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Molecular Diagnostics

Image: The ABI 3730xl capillary DNA sequencer (Photo courtesy of Thermo Fisher Scientific).

Genetic Mutation Linked to New Form of Diabetes

Finding the genetic cause of rare familial diabetes (monogenic diabetes) provides new biological insights into human pancreas development and function, as well as potentially novel therapeutic targets with important treatment implications. More...
02 Nov 2017
Image: The Agilent 2100 Bioanalyzer is a microfluidics-based platform for sizing, quantification and quality control of DNA, RNA, proteins and cells (Photo courtesy of CORELAB).

Viral Marker Predicts Flu Severity in Infected Patients

Influenza A viruses are the causative agents of annual epidemics, sporadic zoonotic outbreaks and occasionally pandemics. Worldwide, acute respiratory infections caused by influenza A viruses continue to be one of the main causes of acute illness and death. More...
01 Nov 2017
Image: Histopathology of a retinoma showing abundant fleurettes and sparse cells with eosinophilic cytoplasm. Retinomas share the same genetic origin as retinoblastomas (Photo courtesy of Helen Dimaras, PhD).

Genetic Testing Recommended for Children at Risk for Retinoblastoma

Retinoblastoma is a cancer that starts in the retina at the very back of the eye. It can also spread to other parts of the body, including the brain and bones. There are approximately 350 new cases diagnosed each year in the USA. More...
31 Oct 2017
Image: A micrograph of prostatic adenocarcinoma (conventional, acinar type) with perineural invasion. Prostate biopsy, H&E stain (Photo courtesy of Wikimedia).

Biomarker Revealed Helps Guide Cancer Treatment Decisions

In two back-to-back studies, researchers demonstrate how a testosterone-related genetic abnormality can help monitor and predict individual patient responses to specific prostate cancer (PC) therapies. More...
30 Oct 2017
Image: The system uses a commercial smartphone to acquire and interpret real-time images of an enzymatic amplification reaction that takes place in a silicon microfluidic chip that generates green fluorescence and displays a visual read-out of the test. The system is composed of an unmodified smartphone and a portable 3-dimensional-printed cradle that supports the optical and electrical components, and interfaces with the rear-facing camera of the smartphone (Photo courtesy of the Micro & Nanotechnology Laboratory, University of Illinois at Urbana-Champaign).

Potential Uses for Smartphone-Based Diagnostic Tool Described

Two recent papers described potential applications for a smartphone-based instrument that can evaluate biological samples with the accuracy of clinical laboratory analyzers but at a fraction of the cost. More...
30 Oct 2017
Image: Sensitivity of the loop-mediated isothermal amplification (LAMP) assay for the detection of Clonorchis sinensis eggs in feces experimentally spiked with a known number of eggs in ten-fold serial dilutions from 10,000 eggs (lane 1) to one egg (lane 5) (Photo courtesy of Seoul National University Medical Research Center).

LAMP Assay Detects Clonorchiasis in Human Samples

Clonorchiasis is prevalent in the Far East, and a major health problem in endemic areas. Infected persons may experience, if not treated, serious complications such as bile stone formation, pyogenic cholangitis, and even cholangiocarcinoma. More...
26 Oct 2017
Image: Trypanosoma cruzi amastigotes in heart tissue from a patient with Chagas disease (Photo courtesy of the CDC).

Next-Generation Immunoassay Developed for Chagas Diseases

Chagas disease, caused by the protozoan Trypanosoma cruzi, is a major health and economic problem in Latin America for which no vaccine or appropriate drugs for large-scale public health interventions are yet available. More...
26 Oct 2017
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.
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