Hematology
Clonal Hematopoiesis and Recurrent Mutations Identified in Blood Cancers
Clonal hematopoiesis of indeterminate potential (CHIP) is characterized by detectable hematopoietic-associated gene mutations in a person without evidence of hematologic malignancy. Somatic mutations at hotspots (genetic loci observed to be frequently mutated across cancer patients) often drive or contribute to cancer pathogenesis. More...16 Mar 2021
COVID-19 Induces a Hyperactive Phenotype in Circulating Platelets
Coronavirus Disease 2019 (COVID-19) is characterized by a marked pro-inflammatory response with fever, elevated inflammatory markers, and clinical and radiological features of pneumonitis being evident among affected individuals. More...15 Mar 2021
Hemoglobin Levels Measured with AI Microscope, Microfluidic Chips
A complete blood count can help ascertain the health of a patient and typically includes an estimate of the hemoglobin concentration, which can indicate several conditions, including anemia, polycythemia, and pulmonary fibrosis. More...10 Mar 2021
Blood Tests Offer Early Indicator of Severe COVID-19
For most patients, COVID-19 manifests as an upper respiratory tract infection that is self-limited. However, the progression of COVID-19 in a large subset of patients to respiratory distress, multiorgan failure, and death has resulted in an enormous global impact. More...09 Mar 2021
Rh Alloimmunization Explored in Chronically Transfused Thalassemia Patients
Chronic life-long transfusions are often required for patients with severe thalassemia to provide normal red blood cells and to suppress the patients’ own ineffective erythropoiesis. Cumulative exposure increases the risk for red cell alloimmunization and subsequent delayed hemolytic transfusion reactions (DHTRs). More...01 Mar 2021
Next Generation Sequencing Finds More Gene Mutations for Leukemia
Myeloid malignancies are characterized by uncontrolled proliferation and/or defects in differentiation of abnormal myeloid progenitor cells. Myelodysplastic syndromes (MDS) and myeloproliferative neoplasms (MPNs) are often thought to be precursors to a higher grade myeloid malignancies, namely acute myeloid leukemia (AML). More...18 Feb 2021
Biomarker Predicts Pancreatic Cancer Patients’ Response to CD40 Immunotherapy
Pancreatic ductal adenocarcinoma (PDAC) is the most common type of pancreatic cancer and currently the third leading cause of cancer deaths in the USA. Despite the fact that it only accounts for about 3% of new cancer cases, it is responsible for more than 7% of all cancer deaths, and only10% of patients survive five years with the disease. More...17 Feb 2021
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In Other News
Automated Leucocyte VCS Parameters Evaluated for Pathogenic Infections
TFP Inhibitor Levels Elevated in Bleeding Tendency Patients
RDW Levels Associated with Adverse Outcomes in COVID-19 Patients
ABO Histo-Blood Groups Influence Makeup of Gut Microbiome
Specific RUNX1 Mutations Cause Different Disease Types
Tryptophan Metabolism Is Dysregulated in Individuals with Fanconi Anemia
Coagulopathy Testing Linked to Better COVID-19 Outcomes
Preterm Infants Tolerate Restrictive Red Blood Cell Transfusion Strategy
Next Generation Sequencing Developed for Monitoring of Mixed Chimerism
Automated Hematologic Reference Intervals Defined for Newborns
Blood Type Linked to Risk of COVID-19 Infection Severity
Chronic Lymphocytic Leukemia Increases Peripheral Blood Hematopoietic Stem Cells
Next-Generation Sequencing Detects Residual Disease in Acute Lymphoblastic Leukemia
Elevated Soluble C5b9 Biomarker Found in SARS-CoV-2 Infected Children
Two Automated Hematology Analyzers Compared for Performance
Diagnostic Assays Evaluated for Vitamin B12 and Folate Deficiency
Single-Cell Analysis Elucidates Mutation Patterns in Myeloid Malignancies
Anticoagulant Adjustment Evaluated Using Different Prothrombin Time Tests
CD200 Expression Marks Leukemia Stem Cells in Human AML
Blood Cell Mutations Underlie Severe Autoinflammatory Disease
Paper Diagnostic Directly Measures Fibrinogen in Whole Blood
Newborns Getting Preoperative Blood Transfusions Have More Complications
Single-Cell Sequencing Reveals Clonal Diversity Among AML Patients
The Hematology channel at LabMedica covers the all aspect of plasma, coagulation, transfusion medicine, and blood banking, as well as related lab tools and techniques.