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Molecular Diagnostics

Image: A three-dimensional (3D) computer-generated image of a group of Gram-positive, Streptococcus pneumoniae bacteria that cause invasive pneumococcal disease. The artistic recreation was based upon scanning electron microscopic (SEM) imagery (Photo courtesy of Dan Higgins/US Centers of Disease Control and Prevention).

Nasopharyngeal Pneumococcal Density Associated with Invasive Lung Disease

Streptococcus pneumoniae (pneumococcus) is one of the most important bacterial causes of pneumonia among children and adults worldwide. Nasopharyngeal pneumococcal colonization is common in young children and represents a critical initial step in the progression to invasive disease. More...
30 Oct 2019
Image: Blood tests can sample circulating DNA cast off by solid tumors, providing information about the tumor and its likely response to treatment without the need for an invasive tumor biopsy (Photo courtesy of Rachel June Wong).

Post-Treatment Colon Cancer Recurrence Identified by ctDNA Detection

By analyzing circulating tumor DNA (ctDNA) samples after treatment, it may be possible to identify stage III colon cancer patients who are at increased risk of relapse and disease progression. More...
30 Oct 2019
Image: A micrograph showing amyloid-beta (brown) in senile plaques of the cerebral cortex (upper left of image) and cerebral blood vessels (right of image) with immunostaining (Photo courtesy of Wikimedia Commons).

Degree of Amyloid-Beta Misfolding Is Predictor of Alzheimer’s Disease Risk

Measurement of misfolded Abeta (amyloid-beta) protein in blood plasma was shown to be a strong, specific risk prediction marker for clinical Alzheimer’s disease even many years before clinical diagnosis. More...
28 Oct 2019
Image: In this photomicrograph, the spiral-shaped bacteria that cause Lyme disease, Borrelia burgdorferi, have been illuminated using red and green fluorescent antibodies (Photo courtesy of the National Institute of Allergy and Infectious Diseases).

Rapid Immunoassay Shows Potential for Lyme Disease Diagnosis

A three-antigen-based immunoassay for diagnosis of Lyme disease has the potential to be developed for point-of-care use. More...
28 Oct 2019
Image: The PHOENIX system is for rapid automated identification and antimicrobial susceptibility testing of clinically relevant microorganisms (Photo courtesy of Becton, Dickinson and Company).

Methods Explored for Gram-Negative Non-Fermentative Bacteria ID

The non-fermentative Gram-negative bacteria are widely distributed in the environment and have become increasingly common isolates in the clinical laboratory. Being ubiquitous in nature, they are often disregarded as contaminants. More...
26 Oct 2019
Image: TruSeq DNA PCR-Free Kits: all-inclusive whole-genome sequencing (WGS) library preparation that provides accurate and comprehensive coverage of complex genomes (Photo courtesy of Illumina).

Trial Finds High Analytical Performance in Whole-Genome Sequencing

Genetic diseases are a leading cause of infant mortality particularly among infants admitted to neonatal, pediatric, and cardiovascular intensive care units (ICUs). Disease progression can be extremely rapid in infants, necessitating early etiologic diagnosis in order to inform interventions that can lessen suffering, morbidity, and mortality. More...
26 Oct 2019
Image: A and B, Mucinous adenocarcinoma of colon and indeterminate PMS2 immunohistochemistry staining. C and D, Poorly differentiated carcinoma of colon and indeterminate MLH1 staining. E and F, Endometrial carcinoma and focal MSH6 staining (Photo courtesy of University of Texas Southwestern Medical Center).

Lynch Syndrome Screening by IHC Leads to Mutation Studies

Lynch syndrome or hereditary nonpolyposis colorectal cancer is an autosomal dominant genetic condition that is associated with a high risk of colon cancer, as well as other cancers including endometrial cancer, ovary, stomach, small intestine, hepatobiliary tract, upper urinary tract, brain, and skin. More...
24 Oct 2019
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.