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Molecular Diagnostics

Image: Image of the paper-based isotachophoresis (ITP) device that isolates, enriches, and detects exosomes from a prostate cancer cell line (Photo courtesy of Washington State University)

Sensitive Separation Device Enables Diagnostic Analysis of Cancer Exosomes

A novel separation technique that combines isotachophoresis with paper-based lateral flow chromatography was used to isolate and characterize cancer exosomes and exosome biomarkers in serum samples. More...
15 Jun 2020
Image: Myeloid-derived suppressor cells in the tumor microenvironment have been observed in a variety of solid tumors (Photo courtesy of BMS Immuno-Oncology).

Tumor Mutation and Immune Microenvironment Revealed in Colorectal Cancer

Most colorectal cancers are due to old age and lifestyle factors, with only a small number of cases due to underlying genetic disorders. Other risk factors include diet, obesity, smoking, and lack of physical activity. Dietary factors that increase the risk include red meat, processed meat, and alcohol. More...
10 Jun 2020
Image: Micrograph of a coronary artery with the most common form of coronary artery disease (atherosclerosis) and marked luminal narrowing (Photo courtesy of Wikimedia Commons)

Polygenic Risk Scores Highlight Potential for Developing Coronary Artery Disease

By combining a polygenic risk score with results of more traditional clinical tests, it was possible to identify individuals at high-risk for development of coronary artery disease (CAD) who had not been recognized through standard clinical evaluations alone. More...
09 Jun 2020
Image: The Bio-Rad CFX96 Real-Time PCR Platform (Photo courtesy of Nanyang Technological University).

Streamlined Assay Improves Prenatal Detection of Alpha-Thalassemia

Alpha-Thalassemia is a group of recessively inherited hemoglobin (Hb) disorders that result from decreased or absent synthesis of α-globin chains, affecting up to 5% of the world's population, mainly prevalent in the Mediterranean coastal countries, Southeast Asia, some African countries, and southern China. More...
09 Jun 2020
Image: Photomicrograph of pediatric pilocytic astrocytoma, a brain tumor, showing the characteristic bipolar cells with long hair-like processes (Photo courtesy of Nephron)

Precision Oncology Confers Clinical Benefit in Relapsed Pediatric Cancer

The Individualized Therapy for Relapsed Malignancies in Childhood (INFORM) registry has been created to help develop precision medicine-based approaches and to analyze their effectiveness across high-risk relapsed or refractory pediatric cancers. More...
08 Jun 2020
Image: Transmission electron microscope image showing SARS-CoV-2, the virus that causes COVID-19 (Photo courtesy of [U.S.] National Institute of Allergy and Infectious Diseases)

Blood Protein Biomarkers Predict Outcome of a Patient’s COVID-19 Infection

A panel of blood biomarkers in patients with COVID-19 has demonstrated the potential to predict the severity of their symptoms and likely outcome of the infection. More...
08 Jun 2020
Image: The Cepheid Xpert Xpress SARS-CoV-2 test was compared favorably with other molecular diagnostic tests (Photo courtesy of Cepheid).

Study Evaluates Molecular Diagnostics Tests for SARS-CoV-2

The explosion of COVID-19 cases in the USA has highlighted the critical role diagnostic testing plays in medical and public health decision making in containing and mitigating the SARS-CoV-2 pandemic. More...
04 Jun 2020
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.