, at Duke University Health System. “If validated in larger studies, this could open the door to new screening tools and early interventions for at-risk children.”


Gold Member
Antipsychotic TDM Assays
Saladax Antipsychotic Assays
3-Part Differential Hematology Analyzer
Swelab Alfa Plus Sampler
New
Blood Glucose Test Strip
AutoSense Test
New
Gel Cards
DG Gel Cards

Latest Pathology News

Novel Method To Analyze Tumor Growth Rates Helps Tracks Progression Between Diagnosis and Surgery
29 Apr 2025  |   Pathology

Novel Technology Detects Key Mutations from Blood Samples in Metastatic Colorectal Cancer Patients
29 Apr 2025  |   Pathology

Self-Driving Microscope Tracks and Analyzes Misfolded Protein Aggregation in Real Time
29 Apr 2025  |   Pathology



PURITAN MEDICAL