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Molecular Diagnostics

Protocol summary of Vibrio cholerae DNA harvest from specimens preserved on filter paper cards (Photo courtesy of Wellcome Trust Sanger Institute).

Cholera Diagnosed from Dried Spotted Filter Paper

 Cholera outbreaks can rapidly induce high death tolls by overwhelming the capacity of health facilities, especially in remote areas or areas of civil unrest. Global estimates for cholera annually approximate four million cases worldwide with 95,000 deaths. More...
20 Jun 2019
A histopathology of pancreatic ductal adenocarcinoma, a gland-forming cancer. In this example, the adenocarcinoma has wrapped around a nerve (center of the image) (Photo courtesy of JHM).

Novel Methylated DNA Markers Assay Detects Cancer

 An estimated 56,770 people will be diagnosed with pancreatic cancer in the U.S. in 2019, and more than 45,750 will die from the disease. Pancreatic cancer is the third leading cause of cancer-related deaths in the U.S. and is expected to become the second leading cause by 2020. More...
20 Jun 2019
Representative histologic features of the small intestine. In the normal duodenal biopsy (A), the villi are elongated and the crypts relatively short. This is in contrast to the small intestinal tissue affected by celiac disease (B), which demonstrates marked villus blunting and crypt hyperplasia. (Photo courtesy of Tracy R. Ediger MD, and Ivor D. Hill, MD ChB).

Biomarker Found for Celiac Patients on Gluten-Free Diet

 Celiac disease is a complex condition, routinely treated by means of a strict gluten-free diet (GFD). One of the diagnostic challenges of this disease is that patients need to be consuming gluten so that a correct diagnosis by means of endoscopy can be made. More...
19 Jun 2019
A new study validated the use of tumor markers to select chemotherapy drugs for patients with metastatic pancreatic cancer (Photo courtesy of SPL).

Study Results Validate Use of Tumor Markers to Treat Metastatic Cancer

 Promising results obtained in a recently conducted pilot study demonstrated the feasibility of using molecular tumor markers as the basis for selecting the chemotherapeutic agents to use in patients with metastatic pancreatic cancer. More...
17 Jun 2019
In this photomicrograph, the brown areas were stained for a biomarker in tissue from a patient who developed pancreatic cancer from a cyst (Photo courtesy of Dr. Koushik Das, Washington University).

Immunodiagnostic Test Predicts Progression of Pancreatic Cyst to Cancer

 By using an immunodiagnostic test to detect the Das-1 antibody biomarker in fluid from pancreatic cysts, researchers were able to identify those cysts that were likely to become cancerous with 95% accuracy. More...
17 Jun 2019
Image: The NimbleGen MS 200 CGH LOH microarray detection scanner (Photo courtesy of Roche).

Kidney Transplant Rejection Linked to New Mismatch Locus

Approximately 20% of the kidney waiting list in the USA consists of candidates whose allografts have failed. Acute rejection is one of the strongest predictors of decreased allograft survival. More...
13 Jun 2019
Image: The SLAN-96 real-time polymerase chain reaction (PCR) instrument (Photo courtesy of QuanDx/Zeesan Biotech).

Unexpected Prevalence of High-Risk HPV Types Demonstrated

Low- and middle-income countries have high incidences of cervical cancer linked to human papillomavirus (HPV), and without resources for cancer screenings these countries bear 85% of all cervical cancer cases. More...
13 Jun 2019
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