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Molecular Diagnostics

Image: A histopathological image of cerebral glioblastoma (Photo courtesy of Wikimedia Commons).

Potential Biomarkers Found in Glioblastoma Small Extracellular Vesicles

Tumor small extracellular vesicles (sEVs), which are accessible in biofluids such as blood, contain valuable biomarkers for glioblastoma (GBM) patient diagnosis and follow-up. More...
26 Aug 2019
Image: Follicular helper T-cells (cells with green surface markers) interact closely with B-cells (cells with orange surface markers) to facilitate the proliferation of B- cells and the production of high affinity antibodies. The interaction site is shown in yellow, DNA in blue (Photo courtesy of Joyce Hu, La Jolla Institute for Allergy and Immunology).

Specialized White Blood Cells Prove Biomarkers for Diabetes Progression

Researchers have found that a specialized class of circulating white blood cells (CXCR5−PD-1hi Tph cells) are associated with progression for autoantibody positivity to clinical type I diabetes and have the potential to serve as biomarkers to monitor progression of this disease. More...
26 Aug 2019
Image: Researchers used metallic ink to screen-print an antenna and sensor onto a stretchable sticker designed to adhere to skin and track pulse and other health indicators, and transmit these readings to a receiver on a person\'s clothing (Photo courtesy of Bao Lab, Stanford University).

Study Supports Body Area Sensory Networks for Diagnostic Monitoring

The first steps have been taken on the path leading to development of a body area sensor network, which is a collection of networked sensors that can be used to remotely monitor human physiological signals. More...
26 Aug 2019
Image: A pair of genes that influence risk for Alzheimer’s disease, MS4A4A and TREM2, affect immune cells in the brain. They influence Alzheimer’s risk by altering levels of TREM2, a protein (shown stained in red) that is believed to help microglia cells clear excessive amounts of the Alzheimer’s proteins amyloid and tau from the brain. The MS4A4A protein is shown stained in green (Photo courtesy of Fabia Filipello and Dennis Oakley, Washington University School of Medicine).

Brain Biomarkers Predict Alzheimer's Disease Risk and Progression

A cluster of genes has been identified that modulates the activity of TREM2 (Triggering receptor expressed on myeloid cells 2), a protein biomarker for risk and progression of Alzheimer’s disease (AD). More...
26 Aug 2019
Image: A newborn’s blood applied to a Guthrie Card for testing for various diseases including cytomegalovirus (Photo courtesy of NHS).

Congenital Cytomegalovirus Infection Diagnosed Via Dried Blood Spots

Cytomegalovirus is the leading cause of congenital infection (cCMV) affecting up to 0.8% of newborns in high-income countries and is the most common cause of non-genetic deafness in childhood. A wide range of diseases diagnosed either at birth or in childhood, has been correlated to cCMV infection. More...
21 Aug 2019
Image: The NextSeq 500 next-generation sequencer (Photo courtesy of Illumina).

Combination of Gene Mutations Linked to Endometrial Cancer

The endometrium is the dynamic inner layer of the uterus, composed of stroma and epithelial cells that undergo monthly proliferation, differentiation, and shedding throughout the menstrual cycle in reproductive age women. More...
21 Aug 2019
Image: A biopsy of small bowel showing celiac disease manifested by blunting of villi, crypt hypertrophy, and lymphocyte infiltration of crypts (Photo courtesy of Wikimedia Commons).

Interleukin-2 Suggested as Basis for Celiac Disease Diagnostic Test

A study designed to link changes in cytokine release following ingestion of gluten by individuals suffering from celiac disease found that interleukin-2 (IL-2) was the earliest and most prominent cytokine. More...
19 Aug 2019
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