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Molecular Diagnostics

Image: A recent study suggests clues taken from small molecules in saliva may be able to help diagnose and predict the duration of concussions in children (Photo courtesy of Penn State University College of Medicine).

MicroRNA Panel Detects Concussion Symptoms in Children

A panel of microRNAs has been shown to be a potent biomarker for the detection of prolonged concussion symptoms in children. More...
27 Nov 2017
Image: A CPK model of the oxytocin molecule (Photo courtesy of Wikimedia Commons).

Microfluidic Platform Devised for Determination of Autism Biomarker

A team of Polish scientists has devised a unique electrochemical microfluidic platform for determination of the autism biomarker oxytocin. More...
27 Nov 2017
Image: Pregnancy-associated plasma protein A and free β-human chorionic gonadotropin assays (Photo courtesy of Roche).

Prenatal Reflex DNA Screens for Three Trisomies

At present, women are offered screening for these three chromosome disorders at 10-14 weeks of pregnancy. The test combines an ultrasound scan and a blood test, and if it shows that a woman is at an increased risk of having an affected pregnancy. More...
22 Nov 2017
Image: A photomicrograph of a renal biopsy specimen suggesting acute tubular necrosis is the patchy or diffuse denudation of the renal tubular cells with loss of brush border (blue arrow) (Photo courtesy of the University of Alberta).

Autoimmune Disease Discovered Causes Kidney Failure

An insidious new autoimmune disease that causes kidney failure has been discovered. The condition causes a build-up of waste products in the blood and makes it difficult for kidneys to maintain adequate balance of fluid in the body. More...
15 Nov 2017
Image: An immunohistochemistry of PharmDX 22c3 staining of non-small-cell lung carcinoma (Photo courtesy of Agilent).

Assay Identifies Patients Benefiting from Cancer Immunotherapies

Programmed cell death ligand 1 (PD-L1) has been detected in up to 50% of all human cancers, and has become a major focus of therapeutic and biomarker studies. More...
14 Nov 2017
Image: The Hitachi ABI 3130XL capillary electrophoresis genetic analyzer system (Photo courtesy of Cal-L enterprises).

Assay May Boost Treatment of Non-Hodgkin Lymphoma

Diffuse large B-cell lymphoma (DLBCL) is an aggressive cancer and the most frequently diagnosed non-Hodgkin lymphoma worldwide. Recent advancements indicate that both the prognosis and choice of treatment of DLBCL may depend on identifying its molecular subtype. More...
14 Nov 2017
Image: A scanning electron micrograph (SEM) of breast cancer cells (Photo courtesy of SPL).

Blood Test Detects Resistance to BRCA-Targeting Drugs

Resistance to platinum-based chemotherapy or PARP inhibition in germline BRCA1 or BRCA2 mutation carriers may occur through somatic reversion mutations or intragenic deletions that restore BRCA1 or BRCA2 function. More...
14 Nov 2017
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