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Molecular Diagnostics

Image: Droplet digital PCR measures tumor load by non-invasive means. The technique takes advantage of the cell-free DNA circulating in blood, which is found in higher concentration in cancer patients (Photo courtesy of Christof Winter, MD, PhD).

Liquid Biopsy Potential Tested with ddPCR Technology

Droplet digital polymerase chain reaction (ddPCR) technology has been used to investigate the benefits of tracking drug-resistance mutations in the circulating DNA (ctDNA) of patients with hormone receptor-positive (HR+) metastatic breast cancer. More...
10 Apr 2019
Image: A photomicrograph of a pleural fluid cytopathology specimen showing mesothelioma (Photo courtesy of Nephron).

Malignant Pleural Mesothelioma Personalized by ctDNA Profiling

Malignant pleural mesothelioma (MPM) is an aggressive tumor associated with exposure to asbestos and is rising in incidence worldwide. More...
09 Apr 2019
Image: The UltraClean PCR cleanup kit (Photo courtesy of MO BIO Laboratories).

Fecal Microbes Used to Diagnose Liver Cirrhosis

Nonalcoholic fatty liver disease (NAFLD) is the most prevalent cause of chronic liver disease worldwide, and yet remains largely underdiagnosed even in individuals with advanced stage of the disease. More...
09 Apr 2019

Genomic Analysis Used to Diagnose Neurodevelopmental and Congenital Anomalies

A recent paper described the use of genomic DNA methylation analysis to facilitate the molecular diagnosis of unresolved clinical cases of neurodevelopmental and congenital anomalies (ND/CAs) and highlighted the potential value of epigenomic testing in the routine clinical assessment of these disorders. More...
08 Apr 2019
Image: A bone marrow smear from a case of acute erythroid leukemia showing a multinucleated erythroblast with megaloblastoid nuclear chromatin (Photo courtesy of Wikimedia Commons).

Genomic Alterations and Expression Profiles Diagnose AEL

A recent paper pinpointed the genomic alterations that define the subgroups that comprise acute erythroid leukemia. More...
08 Apr 2019
Image: The QX200 droplet digital PCR system (Photo courtesy of Bio-Rad).

Digital PCR Assay Diagnoses Paucibacillary Leprosy

Leprosy, or Hansen’s disease, is a chronic bacterial disease caused by Mycobacterium leprae. Although it is curable and early treatment averts most disabilities, it remains an important global health concern. More...
04 Apr 2019
Image: A scanning electron micrograph (SEM) of lung cancer cells (Photo courtesy of Cancer Research UK).

Immune Relationship to Lung Tumor Evolution Characterized

Non-small-cell lung carcinoma (NSCLC) is any type of epithelial lung cancer other than small cell lung carcinoma (SCLC). NSCLC accounts for about 85% of all lung cancers. As a class, NSCLCs are relatively insensitive to chemotherapy, compared to small cell carcinoma. More...
04 Apr 2019
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.