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Molecular Diagnostics

Image: A histopathology of extensive hepatocyte necrosis seen here in a case of paracetamol overdose. The hepatocytes at the right are dead, and those at the left are dying. This pattern can be seen with a variety of hepatotoxins (Photo courtesy of the University of Utah Medical School).

Test Detects Overdose Patients at Risk of Liver Damage

Paracetamol is a safe analgesic drug when taken at therapeutic doses; however, in overdose, paracetamol is hepatotoxic and is the most common cause of acute liver failure in the USA and Europe. More...
28 Nov 2017
Image: Diagram of DiviTum sTK1 assay: BrdUTP is subsequently incorporated into a solid-phase DNA-strand. Incorporated BrdU is detected using an anti-BrdU monoclonal antibody conjugated to the signal generating enzyme alkaline phosphatase. The level of BrdU incorporated over time is proportional to the level of thymidine kinase activity in the sample (Photo courtesy of Biovica).

Blood Test Reduces Interim for Evaluating Cancer Treatment

Although prognosis and treatment of metastatic breast cancer (MBC) have improved over the last years, there is still an unmet clinical need for more precise prognostic and treatment monitoring tools. More...
27 Nov 2017
Image: A recent study suggests clues taken from small molecules in saliva may be able to help diagnose and predict the duration of concussions in children (Photo courtesy of Penn State University College of Medicine).

MicroRNA Panel Detects Concussion Symptoms in Children

A panel of microRNAs has been shown to be a potent biomarker for the detection of prolonged concussion symptoms in children. More...
27 Nov 2017
Image: A CPK model of the oxytocin molecule (Photo courtesy of Wikimedia Commons).

Microfluidic Platform Devised for Determination of Autism Biomarker

A team of Polish scientists has devised a unique electrochemical microfluidic platform for determination of the autism biomarker oxytocin. More...
27 Nov 2017
Image: Pregnancy-associated plasma protein A and free β-human chorionic gonadotropin assays (Photo courtesy of Roche).

Prenatal Reflex DNA Screens for Three Trisomies

At present, women are offered screening for these three chromosome disorders at 10-14 weeks of pregnancy. The test combines an ultrasound scan and a blood test, and if it shows that a woman is at an increased risk of having an affected pregnancy. More...
22 Nov 2017
Image: A photomicrograph of a renal biopsy specimen suggesting acute tubular necrosis is the patchy or diffuse denudation of the renal tubular cells with loss of brush border (blue arrow) (Photo courtesy of the University of Alberta).

Autoimmune Disease Discovered Causes Kidney Failure

An insidious new autoimmune disease that causes kidney failure has been discovered. The condition causes a build-up of waste products in the blood and makes it difficult for kidneys to maintain adequate balance of fluid in the body. More...
15 Nov 2017
Image: An immunohistochemistry of PharmDX 22c3 staining of non-small-cell lung carcinoma (Photo courtesy of Agilent).

Assay Identifies Patients Benefiting from Cancer Immunotherapies

Programmed cell death ligand 1 (PD-L1) has been detected in up to 50% of all human cancers, and has become a major focus of therapeutic and biomarker studies. More...
14 Nov 2017
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.