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Molecular Diagnostics

Image: Islet of Langerhans from the pancreas of a patient with chronic type 1 diabetes of 19 years duration. A single lobe of the pancreas was found to contain islets rich in residual beta cells (alpha cells in red; beta cells in green) (Photo courtesy of Diapedia).

Genetic Scores Stratify Risk of Developing Type 1 Diabetes

Approximately 0.3% of newborns will develop autoimmunity to pancreatic beta cells in childhood and subsequently develop type 1 diabetes before adulthood. Primary prevention of type 1 diabetes will require early intervention in genetically at-risk infants. More...
15 May 2018
Image: The C1000 Touch thermal cycler (Photo courtesy of Bio-Rad).

Assays Using ddPCR Quantify DNA Fragments

Optimized droplet digital polymerase chain reaction (ddPCR) assays have been developed that quantify short and long DNA fragments. These assays have been used to analyze plasma cell-free (cfDNA) fragment size distribution in human blood. More...
14 May 2018
Image: An Epstein-Barr virus budding in a B cell (Photo courtesy of Kenyon College).

EBV Protein Implicated in Autoimmune Diseases

Epstein-Barr Virus (EBV) infection is common and more than 90% of people in the USA become infected by age 20. While resulting in mild disease or no symptoms in children, EBV causes mononucleosis in adolescents and young adults, with symptoms that include fever and extreme fatigue. More...
09 May 2018
Image: The HiSeq 4000 Systems leverage innovative patterned flow cell technology to provide rapid, high-performance sequencing (Photo courtesy of Illumina).

Molecular Tests Equivalent to Bone Marrow Analysis for MM

Multiple myeloma (MM) is a hematologic malignancy characterized by a bone marrow infiltration of clonal plasma cells with heterogeneous involvement in many areas of the bone marrow. More...
09 May 2018
Image: A histopathology micrograph of anaplastic thyroid carcinoma (Photo courtesy of The Clayman Thyroid Cancer Center).

Thyroid Cancer Genetics Study Finds New Mutations

Anaplastic thyroid cancer (ATC) is a form of thyroid cancer, which has a very poor prognosis due to its aggressive behavior and resistance to cancer treatments. Its anaplastic cells have poor differentiation, including dedifferentiation. More...
08 May 2018
Image: A collection of SHERLOCK paper test strips: Unused paper strips (Left); Paper tests displaying a negative SHERLOCK readout (Middle); Paper tests displaying a positive SHERLOCK readout (Right) (Photo courtesy of Broad Institute of MIT and Harvard).

Diagnostic SHERLOCK Optimized for Rapid Viral Detection

New technique enables SHERLOCK to detect a virus directly in bodily fluids, eliminating a step that required laboratory equipment and expanding the platform's potential to quickly and cheaply track pathogens such as Zika during an outbreak. More...
08 May 2018
Image: The new streamlined approach discovered for diagnosing and treating bowel cancer (Photo courtesy of University of Adelaide).

Streamlined Approach Discovered for Treating Bowel Cancer

More than 4,000 Australians die from bowel cancer each year, and more than 17,000 new cases of this cancer will be diagnosed in 2018. Scientists are working to understand the genetic drivers of bowel cancer, with a special interest in those cancers which are the hardest to treat, and which have the poorest prognosis. More...
02 May 2018
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.
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