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Molecular Diagnostics

Image: On the left side of the diagram, the ABL gene from Chromosome 9 and the BCR gene from Chromosome 22 are combined together to make the ‘Philadelphia chromosome’. This chromosome has a small part at the top and a longer part of the bottom. The bottom part is labelled as a fusion gene, which is BCR and ABL combined (Photo courtesy of Macmillan Cancer Support).

Digital PCR Test Monitors CML Therapy Response

Chronic myeloid leukemia, or CML, is characterized by the "Philadelphia chromosome," a translocation of chromosomes 9 and 22 that results in the breakpoint cluster region protein- Abelson murine leukemia viral oncogene homolog 1(BCR-ABL) gene fusion. More...
28 Dec 2017
Image: Genetic testing for detecting high-risk prostate cancer (Photo courtesy of Dr. David Samadi/Oncotype).

Genetic Test Recommended for Inherited Prostate Cancer

To date, there have been few recommendations to guide physicians about when to offer men genetic consultation for prostate cancer risk. A subset of prostate cancers, about 10%-15% of all prostate cancer are inherited and that at least some of the genes that confer the inherited risk are known and testable. More...
26 Dec 2017
Image: A histopathology of Lewy body inclusion (arrow) in a pigmented neuron of the substantia nigra located in the mid-brain (Photo courtesy of the Cleveland Clinic).

Genetic Profile Identified for Dementia with Lewy Bodies

Dementia with Lewy bodies has a unique genetic profile, distinct from those of Alzheimer's disease or Parkinson's disease, according to the first large-scale genetic study of this common type of dementia. More...
25 Dec 2017
Image: An artist\'s representation of a methylated DNA molecule. The two white spheres represent methyl groups bound to two cytosine nucleotide molecules within the DNA sequence (Photo courtesy of Wikimedia Commons).

DNA Methylation Pattern Predicts Remission in Rare Juvenile Leukemia

A team of pediatric cancer researchers has shown that determination of genomic DNA methylation patterns is predictive of outcome in cases of the rare childhood cancer juvenile myelomonocytic leukemia. More...
25 Dec 2017
Image: Researchers have developed a blood sample detection method for MS (Photo courtesy of the University of Huddersfield).

Researchers Develop Metabolomics Approach for Diagnosing MS

A team of British researchers has developed a metabolomics approach for diagnosing multiple sclerosis (MS) by testing blood samples. More...
25 Dec 2017
Image: Bone marrow biopsy of a patient with multiple myeloma, showing diffuse infiltration by neoplastic plasma cells, which can be recognized by the eccentric nucleus and perinuclear halo (Photo courtesy of Dr. Michael G. Bayerl).

Multiple Myeloma Survival Associated with Enzyme Levels

Multiple myeloma (MM) is the second most common blood cancer in the USA and 30% to 50% of multiple myeloma patients have extra copies of the gene that encodes the enzyme Adenosine Deaminase, RNA Specific (ADAR1). More...
21 Dec 2017
Image: This is a malignant melanoma, the most severe form of skin cancer. Melanomas, which arise from dysplastic nevi tend to be asymmetrical, with poorly defined borders and often with varied coloration (Photo courtesy of Skin Cancer Foundation).

Phenocopies Found in Melanoma-Prone Families

Melanoma, but no other cancers, is more common in the non-carriers in these families compared to the normal population. The phenomenon whereby non-carriers of a specific mutation copy the phenotype (in this case melanoma) from their mutation-carrying relatives is known as phenocopy. More...
19 Dec 2017
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.
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