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Molecular Diagnostics

Image: The Accela liquid chromatography system (Photo courtesy of Thermo Fisher Scientific).

Lipid Species Offer Insights into Metabolic Health

Heart disease is the number one killer in the USA, and high triglyceride levels in the blood are cited as just one of several risk factors. Millions of lipid panels, blood tests that look at cholesterol levels as well as triglycerides, are performed in clinics each year. More...
11 Jul 2018
Image: A bronchial tube, cells stained red and blue are part of the bronchial epithelium, or lining. This demonstrates the existence among these cells of a rare cell type (stained blue-green), believed to be a tuft cell. The scientists have discovered a new type of lung cancer with origins in these cells, which overexpress a gene-regulating protein called POU2F3, a potential target for therapy (Photo courtesy of Cold Spring Harbor Laboratory).

New Genre of Small-Cell Lung Cancer Discovered

Small cell lung cancer (SCLC) is widely considered to be a tumor of pulmonary neuroendocrine cells; however, a variant form of this disease has been described that lacks neuroendocrine features. More...
10 Jul 2018
Image: A histopathology of papillary non–muscle-invasive bladder cancer (Photo courtesy of American Urological Association).

Simple Test Could Reduce Treatment of Bladder Cancer

Bladder cancer is relatively common and imposes the highest per patient cost on the healthcare system of the USA than the management of any other cancer type. Most bladder cancers are early-stage tumors known as papillary non-muscle-invasive bladder cancer (NMIBC). More...
09 Jul 2018
Image: An artist\'s depiction of the operating principle of single-molecule sequencing (Photo courtesy of Osaka University).

Current-Tunneling Measurements Analyze Single DNA Molecules

A team of Japanese genomics researchers has devised a method for cancer diagnosis, which is based on the analysis of single molecules of DNA without the need for chemical modification or amplification. More...
09 Jul 2018
Image: A Western blot analysis of vCJD prions obtained after amplification by protein misfolding cyclic amplification (PMCA) of cerebrospinal fluid (CSF) from two patients with vCJD (MM and MV) and three control patients and a crude reference brain homogenate from a vCJD patient (Photo courtesy of Etablissement Français du Sang).

Variant CJD Diagnosed by Protein Misfolding Amplification

Variant Creutzfeldt-Jakob disease (vCJD) is a neurodegenerative infectious disease caused by transmission of a cattle prion disease (bovine spongiform encephalopathy) to humans. Most vCJD cases have occurred in the United Kingdom, where an estimated 1 in 2,000 persons is potentially asymptomatically infected. More...
06 Jul 2018
Image: The HiSeq 2000 sequencing platform (Photo courtesy of Illumina).

Recurrent Rearrangements Identified in Soft Tissue Tumors

A new genomic and transcriptomic analysis of rare, soft tissue tumors that develop in infants has detected recurrent specific gene rearrangements that may render them responsive to targeted treatment. More...
06 Jul 2018
Image: Neuromyelitis optica (NMO) is an autoimmune disease and a potentially fatal disease in which the immune system attacks cells in the optic nerve and spinal cord. Aquaporin-4–immunoglobulin G (AQP4-IgG) is the specific biomarker for NMO spectrum disorders and most accurately diagnosed using a cell-based blood test (Photo courtesy of Mayo Clinic Laboratories).

DNA Code Unraveled for Rare Neurologic Disease

Neuromyelitis optica (NMO) is a potentially fatal disease in which the immune system attacks cells in the optic nerve and spinal cord, leaving some patients blind and/or paralyzed. More...
04 Jul 2018
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.
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