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Molecular Diagnostics

Image: Blood test for organ transplant monitoring using DNA sequencing (Photo courtesy of National Heart, Lung and Blood Institute).

Blood Test Improves Detection of Severe Transplant Rejection

Lung transplant recipients have the shortest survival rates among patients who get solid organ transplantation of any kind as only about half live past five years. More...
04 Feb 2019
Image: Genesig Advanced kits can be used for human pathogen screening with the genesig q16, a qPCR instrument (Photo courtesy of Primerdesign).

Diagnostic Methods for Infectious Uveitis Investigated

Uveitis is the inflammation of the uvea, the pigmented layer that lies between the inner retina and the outer fibrous layer composed of the sclera and cornea. Uveitis can have many causes, including eye injury and inflammatory diseases. More...
04 Feb 2019
Image: Tumor Mutation Burden by Targeted Next Generation Sequencing Predicts Benefit to Immune Checkpoint Inhibitors for Cancer (Photo courtesy of Rutgers Cancer Institute).

Tumor Mutational Load Predicts Survival Post-Immunotherapy

A survey of thousands of advanced cancers suggests a way to identify those most likely to respond to groundbreaking therapies that unleash an immune response against tumors, but the results highlight how difficult it will be to translate such an approach into a reliable clinical test. More...
31 Jan 2019
Image: Trypanosoma cruzi in thin blood smears stained with Giemsa (Photo courtesy of Centers of Diseases Control and Prevention).

DNA Extraction Technique Improved for Chagas Diagnosis

Chagas disease, caused by the protozoan parasite Trypanosoma cruzi, is endemic in many parts of the Americas, where six to seven million people are infected. In the acute phase of the infection, serology may still be negative but positive for parasite by microscopic examination or by culture in specialized medium. More...
28 Jan 2019

Padlock Probe Assay Detects and Subtypes Seasonal Influenza

Influenza remains a constant threat worldwide, and it is estimated that it affects 5% to 15% of the global population each season, with an associated three to five million severe cases and up to 500,000 deaths. More...
24 Jan 2019
Image: The Affymetrix Genechip 3000 microarray scanner and autoloader fluidics station 450 (Photo courtesy of New-life Scientific).

Molecular Prognostic Biomarker Found for CNS Lymphoma

Primary central nervous system lymphoma (PCNSL), a rare subgroup of diffuse large B-cell lymphoma (DLBCL) arising in the central nervous system (CNS), is an aggressive malignant variant of nodal non-Hodgkin lymphoma (NHL). PCNSLs account for 3% of all primary CNS tumors and 1% of NHLs in adults. More...
24 Jan 2019
Image: The CFX384 real-time PCR detection system (Photo courtesy of Bio-Rad Laboratories).

Gene-Based Risk Scores Predicts Alcoholic Cirrhosis

Alcoholic chronic liver disease, with a prevalence of around 12% in the European and North-American populations, is characterized by a broad spectrum of conditions ranging from simple steatosis to alcoholic steatohepatitis, cirrhosis, and hepatocellular carcinoma. More...
23 Jan 2019
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.
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