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Immunology

Image: The NanoQuant infinite M200 pro reader is an easy-to-use multimode plate reader family (Photo courtesy of Neotec Scientific Instrumentation)

CCN1 Analyzed as a Biomarker for Breast Cancer Detection

Breast cancer is the most frequent malignancy in women with 1.7 million new cases and over 500,000 deaths worldwide in 2016. Early detection of cancer is believed to be crucial in reducing cancer death. Despite recent progress in liquid biopsy technologies, early blood-based detection of breast cancer is still a challenge. More...
14 Sep 2021
Image: The autoimmune signature of hyperinflammatory multisystem inflammatory syndrome in children (Photo courtesy of Cedars-Sinai Medical Center)

Biomarkers Found for COVID-19 MIS-C Condition in Children

Multisystem Inflammatory Syndrome in Children (MIS-C) manifests as a severe and uncontrolled inflammatory response with multiorgan involvement, occurring weeks after SARSCoV-2 infection. More...
13 Sep 2021
Image: Immunohistochemical staining showing IgG4-positive plasma cells (white arrows) from a girl with sclerosing mesenteritis (Photo courtesy of King Saud bin Abdulaziz University for Health Sciences)

Protein-Expression Changes Specific to Immunoglobulin G4-Related Disease Analyzed

Immunoglobulin 4 (IgG4)-related disease (IgG4-RD) is a lymphoproliferative disorder characterized by elevated serum IgG4 levels and infiltration of IgG4-positive plasma cells into the affected tissues. More...
09 Sep 2021
Image: Blood sample tube for Immunoglobulin G or IgG subclass test (Photo courtesy of Blood Tests London)

Immunoglobulin Levels Investigated in Adults with IgG Subclass Deficiency

Immunoglobulin G (IgG) subclass deficiency (IgGSD) is characterized by frequent or severe upper or lower respiratory tract infection, one or more subnormal IgG subclass level(s) unexplained by other causes, and decreased IgG response to pneumococcal polysaccharide vaccination (PPSV). More...
30 Aug 2021
Image: Histopathology of (a) Usual-type high-grade urothelial carcinoma and (b) Positive E-cadherin expression in usual-type high-grade urothelial carcinoma. (Photo courtesy of Emory University School of Medicine)

Biomarker p-120 Catenin Distinguishes Conventional Urothelial Carcinoma from Variants

Plasmacytoid urothelial carcinoma (PC-UC) is an infrequent and clinically aggressive variant of urothelial carcinoma (UC). Initially, PC-UC was identified based on morphology as a potential mimicker of malignant plasma cell and lymphoid neoplasms and is characterized by loss of E-cadherin (E-Cad)–mediated intercellular adhesion. More...
24 Aug 2021
The LIAISON XL is a fully automated chemiluminescence analyzer, performing complete sample processing as well as measurement and evaluation (Photo courtesy of DiaSorin)

Automated Assays Evaluated For High-Sensitivity Thyroglobulin Measurement

Thyroglobulin (Tg) is a tumor marker for differentiated thyroid carcinoma (DTC) originating from thyroid follicular cell and is an important tumor marker for therapy control. Over the past decade, assays for highly sensitive Tg measurement have become increasingly established. More...
12 Aug 2021
Antisynthetase Syndrome Patients with positive immunohistochemistry reaction of (A) YKL-40, (B) YKL-40 (higher magnification); (C), a specimen from a patient with antisynthetase syndrome, but without infiltrate inflammation; (D) CD68, (E) CD4, and (F) CD8 (Photo courtesy of Universidade de Sao Paulo).

Serum YKL-40 Levels Measured In Antisynthetase Syndrome Patients

Antisynthetase syndrome (ASSD) is a rare systemic autoimmune myopathy characterized by muscle, joint, and pulmonary involvement, as well as by the presence of fever, “mechanic’s hands,” and Raynaud’s phenomenon. More...
10 Aug 2021
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The Immunology channel of LabMedica deals with diagnostic techniques and immuonassays such as ELISA, pregnancy tests, immunoblotting, immunohistochemical staining, serology, and associated hardware.
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