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Hematology

Image: Bone marrow aspirate showing mature plasma cells with eccentric nuclei and abundant basophilic cytoplasm indicative of multiple myeloma (Photo courtesy of Dr. David Israel Garrido, MD et.al.)

Personalized CtDNA Analysis Detects Minimal Residual Disease

Multiple myeloma (MM), is a type of bone marrow cancer. It is called multiple myeloma as the cancer often affects several areas of the body, such as the spine, skull, pelvis and ribs. Minimal residual disease (MRD) is the name given to small numbers of leukemic cells that remain in the person during treatment, or after treatment when the patient is in remission. More...
08 Jun 2021
Image: The AcuStar Hemostasis Testing System (Photo courtesy of Werfen)

PF4 Immunoassays Investigated in Vaccine-Induced Thrombotic Thrombocytopenia

Post-vaccination embolic and thrombotic events, also termed vaccine-induced prothrombotic immune thrombocytopenia (VIPIT) or vaccine-induced immune thrombotic thrombocytopenia (VITT) are rare types of blood clotting events that were initially observed in a very small number of people who had previously received the COVID-19 vaccine. More...
07 Jun 2021
Image: The Mindray BC-6800 hematology analyzer (Photo courtesy of Shenzhen Mindray Bio-Medical Electronics)

Platelet Indices Analyzed for Tuberculosis and Diabetes Mellitus Co-Morbidity

Studies have demonstrated that some diseases accelerate Tuberculosis (TB) occurrence and development. Type 2 diabetes mellitus (DM) has been verified as one of the threatening risk factors for TB, and patients have three times the risk of developing TB compared to non-diabetic patients due to pathogenic mechanisms and metabolic factors. More...
03 Jun 2021
Image: Appearance of a common form of typical migraine visual aura (Photo courtesy of Poojitha Mamindla, PharmD)

Hemostatic Profile Associated with Migraine with Aura

Nearly 15% of the population in the USA experiences migraine. One subtype of migraine that is not well understood is migraine with aura (MA). Individuals who experience MA often see flashing lights, blind spots, or jagged lines in their visual field prior to onset of their migraine headaches. More...
31 May 2021
Image: The Star Evolution coagulation analyzer (Photo courtesy of Diagnostica Stago)

Coagulation and Fibrinolysis Assessed in Splenic Injury Patients

The most frequently injured solid organ following blunt abdominal trauma is the spleen. Splenectomy was a standard surgical procedure for splenic injury until the mid‐20th century. However, thrombotic and infectious complications following splenectomy were demonstrated by many studies. More...
19 May 2021
Image: Bone marrow smear from a patient with refractory anemia (MDS) with ring sideroblasts. Classic appearance of ring sideroblasts shows iron deposition in a `necklace` around the nucleus using Perls stain (Photo courtesy of University of Pavia)

Hematological and Molecular Parameters Defined for CCUS and MDS

Patients with clonal cytopenia of undetermined significance (CCUS) have low blood counts and a normal bone marrow examination, but more advanced genetic testing shows the presence of a genetic mutation that is likely causing the low counts. More...
11 May 2021
Image: Histology showing pathological and immunopathological findings from a spinal cord lesion from a 52-year-old woman who died from active neuromyelitis optica associated with a longitudinally extensive spinal cord lesion extending from C3 to T8 (Photo courtesy of CHU de Strasbourg)

African-American MS Patients Experience More Rapid B-Cell Repopulation

Multiple sclerosis (MS) is a potentially disabling disease of the brain and spinal cord (central nervous system). In MS, the immune system attacks the protective sheath (myelin) that covers nerve fibers and causes communication problems between the brain and the rest of the body. More...
06 May 2021
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The Hematology channel at LabMedica covers the all aspect of plasma, coagulation, transfusion medicine, and blood banking, as well as related lab tools and techniques.