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Molecular Diagnostics

Image: Islet of Langerhans from the pancreas of a patient with chronic Type 1 diabetes of 19 years duration. A single lobe of the pancreas was found to contain islets rich in residual beta cells (alpha cells in red; beta cells in green) (Photo courtesy of Diapedia).

Biomarker Identified for Early Beta-Cell Death in Type 1 Diabetes

Beta cells in the pancreas produce insulin and their death is a key feature of Type 1 diabetes, and that loss starts long before diagnosis. However, there has been no straightforward way to measure that early loss. More...
18 Sep 2019
Image: The Parsortix system for collection of circulating tumor cells (Photo courtesy of ANGLE plc).

Automated Collection of CTCs Improves Prostate Cancer Diagnosis

A recent paper described the benefits of circulating tumor cell (CTC) analysis for improving the diagnosis of aggressive prostate cancer beyond currently used PSA (prostate specific antigen) measurement, biopsy and/or MRI imagery. More...
16 Sep 2019
DIASOURCE (A Biovendor Company)
Image: Zika virus particles (red) shown in African green monkey kidney cells (Photo courtesy of the [U.S.] National Institute of Allergy and Infectious Diseases).

Zika Virus Test Kit Receives American Marketing Approval

A blood test designed to confirm diagnosis of Zika virus infection has been granted 510(k) marketing approval that allows it to be sold in the United States. More...
16 Sep 2019
Image: G-protein-coupled receptor mechanism (Photo courtesy of Wikimedia Commons).

Autoimmune Antibody Identified as Biomarker for Tachycardia Syndrome

Results published in a recent paper suggested that postural orthostatic tachycardia syndrome (POTS) was probably an autoimmune disorder and may boost the development of a simple blood test to diagnose the condition. More...
16 Sep 2019
Image: The RIDAQUICK Norovirus test is a quick qualitative immunochromatographic test for determining genogroup 1 (GG I) and genogroup 2 (GG II) noroviruses in stool samples (Photo courtesy of R-Biopharm AG).

Human Intestinal Enteroids Used to Detect Norovirus Infectivity

Human norovirus accounts for 18% of acute gastroenteritis cases worldwide. Molecular nucleic acid tests, such as real-time reverse transcription polymerase chain reaction (rRT-PCR), are widely used for laboratory diagnosis of norovirus RNA in clinical samples. More...
12 Sep 2019
Image: A photomicrograph showing Trypanosoma brucei gambiense in a blood film. This parasitic protozoan species causes African trypanosomiasis (or sleeping sickness) in humans via the tsetse fly (Photo courtesy Alain G.C. Buguet).

Detergent-Enhanced LAMP Detects African Trypanosome in CSF

Human African trypanosomiasis is a fatal disease, if untreated, spread by bloodsucking tsetse flies. These protozoan parasites first enter the lymph and blood to invade many organ systems, the early stage sleeping sickness. More...
12 Sep 2019
Image: Drumstick-shaped Clostridioides difficile bacilli as they appear in scanning electron microscopy (Photo courtesy of Kateryna Kon, PhD).

Fungus-Associated Bacteriome Associated with C. difficile Infection

Clostridioides difficile infection (CDI), the most common etiology of nosocomial infectious diarrhea, is caused by an intestinal dysbiosis that is virtually always attributable to antibiotics. This causes one of the most common hospital-acquired infections in the USA. More...
11 Sep 2019
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