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Molecular Diagnostics

Image: The MinION is the only portable real-time device for DNA and RNA sequencing (Photo courtesy of Oxford Nanopore).

Sequencing Shows Promise for Diagnosing Prosthetic Joint Infections

A method is being developed for diagnosing infections associated with prosthetic joint implants that promises to provide results in a matter of hours as opposed to a week or more. More...
07 May 2019
Image: Neurofilaments (red) in cultured rat brain cells (Photo courtesy of Wikimedia Commons).

Neurofilament Light Considered as NIV Biomarker for Alzheimer's Disease

Results presented in a recently published paper suggested that plasma neurofilament light protein may serve as a noninvasive biomarker to monitor neurodegeneration in Alzheimer disease (AD). More...
06 May 2019
Image: A visualization of morulae in the cytoplasm of a granulocyte during examination of blood smears is highly suggestive of a diagnosis of Human Granulocytic Anaplasmosis (Photo courtesy of the US Centers for Disease Control and Prevention).

Diagnostic Methods Compared for Human Granulocytic Anaplasmosis

Human granulocytic anaplasmosis (HGA) is a tick-borne intracellular bacterial infection caused by Anaplasma phagocytophilum. The disease is present in North America, Europe, and northern Asia, areas with Ixodes ricinus ticks, the primary vector for transmission to humans. More...
02 May 2019
Image: The blood test by Natera detects breast cancer relapses (Photo courtesy of the University of Leicester).

Personalized Detection of ctDNA Antedates Breast Cancer

Breast cancer is one of the most commonly diagnosed cancers worldwide and the second leading cause of cancer-related deaths in women. The current standard of care for women with primary (non-metastatic) breast cancer is surgery, often followed with adjuvant therapy to eliminate microscopic minimal residual disease (MRD). More...
01 May 2019
Image: The ABI 7900HT Fast Real-Time PCR System (Photo courtesy of Thermo Fisher Scientific).

Novel Genes and Pathways Discovered in Celiac Disease

Celiac disease (CD) is a chronic systemic autoimmune disease that occurs globally in genetically predisposed individuals in response to ingestion of gluten-containing grains. While the pathognomonic damage occurs in the small intestine, clinical manifestations are varied and include both intestinal and extra-intestinal symptoms. More...
01 May 2019
Image: Blood film of a patient with acute myelogenous leukemia defined by presence of more than 90% myeloblasts in blood and/or bone marrow (Photo courtesy of Pathpedia).

Protein Atlas Accelerates Personalized Medicine in Leukemia Patients

Acute myelogenous leukemia is associated with risk factors that are largely unknown and with a heterogeneous response to treatment. Only about one in four people diagnosed with acute myelogenous leukemia (AML) survive five years after the initial diagnosis. More...
30 Apr 2019
Image: A histopathology of oral cancer: tumor islands can be seen infiltrating the connective tissues deep to the overlying oral epithelium. This carcinoma is moderately differentiated with a non-cohesive invasive pattern (Photo courtesy of University of Sheffield).

Biomarkers of Oral Cancer Discovered

Epigenetics, the non-genetic influences on gene expression, is a powerful mechanism capable of altering gene expression in cancer cells without changes to the DNA sequence, and can cause tumor progression. More...
30 Apr 2019
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.