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Molecular Diagnostics

Image: A histopathology of castration-resistant prostate cancer (Photo courtesy of Andrew J. Armstrong, MD, ScM).

Genomic Data Affects Prognosis of Advanced Prostate Cancer

Heterogeneity in the genomic landscape of metastatic prostate cancer has become apparent through several comprehensive profiling efforts, but little is known about the impact of this heterogeneity on clinical outcome. More...
22 May 2019
Image: The Affymetrix Genechip 7G scanner analyzes next-generation higher-density arrays (Photo courtesy of Thermo Fisher Scientific).

Assay Stratifies Esophageal Cancer Patients for Treatment

The incidence of esophageal adenocarcinoma (OAC) in the Western world has risen six-fold in the last 40 years with the highest incidence occurring in the UK and there were about 9,200 cases of the disease reported in the UK in 2015. It accounts for 3% of cancer cases in the UK each year. More...
22 May 2019
Image: A micrograph of a high-grade serous ovarian carcinoma (Photo courtesy of Wikimedia Commons).

Protein Panel Accurately Differentiates Forms of Ovarian Tumors

A panel of eight proteins was found that distinguishes between the milder endometrioid (EC) and more deadly high-grade serous (HGSC) forms of ovarian cancer with 99.2% accuracy. More...
20 May 2019
Image: A micrograph of urothelial carcinoma of the urinary bladder (Photo courtesy of Baylor College of Medicine).

Clinical Trial Highlights Poor Prognosis for Bladder Cancer Patients

Analysis of the IMvigor 210 clinical trials involving patients with platinum-refractory or cisplatin-ineligible urothelial carcinoma (the most common type of bladder cancer) who were treated with the PD-L1 inhibitor atezolizumab identified a resistance signature as an immune biomarker that may aid in development of personalized treatment of the disease. More...
20 May 2019
Image: (A) Low magnification view of cancer nodule with the central tumor bulk consisting predominantly of invasive cribriform Gleason pattern four. (B) Low magnification view of the same cancer nodule with an outer rim of accentuated syntaphilin (SNPH) staining. The invasive front is defined as the external rim of each cancer nodule abutting the adjacent stroma as outlined in this image as the zone between the dotted and solid lines. Arrows denote accentuated SNPH staining at the tumor-stromal interface (Photo courtesy of the American Journal of Pathology).

Prostate Cancer Severity Indicated by Location and Concentration of Syntaphilin

A biomarker has been identified that may enable doctors to predict which patients with early indications of prostate cancer will be likely to develop the much more serious invasive and metastatic form of the disease. More...
20 May 2019

Clinical Validation Bolsters Liquid Biopsy Evidence Base

Non–small-cell lung cancer (NSCLC) accounts for more than 85% of lung cancer – the majority of patients who present have advanced-stage disease and are treated with systemic therapies. More...
15 May 2019
Image: The RealTime HBV is an in vitro polymerase chain reaction (PCR) assay for the quantitation of Hepatitis B Virus (HBV) DNA in human plasma or serum from HBV-infected individuals (Photo courtesy of Abbott Molecular).

Serum HBV RNA Quantification Monitors Chronic Hepatitis B Infection

Chronic hepatitis B viral infection is a global health problem, especially in the Asian-Pacific region. Approximately 1.2 million people in the USA and 350 million people worldwide have Hepatitis B. and about 650,000 people die annually from HBV infection related liver failure, liver cirrhosis and liver cancer. More...
15 May 2019
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