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Molecular Diagnostics

Image: The Agilent 2100 bioanalyzer is a distinctive analysis tool capable of handling cells, proteins and nucleic acids on a single platform (Photo courtesy of Agilent Technologies).

Next-Gen Sequencing of CSF Diagnoses Neurobrucellosis

Brucellosis is the most common zoonotic infection in the world with more than 500,000 new cases are reported annually worldwide. It is a multisystem infection, with variable clinical presentations and brucellosis with nervous system involvement is known as Neurobrucellosis (NB). More...
21 Feb 2018
Image: The FLUOstar Omega multi-mode microplate reader with six detection modes (Photo courtesy of BMG Labtech).

Molecular Test Adapted for Parkinson’s and DLB

Parkinson’s disease (PD), multiple system atrophy (MSA), dementia with Lewy bodies (DLB) (or Lewy body dementia) are called α-synucleinopathies due to the abnormal accumulation of aggregates of a protein called α-synuclein (αSyn) in the brain. More...
20 Feb 2018
Image: The HiSeq X whole genome sequencing system (Photo courtesy of Illumina).

Genomic Sequencing Augments Diagnosis of Lymphoid Cancer

Lymphoid cancers include diffuse large B-cell lymphomas (DLBCL), follicular lymphoma (FL), and chronic lymphocytic leukemia (CLL). In recent years, several sequencing-based assays have been developed, but their clinical applicability and utility for patients with specific mutations still needs to be verified. More...
19 Feb 2018
Image: The Infinium methylation EPIC arrays for epigenome-wide association studies (Photo courtesy of Illumina).

Epigenetic Signatures Show Promise for Diagnosing Neurodevelopmental Disorders

Genome-wide DNA methylation signatures have been discovered for several neurodevelopmental Mendelian disorders, which clinically could complement existing molecular tests. More...
15 Feb 2018
Image: A histopathology of esophageal squamous cell carcinoma with keratin pearl formation (Photo courtesy of Dr. Dharam Ramnani, MD).

Esophageal Cancer GWAS Leads to Risk Variants

Genome-wide association studies have identified common variants associated with risk of esophageal squamous cell carcinoma; however, these common variants cannot explain all heritability of esophageal cancer. More...
15 Feb 2018
Image: A photograph of the quantitative reverse transcriptase polymerase chain reaction (qRT-PCR) thermoplastic chip (Photo courtesy of Fraunhofer USA).

Molecular Test Device Developed for RNA Viral Detection

A microfluidic, continuous-flow, quantitative reverse transcriptase polymerase chain reaction (qRT-PCR) system to detect viral RNA targets has been developed and its creator have been working to reduce manufacturing costs and identify potential partners for commercialization. More...
14 Feb 2018
Image: Human papilloma virus (HPV) encased in biofilms inside tonsil crypts (pictured) may explain why the roughly 5% of HPV-infected people who develop cancer of the mouth or throat are not protected by their immune systems. Tonsil crypts with HPV are shown in green; epithelial and biofilm layers are shown in red (Photo courtesy of Dr. Katherine Rieth, MD).

HPV Found Hidden on Surface of Tonsils

Human papilloma virus (HPV), the culprit behind cervical cancer and some forms of head and neck cancer may hide in small pockets on the surface of tonsils in people not known to carry the virus. More...
14 Feb 2018
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.
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