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Molecular Diagnostics

Image: The BioPhotometer 6131 spectrophotometer/fluorometer (Photo courtesy of Eppendorf).

PCR Kit Developed for Detection of Q-fever Pathogen

Coxiella burnetii is an obligate intracellular bacterium that causes Q fever in animals and humans. The infection results from inhalation of a spore-like small-cell variant, and from contact with the milk, urine, feces, vaginal mucus or semen of infected animals. More...
17 Oct 2019
Image: A histopathology of high-grade invasive ductal carcinoma of the breast (not otherwise specified, grade 3). This is an example of a triple-negative breast cancer, basal-like carcinoma (Photo courtesy of Lee Moffitt Cancer Center).

Triple-Negative Breast Cancer Classified from Whole-Genome Sequencing

A diagnosis of triple negative breast cancer means that the three most common types of receptors known to fuel most breast cancer growth–estrogen, progesterone and the HER-2/neu gene are not present in the cancer tumor. More...
16 Oct 2019
DIASOURCE (A Biovendor Company)
Image: Scanning electron photomicrograph (SEM) of breast cancer cells. Unselected, high-risk multigene testing for all patients with breast cancer is extremely cost-effective (Photo courtesy of Marie Thibault).

Multigene Testing for Breast Cancer Patients Proves Cost-Effective

Health systems in the UK and USA could cost-effectively screen all women with breast cancer for risky germline changes in a handful of breast or ovarian cancer genes, according to a new economic modeling analysis, identifying at-risk individuals who could benefit from additional imaging tests and cancer-reducing interventions. More...
16 Oct 2019
Image: A new blood test has been developed capable of detecting multiple cancer types. The new test looks for DNA, which cancer cells shed into the bloodstream when they die (Photo courtesy of weeksnews).

New Blood Test Capable of Detecting Multiple Cancer Types

A new blood test in development has shown ability to screen for numerous types of cancer with a high degree of accuracy, a trial of the test shows. In study, test proved able to detect and localize more than 20 types of cancer with a high degree of accuracy. More...
16 Oct 2019
Image: In acute myeloid leukemia (AML), defective blood cells (stained purple) are present. When the cells have a double mutation of both the IDH2 and SRSF2 genes (bottom right), the number of defective cells rises considerably, indicating a more lethal disease (Photo courtesy of Cold Spring Harbor Laboratory).

Two Different Mutations Identified as Cause of AML

Two very different mutations have been identified as unexpected partners in crime for causing the blood cancer acute myeloid leukemia (AML). Expert analysis helped reveal how this deadly duo is far more common in AML than thought. More...
15 Oct 2019
Image: A test to detect opioid drugs in exhaled breath was developed. In this photograph, a volunteer breathes normally into the human breath sampler. Samples are frozen before being taken to the laboratory for analysis (Photo courtesy of Dr. Cristina Davis, University of California, Davis).

Breath Analysis May Replace Blood Sampling to Monitor Drug Usage

A simple and non-invasive technique to collect exhaled breath condensate (EBC) from chronic pain patients was developed, and its usefulness was confirmed by comparing metabolites in breath and blood samples following use of different analgesic opioid drugs. More...
14 Oct 2019
Image: The Quant-iT PicoGreen dsDNA assay kit (Photo courtesy of Thermo Fisher Scientific).

Stunted Microbiota and Opportunistic Pathogen Colonize C-Section Birth

Immediately after birth, newborn babies experience rapid colonization by microorganisms from their mothers and the surrounding environment. Infants born by Caesarean section have gut microbiomes that differ from those of infants born vaginally, carrying more hospital-associated opportunistic pathogens. More...
10 Oct 2019
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.
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