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Molecular Diagnostics

Image: RNA from all bodily organs is present in the blood and can be used to detect pregnancy complications (Photo courtesy of Illumina).

Early-Onset Preeclampsia Risk Reflected in Circulating Maternal Transcripts

Preeclampsia is a poorly understood pregnancy-associated disorder. Often marked by hypertension, preeclampsia can lead to severe complications including internal bleeding, seizures, stroke, premature birth, and death. More...
13 Jul 2020
Image: The Idylla system is a fully-automated, real-time polymerase chain reaction (PCR) based molecular testing system designed to offer results in a minimal amount of time (Photo courtesy of Biocartis).

Rapid Genomic Profiling of Colon Cancers Improves Therapy Selection

Colorectal cancer is a malignant tumor arising from the inner wall of the large intestine (colon) or rectum. Colorectal cancer is the third leading cause of cancer in both men and women in the USA. Most colorectal cancers develop from polyps. Removal of colon polyps can aid in the prevention of colorectal cancer. More...
09 Jul 2020
Image: Illustration depicts a healthy liver (left) and a liver with cirrhosis (Photo courtesy of [U.S.] National Institute of Diabetes and Digestive and Kidney Diseases)

Gut Microbiome Metabolomic Profiles Are Diagnostic for Liver Diseases

Liver disease researchers have developed a noninvasive method to diagnose nonalcoholic fatty liver disease (NAFLD) and predict progression to cirrhosis by analyzing metabolomic profiles produced by the microorganisms living in the gut (the microbiome). More...
08 Jul 2020
Image: Single-cell copy number profiling: Chromium Single Cell CNV Solution provides a comprehensive, scalable solution for revealing genome heterogeneity and understanding clonal evolution (Photo courtesy of 10X Genomics).

DNA Sequencing Technique Unravels Genetic Diversity of Cancer Tumors

The ability to sequence the genome of a tumor has revolutionized cancer treatment by identifying drivers of cancer at the molecular level. However, understanding the genetic diversity of individual cells within a tumor and how that might impact the disease progression has remained a challenge, due to the current limitations of genomic sequencing. More...
07 Jul 2020
Image: Typical or `classical` ALS involves neurons in the brain (upper motor neurons) and in the spinal cord (lower motor neurons) (Photo courtesy of Wikimedia Commons)

An Eight MicroRNA Biomarker Panel for Diagnosis of ALS

A team of neurodegenerative disease researchers has identified eight microRNA sequences from enriched exosome extractions of blood plasma that consistently and significantly differentiate patients with amyotrophic lateral sclerosis/motor neuron disease (ALS/MND) from healthy controls. More...
07 Jul 2020
Image: The Bioanalyzer RNA 6000 Nano assay provides reliable and reproducible characterization of total RNA and mRNA from multiple sample types (Photo courtesy of Agilent Technologies).

RNA Sequencing as Alternative to Immunohistochemistry in Cancer Diagnostics

The conventionally used method for cancer diagnostics relies on immunohistochemical dyeing of tumor tissue sections. It allows detecting the presence and measuring the concentration of marker proteins characterizing malignant growths. The resulting microscope images indicate whether the tumor is malignant and what its molecular type is. This information is crucial for selecting the right therapy. More...
06 Jul 2020
Image: The Chemagic 360 extracts DNA and uses transiently magnetized rods to attract the beads after binding to the nucleic acids (Photo courtesy of PerkinElmer).

Blood Group Locus Contributes to COVID-19 Severity Risk

There is considerable variation in disease behavior among patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes coronavirus disease 2019 (COVID-19). More...
02 Jul 2020
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.
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