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Recent News Expo ADLM 2026 Clinical Chem. Molecular Diagnostics Hematology Immunology Microbiology Pathology Technology Industry Focus

Immunology

Image: An immunohistochemistry of the new biomarker DNAJB9 greatly improves diagnostic sensitivity for the rare kidney disease, fibrillary glomerulonephritis (Photo courtesy of Mayo Clinic).

Potential Autoantigen Identified in Aggressive Kidney Disease

Fibrillary glomerulonephritis (FGN) is an aggressive kidney disease, and nearly half of patients become dependent on dialysis within several years of diagnosis. No unique clinical markers of FGN have been identified to help diagnose FGN, and current tests involve time-consuming analyses with light microscopy, immunofluorescence, and electron microscopy. More...
13 Nov 2017
Image: Immunostaining for immunoglobulin G4 (IgG4) in IgG4-related inflammatory aortic aneurysm; abundant IgG4-positive plasma cell infiltration (Photo courtesy of Shiga University of Medical Science).

Disease Associations Discovered with Four IgG Subclasses

Immunoglobulin G4-related disease (IgG4-RD) is a relatively newly defined disease entity that refers to a group of immune-mediated disorders that have certain histopathologic, serologic, and clinical features in common. More...
08 Nov 2017
Image: The Videssa Breast is the first blood test of its kind that detects and analyzes multiple types of tumor protein biomarkers for improved cancer detection (Photo courtesy of Provista Diagnostics).

Blood Test Can Effectively Rule Out Breast Cancer

Breast density is associated with reduced imaging resolution in the detection of breast cancer. Breast density is a radiologic phenomenon that is not discernable by palpation; it is a radiologist’s assessment. Imaging rays permeate dense breast tissue in a more opaque manner, thereby reducing image resolution. More...
07 Nov 2017
Image: The ADXBLADDER MCM5 ELISA kit for the diagnosis of bladder cancer (Photo courtesy of Arquer Diagnostics).

Noninvasive Test Detects Bladder Cancer

In Europe, bladder cancer represents the fourth most common cancer in men and the 15th most common cancer in women, with 151,000 people diagnosed with the condition in 2012. In order to make a bladder cancer diagnosis, experts currently recommend cystoscopy for all patients with hematuria, in conjunction with computed tomography (CT) urography (in selected high-risk patients) or renal and bladder ultrasound. More...
07 Nov 2017
Image: The Lumipulse G CK-MB immunoassay, an aid in the diagnosis of acute myocardial infarction, being prepared to run on a LUMIPULSE G1200 instrument (Photo courtesy of Fujirebio Europe).

CK-MB Assay Used to Diagnose Acute Myocardial Infarction

Creatine Kinase (CK) is an enzyme found in high amounts in muscle tissue due to its role in muscle contraction. CK-MB is found mainly in cardiac muscle, where it comprises 15%-40% of the total CK activity, with the remainder being CK-MM. More...
07 Nov 2017
Image: Dipstick tests for dengue (left) and Zika (right) accurately identify the presence of Zika virus protein in a sample (Photo courtesy of Massachusetts Institute of Technology).

Novel Immunochromatographic Method Rapidly Identifies Flaviviruses

The recent Zika virus (ZIKV) outbreak demonstrates that cost-effective clinical diagnostics are urgently needed to detect and distinguish viral infections to improve patient care. Unlike dengue virus (DENV), ZIKV infections during pregnancy correlate with severe birth defects, including microcephaly and neurological disorders. More...
01 Nov 2017
Image: Box‐and‐whisker plot comparisons between nonsurvivors (n=8) and survivors (n=35) by: (A) body mass index, (B) maximal inspiratory pressure, and (C) N‐terminal pro‐brain natriuretic peptide (NT‐proBNP) (Photo courtesy of Cheeran D et al, 2017, Journal of the American Heart Association).

Risk Factors Identified for Duchenne Muscular Dystrophy-Associated Cardiomyopathy

Researchers have now identified important factors associated with death, thus highlighting a high‐risk DMD population with a worse cardiovascular and overall prognosis. More...
30 Oct 2017
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The Immunology channel of LabMedica deals with diagnostic techniques and immuonassays such as ELISA, pregnancy tests, immunoblotting, immunohistochemical staining, serology, and associated hardware.
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