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Molecular Diagnostics

Image: The GloMax Discover multimode microplate reader (Photo courtesy of Promega).

Aggressive Meningioma Linked to Transcription Factor Activity

Meningioma, a cancer of the cerebral and spinal meninges, is the most common primary CNS tumor in the USA. Meningioma is the most common primary intracranial tumor, but the molecular drivers of aggressive meningioma are incompletely understood. More...
12 Apr 2018
Image: The Ion Personal Genome Machine (PGM) System combines semiconductor sequencing technology with natural biochemistry to directly translate chemical information into digital data (Photo courtesy of Thermo Fisher Scientific).

Gut Microbiome Analysis Predicts Hospitalizations in Cirrhosis

Cirrhosis is a leading cause of mortality and healthcare expenditure due to hospitalizations worldwide. Bacterial products such as endotoxin play a key role in the development of a proinflammatory milieu and disease progression in cirrhosis. More...
11 Apr 2018
Image: UW-OncoPlex is a diagnostic tool that uses genetic sequencing to look for mutations that cause cancer (Photo courtesy of University of Washington).

Genomic Test Detects Lynch Syndrome in Colorectal Cancer

Lynch syndrome (LS) affects approximately 3% of all patients with colorectal cancer (CRC), making it the most common hereditary syndrome that predisposes individuals to develop CRC. Universal tumor screening for LS in CRC is recommended and involves up to six sequential tests. More...
11 Apr 2018
Image: The SureSelect All Exon kits are the most widely used target enrichment solution for exome sequencing (Photo courtesy of Agilent Technologies).

Potential Genetic Link Identified in SIDS

Sudden infant death syndrome (SIDS) is the unexpected death of a seemingly healthy infant. It is the leading cause of post-neonatal infant death in high-income countries and accounts for 2,400 deaths per year in the USA alone and around 300 in the UK. More...
10 Apr 2018
Image: A senior medical laboratory scientist conducting the IsolateFibromyalgia blood test (Photo courtesy of IquityLabs).

Novel RNA Blood Test Launched for Fibromyalgia

It is estimated that about five million Americans suffer from fibromyalgia, a poorly understood disorder characterized by deep tissue pain, fatigue, headaches, mood swings and insomnia. It often takes years for a patient to be diagnosed with fibromyalgia and some doctors still refuse to recognize it as a disease. More...
10 Apr 2018
Image: A histological micrograph showing endometrium with abundant plasma cells, which are diagnostic for chronic endometritis and scattered neutrophils (Photo courtesy of Nephron).

Molecular Diagnostic Tool Developed for Chronic Endometritis

Chronic endometritis is a persistent inflammation of the endometrial mucosa caused by bacterial pathogens. Although chronic endometritis can be asymptomatic, it is found in up to 40% of infertile patients and is responsible for repeated implantation failure and recurrent miscarriage. More...
04 Apr 2018
Image: A graphic comparison of a healthy joint and osteoarthritis (Photo courtesy of European Union Cordis).

New Osteoarthritis Genes Discovered

Almost nine million people in the UK suffer from osteoarthritis, a degenerative joint disease in which a person's joints become damaged, stop moving freely and become painful. Osteoarthritis is the most prevalent musculoskeletal disease and a leading cause of disability worldwide. More...
04 Apr 2018
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.