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Immunology

Image: Breast cancer: immunohistochemical comparison of three estrogen receptor antibodies: A through C, 1D5 and 6F11 show negativity, whereas SP1 shows positivity (Photo courtesy of Stanford University Medical Center).

Hormone Receptor Antibody Reagents Assessed for Breast Cancer

Immunohistochemical analysis of estrogen receptor (ER) and progesterone receptor (PgR) expression in breast cancer is the current standard of care and directly determines therapy. More...
08 Aug 2017
Image: The cobas e 411immunoassay analyzer (Photo courtesy of Roche Diagnostics).

Performance of Immunosuppressant Drug Assay Kits Analyzed

Cyclosporine (CsA) and tacrolimus (TAC) are immunosuppressant drugs that are often used to treat autoimmune diseases and as transplantation therapy and therefore, their concentrations need to be monitored carefully. More...
08 Aug 2017
Image: A scanning electron micrograph of a CD8+ T cell engaging a virus (Photo courtesy of Dennis Kunkel).

Genetic Variation Associated with Influenza Severity Identified

It is estimated that in the USA influenza -related deaths in recent years have ranged from 12,000 to 56,000. Factors like age, obesity, pregnancy and such chronic health conditions as asthma, chronic lung disease and heart disease are associated with an elevated risk of complications and death. More...
03 Aug 2017
Image: A new blood test has been developed to differentiate Zika virus infection from other flaviviruses (Photo courtesy of Brett Israel, University of California-Berkeley).

New Test Distinguishes Zika from Similar Viral Infections

Zika is a mosquito-borne disease and is linked to severe congenital birth defects. Assays already exist to detect Zika virus infection, but they either work only shortly after infection or are poor at differentiating Zika from other flaviviruses. More...
02 Aug 2017
Image: Immunofluorescent antibody stain showing positive Powassan virus-infected cells (Photo courtesy of Coppe Laboratories).

Powassan Virus Diagnosed in Patients with Tick-Borne Diseases

Powassan virus (POWV) lineage II, also known as deer tick virus, is an emerging tick-borne flavivirus transmitted by Ixodes scapularis ticks, which are also the primary vector for the Lyme disease pathogen Borrelia burgdorferi. More...
02 Aug 2017
Image: Immunohistochemistry for alpha-synuclein showing positive staining (brown) of an intraneural Lewy-body in the brain substantia nigra in Parkinson\'s disease (Photo courtesy of Wikimedia).

Lipid-ELISA Improves Detection of Potential PD Biomarker

Researchers have developed a novel diagnostic approach for Parkinson’s Disease (PD), which enabled assaying of total alpha-synuclein in whole blood cells (WBC), cerebrospinal fluid (CSF), and saliva. The new ELISA assay could lead to early diagnosis and improved monitoring of PD progression and patient response to therapy. More...
31 Jul 2017
Image: The BRAHMS Kryptor fully automated immunoanalyzer (Photo courtesy of Thermo Fisher Scientific).

Immunoassay Systems Compared for Trisomy Screenings

The biochemical serum markers free β-human chorionic gonadotropin (hCGβ) and pregnancy associated plasma protein A (PAPP-A) are used in screening for trisomy 21 (T21), trisomy 18 (T18), and trisomy 13 (T13) during the first trimester. More...
25 Jul 2017
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The Immunology channel of LabMedica deals with diagnostic techniques and immuonassays such as ELISA, pregnancy tests, immunoblotting, immunohistochemical staining, serology, and associated hardware.
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