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Molecular Diagnostics

Image: The Archer FusionPlex Sarcoma Kit: A targeted sequencing assay to simultaneously detect and identify fusions of 26 genes associated with soft tissue cancers (Photo courtesy of Illumina).

Targeted Sequencing Approach for Sarcoma Gene Fusions Validated

Sarcomas are rare cancers that grow in a patient's connective tissue, such as bones, muscles, tendons, nerves, and fat. Symptoms may not be apparent, since the only signs of sarcomas are lumps on a person's skin. More...
12 Sep 2018
Image: A blood film from a patient with Chronic Lymphocytic Leukemia (CLL); a large lymphocyte (arrow) has a notched nucleus and demonstrates the variable appearance of some of the lymphocytes in CLL (Photo courtesy of Peter Maslak).

New mRNA Cancer Drivers Revealed in Chronic Lymphocytic Leukemia

New evidence has emerged showing that the inactivation or alteration of cancer suppressor genes can take place even if DNA itself remains unaltered. A known molecular mechanism for cancer development and spread is the inactivation of tumor suppressor genes, which encode various tools the body uses to keep its cells from turning cancerous. More...
11 Sep 2018
Image: A micrograph of prostate adenocarcinoma, acinar type, the most common type of prostate cancer (Photo courtesy of Wikimedia Commons).

Elevated Gene Expression Correlates with Prostate Cancer Severity

Elevated expression of the gene ANO7 has been shown to correlate with the severity and possible outcome of prostate cancer (PrCa). More...
10 Sep 2018
Image: Whole-exome sequencing provides an underlying diagnosis in an efficient, cost-effective manner and incorporates analysis of newly characterized genes (Photo courtesy of Ambry Genetics).

Breast and Ovarian Cancers Associated with Predisposition Genes

Since the discovery of BRCA1 and BRCA2, multiple high- and moderate-penetrance genes have been reported as risk factors for hereditary breast cancer, ovarian cancer, or both. More...
06 Sep 2018
Image: The HiSeq 4000 Systems provide a multi-application solution for production-scale genomic laboratories (Photo courtesy of Illumina).

Unexplained Illness Puts Pathogen Discovery to Test

High-throughput sequencing can provide insights into epidemiology and medicine through comprehensive surveys of viral genetic sequences in environmental and clinical samples. More...
05 Sep 2018
Image: Bone marrow aspirate from a patient with diffuse large B cell lymphoma (Photo courtesy of Peter Maslak).

Blood Test Predicts Lymphoma Therapy Success

A blood test can predict which patients with a type of cancer called diffuse large B cell lymphoma are likely to respond positively to initial therapy and which are likely to need more aggressive treatment. More...
04 Sep 2018
Image: Diagram of the Seq-Well low-cost platform for single-cell RNA sequencing (Photo courtesy of Shalek Lab).

Analysis of Nasal Polyps Suggests Mechanisms of Inflammation

Allergic inflammation can develop from persistent activation of type 2 immunity in the upper airway, resulting in chronic rhinosinusitis, which ranges in severity from rhinitis to severe nasal polyps. More...
04 Sep 2018
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