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Hematology

Image: Fibrinogen Test: people with low fibrinogen levels show a rapid movement of blood up the device (Photo courtesy of Monash University).

Paper Diagnostic Directly Measures Fibrinogen in Whole Blood

Fibrinogen is a protein found in blood that is needed for clotting. When a patient experiences traumatic injury, such as a serious car accident, or major surgery and childbirth complications, fibrinogen is required in their blood to prevent major hemorrhaging and death from blood loss. More...
10 Nov 2020
Image: A newborn baby’s foot with a peripheral intravenous catheter in the neonatal intensive care unit. Newborns undergoing surgery suffered worse outcomes if they had received preoperative blood transfusion (Photo courtesy of Atichayo).

Newborns Getting Preoperative Blood Transfusions Have More Complications

Blood transfusions in the neonatal patient population are common, but there are no established guidelines regarding transfusion thresholds. Little is known about postoperative outcomes in neonates who receive preoperative blood transfusions (PBTs). More...
05 Nov 2020
Image: The NovaSeq 6000 Sequencing System (Photo courtesy of Illumina).

Single-Cell Sequencing Reveals Clonal Diversity Among AML Patients

A growing body of evidence supports the role of clonal diversity in therapeutic resistance, recurrence, and poor outcomes in cancer. Clonal diversity also reflects the history of the accumulation of somatic mutations within a tumor. More...
03 Nov 2020
Image: Mutations in cell free DNA (cfDNA) or cells in the peripheral blood along with anemia or thrombocytopenia are the hallmark of myelodysplastic syndrome (MDS). The diagnosis of MDS is confirmed when mutations in hematopoietic cells are detected at relatively high levels (Photo courtesy of Genomic Testing Cooperative).

Inherited Causes of Clonal Hematopoiesis in Multiplicity of Whole Genomes

The age-related acquisition of somatic mutations that lead to clonal expansion in regenerating hematopoietic stem cell populations has recently been associated with both hematological cancer and coronary heart disease, and this phenomenon is termed clonal hematopoiesis of indeterminate potential (CHIP). More...
29 Oct 2020
Image: An Acousto Thermal Shift Assay `lab-on-a-chip` device shown next to a US quarter for size comparison. The device can diagnose sickle cell anemia (Photo courtesy of CU Boulder College of Engineering and Applied Science).

New Technology Rapidly Diagnoses Sickle Cell Disease

Sickle cell disease (SCD) is a group of blood disorders typically inherited from a person's parents. The most common type is known as sickle cell anemia (SCA). It results in an abnormality in the oxygen-carrying protein hemoglobin found in red blood cells. More...
29 Oct 2020
Image: The EUROPattern Microscope Live: Ultrafast fluorescence microscopy that automatically detects anti-neutrophil cytoplasmic antibodies (Photo courtesy of EUROIMMUN AG).

Methods for Automated Anti-Neutrophil Cytoplasmic Antibodies Compared

The detection of anti-neutrophil cytoplasmic antibodies (ANCA) by indirect immunofluorescence assays (IFA) is of diagnostic importance in vasculitis and some other inflammatory diseases. More...
21 Oct 2020
Image: Photomicrograph of histopathology of hepatocellular carcinoma, the most common form of primary liver cancer, showing end-stage cirrhosis - blue collagen (fibrosis) Mallory bodies; loss of normal liver architecture; and nuclear atypia. (Photo courtesy of Nephron).

Hematological Biomarkers Predict Prognosis in Hepatocellular Carcinoma

Hepatocellular carcinoma (HCC) is an inflammation-related cancer, where non-resolving inflammation contributes to its development and progression. Peripheral inflammatory cells have been shown to be associated with the prognosis of various types of cancer. More...
12 Oct 2020
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The Hematology channel at LabMedica covers the all aspect of plasma, coagulation, transfusion medicine, and blood banking, as well as related lab tools and techniques.
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