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Molecular Diagnostics

Image: The MinION is the only portable real-time device for DNA and RNA sequencing (Photo courtesy of Oxford Nanopore Technologies).

Pneumonia Diagnosed by Nanopore Sequencing of Sputum

Pathogen identification in patients with community-acquired pneumonia primarily relies on culture-based techniques. Sequencing-based approaches for pathogen identification are being applied to pneumonia patients. More...
04 Oct 2018
Image: The NEBNext ultra directional RNA library prep kit (Photo courtesy of New England Biolabs).

Nanopore Sequencing Enables Outbreak Field Surveillance

Outbreaks of fever of unknown origin start with nonspecific symptoms and case definition is only slowly developed and adapted, therefore, identifying the causative agent is crucial to ensure suitable treatment and control measures. More...
03 Oct 2018
Image: The AmplideX PCR/CE C9orf72 assay kit (Photo courtesy of Asuragen).

Dementia Assay Gets Favorable Evaluation

An assay to detect the most common genetic mutation associated with amyotropic lateral sclerosis (ALS) and frontotemporal dementia (FTD) has been shown to have significant advantages over a laboratory-developed test in an evaluation. More...
27 Sep 2018
Image: Bone marrow aspirate smear from a patient with myelodysplastic syndromes, unclassifiable (MDS-U) (pancytopenia and -7 cytogenetic abnormality). Occasional late mitotic figures in erythroid elements are present, but no significant erythroid or myeloid dysplasia exists (Photo courtesy of Dr. Robert P. Hasserjian, MD).

Disease Progression Apprised by Post-Treatment Mutation Sequencing

Allogeneic hematopoietic stem-cell transplantation is the only curative treatment for patients with myelodysplastic syndrome (MDS). The molecular predictors of disease progression after transplantation are unclear. More...
26 Sep 2018
Image: A blood film from a patient with acute myeloid leukemia (Photo courtesy of the University of Toronto).

DNA Test Predicts Risk of Leukemia Relapse

Acute myeloid leukemia (AML) is the most common type of leukemia in adults, comprising about one quarter of all cases. The disease stems from an overproduction of immature blood cells in the bone marrow, which over time outgrow normal blood cells. It's a type of cancer, which starts suddenly and progresses quickly, requiring urgent treatment. More...
25 Sep 2018
Image: The matrix-assisted laser desorption ionization–time of flight mass spectrometer (Photo courtesy of Bruker Daltonics).

MALDI-TOF MS Used to Identify Pythiosis

Pythiosis is a life-threatening infectious disease caused by the oomycete Pythium insidiosum. The disease has been increasingly reported worldwide and most patients with pythiosis undergo surgical removal of an infected organ. More...
25 Sep 2018
Image: A micrograph of non-alcoholic fatty liver disease, demonstrating marked steatosis (fatty liver appears white) (Photo courtesy of Wikimedia Commons).

Determining Fibrosis Stage in Non-Alcoholic Fatty Liver Disease

Measurement of a specific biomarker identifies advanced fibrosis in patients with non-alcoholic fatty liver disease. More...
24 Sep 2018
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.
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