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Molecular Diagnostics

Image: Histopathology of a retinoma showing abundant fleurettes and sparse cells with eosinophilic cytoplasm. Retinomas share the same genetic origin as retinoblastomas (Photo courtesy of Helen Dimaras, PhD).

Genetic Testing Recommended for Children at Risk for Retinoblastoma

Retinoblastoma is a cancer that starts in the retina at the very back of the eye. It can also spread to other parts of the body, including the brain and bones. There are approximately 350 new cases diagnosed each year in the USA. More...
31 Oct 2017
Image: A micrograph of prostatic adenocarcinoma (conventional, acinar type) with perineural invasion. Prostate biopsy, H&E stain (Photo courtesy of Wikimedia).

Biomarker Revealed Helps Guide Cancer Treatment Decisions

In two back-to-back studies, researchers demonstrate how a testosterone-related genetic abnormality can help monitor and predict individual patient responses to specific prostate cancer (PC) therapies. More...
30 Oct 2017
Image: The system uses a commercial smartphone to acquire and interpret real-time images of an enzymatic amplification reaction that takes place in a silicon microfluidic chip that generates green fluorescence and displays a visual read-out of the test. The system is composed of an unmodified smartphone and a portable 3-dimensional-printed cradle that supports the optical and electrical components, and interfaces with the rear-facing camera of the smartphone (Photo courtesy of the Micro & Nanotechnology Laboratory, University of Illinois at Urbana-Champaign).

Potential Uses for Smartphone-Based Diagnostic Tool Described

Two recent papers described potential applications for a smartphone-based instrument that can evaluate biological samples with the accuracy of clinical laboratory analyzers but at a fraction of the cost. More...
30 Oct 2017
Image: Sensitivity of the loop-mediated isothermal amplification (LAMP) assay for the detection of Clonorchis sinensis eggs in feces experimentally spiked with a known number of eggs in ten-fold serial dilutions from 10,000 eggs (lane 1) to one egg (lane 5) (Photo courtesy of Seoul National University Medical Research Center).

LAMP Assay Detects Clonorchiasis in Human Samples

Clonorchiasis is prevalent in the Far East, and a major health problem in endemic areas. Infected persons may experience, if not treated, serious complications such as bile stone formation, pyogenic cholangitis, and even cholangiocarcinoma. More...
26 Oct 2017
Image: Trypanosoma cruzi amastigotes in heart tissue from a patient with Chagas disease (Photo courtesy of the CDC).

Next-Generation Immunoassay Developed for Chagas Diseases

Chagas disease, caused by the protozoan Trypanosoma cruzi, is a major health and economic problem in Latin America for which no vaccine or appropriate drugs for large-scale public health interventions are yet available. More...
26 Oct 2017
Image: A pipette machine allows the scientists in the Karius laboratory to process blood samples within one day (Photo courtesy of Hamilton).

Novel Blood Test Identifies Pathogens in Suspected Sepsis

A diagnostic test that can accurately identify the cause of sepsis is important to determine the most effective and appropriate antimicrobial therapy; however, a causative pathogen is not always identified in a large percentage of sepsis cases. More...
26 Oct 2017
Image: Whole genome genotyping arrays are an important tool for discovering variants that contribute to human disease (Photo courtesy of Megan Smolenyak, MBA).

New Genetic Risk Factors Identified for Peanut Allergy

Peanut allergy develops in early life and is rarely outgrown. Roughly 1% of Canadian adults and between 2% and 3% of Canadian children are affected, and the symptoms can be severe and even life threatening. More...
25 Oct 2017
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.
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