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Molecular Diagnostics

Image: MicroRNA miR-122 secondary structure and sequence conservation (Photo courtesy of Wikimedia Commons)

Identification of a MicroRNA Biomarker Linked to a Childhood Liver Disease

 A study of infants and young children suffering from intestinal failure-associated liver disease found that levels of the microRNA biomarker miR-122 decreased following successful fish oil treatment. More...
03 Mar 2020
Image: The ClearCell FX1 novel platform for detect circulating tumor DNA from blood samples (Photo courtesy of Explorea s.r.o.).

Heterogeneous Populations of Melanoma Circulating Tumor Cells Detected

 Circulating tumor cells (CTCs) can be assessed through a minimally invasive blood sample with potential utility as a predictive, prognostic and pharmacodynamic biomarker. The large heterogeneity of melanoma CTCs has hindered their detection and clinical application. More...
02 Mar 2020
Image: Photomicrograph of a pancreatic islet, showing insulin-producing beta cells (Photo courtesy of Wikimedia Commons)

Researchers Identify Genes Linked to the Development of Monogenic Diabetes

 By studying a well controlled group of young Lithuanian diabetes patients, researchers were able to identify genes linked to the development of the rare monogenic form of diabetes. More...
02 Mar 2020
Image: MACS Technology is a fast and gentle method for the isolation of viable and functionally active cells by magnetic labeling (Photo courtesy of University of Konstanz).

Fetal Cell-Based NIPT Demonstrated by Droplet Digital PCR

 Noninvasive testing techniques are often used for fetal diagnosis of genetic abnormalities, but are limited by certain characteristics, including non-informative results. Thus, novel methods of noninvasive definitive diagnosis of fetal genetic abnormalities are needed. More...
27 Feb 2020
Image: The ID NOW Influenza A & B 2 assay delivers molecular flu results in 13 minutes or less on the unique ID NOW platform; making it significantly faster than other molecular methods and more accurate than conventional rapid tests (Photo courtesy of Abbott Laboratories).

Point-Of-Care Molecular Tests Compared for Pediatric Influenza

 Respiratory infection by influenza (Flu) is capable of causing severe illness resulting in hospitalization and death in young children and the elderly. Early diagnosis of influenza virus is critical for patient management, infection control, and reduction of health care costs. More...
27 Feb 2020
Image: Illumina microarrays are a robust system that allow investigators to find variants in simple nucleotide polymorphisms (SNPs). The microarrays are subsequently scanned in the iScan system (Photo courtesy of LABSERGEN LANGEBIO).

Genetic Risk Factors Found in Gestational Diabetes

 Gestational diabetes mellitus (GDM) is a common pregnancy complication affecting 6%–15% of pregnancies globally. Although the condition resolves after delivery in most cases, women with a history of GDM have a more than sevenfold increased risk of developing type 2 diabetes (T2D) compared with women with a normoglycemic pregnancy. More...
26 Feb 2020
Image: Intermediate magnification micrograph of a low malignant potential (LMP) mucinous ovarian tumor (Photo courtesy of Wikimedia Commons)

Combining IL-6 Measurement with a Standard Biomarker Panel Improves Diagnosis of Ovarian Cancer

 Addition of the inflammatory biomarker IL-6 (interleukin-6) to a standard panel of tumor markers was found to enchance immunodiagnosis of ovarian cancer. More...
26 Feb 2020
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.