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Molecular Diagnostics

Image: A blood smear of a patient with monoclonal B-cell lymphocytosis. The two atypical lymphocytes are mature with a small rim of basophilic cytoplasm and clumped or cracked chromatin (Photo courtesy of Elizabeth Courville, MD).

Circulating Plasma DNA Potentially Identifies Incipient Tumors

Early cancer diagnosis might improve survival rates. As circulating tumor DNA (ctDNA) carries cancer-specific modifications, it has great potential as a noninvasive biomarker for detection of incipient tumors. More...
06 Mar 2019
Image: Test strips of IMMY Cryptococcal Antigen Lateral Flow Assay kit (LFA) (Photo courtesy of the Institute for Medical Research, Kuala Lumpur, Malaysia).

Lateral Flow RPA Assay Developed for Cryptococcus in CSF

The most common presentations of cryptococcosis are meningitis and meningoencephalitis. Cryptococcal meningitis (CM) is a subacute meningoencephalitis and the most common cause of adult meningitis with very high mortality rates as well as vision and hearing loss in survivors. More...
06 Mar 2019
Image: The Affymetrix GeneChip Human Genome U133 Plus 2.0 array (Photo courtesy of Thermo Fisher Scientific).

Novel Test Measures Pain Biomarkers in Blood

A test that objectively measures pain biomarkers in blood has been developed. The test could help physicians better treat patients with precision medicine, and help stem the tide of the opioid crisis. More...
05 Mar 2019
Image: A histopathology of the bile duct of a patient with biliary atresia: loss of bile ducts, brisk ductular reaction, and bile plugs (Photo courtesy of Hopkins GI Pathology).

Genetic Defect Linked to Pediatric Liver Disease

Biliary atresia (BA) is the most common cause of end‐stage liver disease in children and the primary indication for pediatric liver transplantation, yet underlying etiologies remain unknown. More...
04 Mar 2019
Image: The T8 Isothermal Diagnostics Instrument provides quantitative and qualitative results for molecular diagnostic isothermal assay applications (Photo courtesy of Axxin).

Buruli Ulcer Pathogen Detected by Isothermal RPA Assay

Buruli ulcer (BU) is a neglected tropical disease caused by Mycobacterium ulcerans. The pathogenesis of BU is linked to the production of a polyketide toxin known as mycolactone, which is cytotoxic and has immunomodulatory properties and presents as nodules, plaques, ulcers and edema. More...
28 Feb 2019
Image: A histopathology of gastric adenocarcinoma representing a signet ring cell variant identified in an endoscopic biopsy specimen (Photo courtesy of KGH).

Gastric Cancer Analysis Identifies Four Subtypes

In previous studies of gastric cancers (GCs), genomic and transcriptomic analyses have identified molecular signatures associated with phenotypes of the disease, such as patient subtypes and survival. New proteogenomic analysis of diffuse gastric cancers (GCs) in young populations identified four subtypes of the disease. More...
28 Feb 2019
Image: A fundus photo showing intermediate age-related macular degeneration (Photo courtesy of National Eye Institute).

Genes Associated with Age-Related Macular Degeneration Identified

Age-Related Macular Degeneration (AMD) is a complex disease influenced by yet-to-be-understood mix of genetic and behavioral factors. Smoking increases the risk of developing the disease, while eating leafy greens and fish reduces it. More...
26 Feb 2019
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