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Molecular Diagnostics

Image: Upconverting nanoparticles: With the combination of NIR-excitation (980 nanometers) and detection at a lower wavelength, the autofluorescence from biological samples is totally eliminated, and the particles are detectable through tissue sections and even in whole blood (Photo courtesy of Kaivogen Oy)

Novel Rapid Lateral Flow Assay Measures Ovarian Cancer Biomarker CA125

A radically modified lateral flow immunoassay was able to detect the ovarian cancer biomarker glycosylated CA125 in serum samples and rapidly differentiate epithelial ovarian cancer from benign endometriosis and healthy controls. More...
21 Sep 2020
Image: Illustration depicting the marriage of DNA nanotechnology and bioelectronics (Photo courtesy of EatFishDesign)

Biosensing Platform Diagnoses Diseases Through Single Molecule Detection

A new diagnostic approach employs a DNA origami biosensor platform coupled with a nanopore read-out that enables individual biomarker detection. More...
15 Sep 2020
Image: Histopathology of the coronary artery demonstrating an intramural hematoma compressing the vessel lumen from outside from a patient with spontaneous coronary artery dissection (Photo courtesy of Professor Mary N Sheppard, MBBCh FRCPath).

Genetics Influence Risk for Spontaneous Coronary Artery Dissection

Spontaneous coronary artery dissection (SCAD) is an increasingly recognized cause of myocardial infarction (MI) in young and otherwise healthy women, for which the etiology is incompletely understood. More...
14 Sep 2020
Image: Using advanced biochemical analysis of patient serum, researchers found signatures that help predict which patients are at highest risk of dying from S. aureus bacteremia, a blood infection (Photo courtesy of University of California, San Diego)

Proteomics-Based Diagnostic Test Predicts Risk of Dying from Staphylococcus aureus Bacteremia

A diagnostic approach that integrates proteomic and metabolomic techniques enabled the identification of biomarkers that could predict which patients had the highest risk of dying from Staphylococcus aureus bacteremia. More...
14 Sep 2020
Image: Newborn Exome Sequencing Could Augment Other Newborn Screening Approaches (Photo courtesy of Sushytska).

Sequencing Could Augment Other Newborn Screening Methods

Newborn screening (NBS) was established as a public health program in the 1960s and is crucial for facilitating detection of certain medical conditions in which early intervention can prevent serious, life-threatening health problems. More...
14 Sep 2020
Image: Schematic diagram of fetal and maternal DNA as studied in the detection and characterization of jagged ends of double-stranded DNA in plasma (Photo courtesy of Ariosa Diagnostics).

Jagged Ends of Double-Stranded DNA Characterized

Cell-free DNA in plasma has been used for noninvasive prenatal testing and cancer liquid biopsy. The physical properties of cell-free DNA fragments in plasma, such as fragment sizes and ends, have attracted considerable recent interest. More...
10 Sep 2020
Image: Illustration depicting tumor formation in the tissues of the oropharynx (Photo courtesy of Wikimedia Commons)

MicroRNA-Based Liquid Biopsy Assay for Early Diagnosis of Head and Neck Cancer

A microRNA-based liquid biopsy assay has been developed that enables early diagnosis of oropharyngeal squamous cell carcinoma, a disease causing hundreds of thousands of fatalities each year. More...
09 Sep 2020
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.