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Molecular Diagnostics

A heat-map, where red shows high levels of a compound, and blue shows low levels of a compounds, reveals the link between certain metabolites and dementia. Compounds in sub-group A were typically higher in dementia patients and lower in healthy elderly people. Compounds in sub-group B-E showed the opposite effect (Photo courtesy of Okinawa Institute of Science and Technology)

Metabolic Biomarker Panel Shows Promise for Diagnosis of Dementia

A biomarker panel based on five groups of metabolites was shown to be potentially useful for diagnosis and therapy of various forms of dementia, such as Alzheimer’s disease. More...
22 Sep 2021
Image: Acute lymphoblastic leukemia: bone marrow aspirate smear reveals increased blasts which are small to medium in size with high nuclear-to-cytoplasmic ratios, round to irregular nuclei, smooth chromatin, and scant basophilic agranular cytoplasm. Some background maturing myeloid cells are also present in this case (Photo courtesy of Karen M. Chisholm, MD, PhD)

Acute Lymphoblastic Leukemia Risk Linked to Genetically Mediated Increase in Lymphocytes

Acute lymphoblastic leukemia (ALL) is a cancer of the lymphoid line of blood cells characterized by the development of large numbers of immature lymphocytes. As an acute leukemia, ALL progresses rapidly and is typically fatal within weeks or months if left untreated. More...
15 Sep 2021
Image: The autoimmune signature of hyperinflammatory multisystem inflammatory syndrome in children (Photo courtesy of Cedars-Sinai Medical Center)

Biomarkers Found for COVID-19 MIS-C Condition in Children

Multisystem Inflammatory Syndrome in Children (MIS-C) manifests as a severe and uncontrolled inflammatory response with multiorgan involvement, occurring weeks after SARSCoV-2 infection. More...
13 Sep 2021
Image: High magnification micrograph of Castleman disease, hyaline vascular variant, also known as angiofollicular lymph node hyperplasia and giant lymph node hyperplasia (Photo courtesy of Wikimedia Commons)

Blood Biomarkers Predict Likelihood of Castleman Disease Treatment Response

Biomarkers have been found in the blood that can be used to predict which patients with idiopathic multicentric Castleman disease are more likely to respond to siltuximab, the only [U.S.] Food and Drug Administration (FDA) approved treatment for the disorder. More...
13 Sep 2021
Image: Schematic representation of cancer-related biomolecules such as cells, proteins, nucleic acids, miRNA and microvesicles circulating into the bloodstream, and collection of these biomarkers by liquid biopsy (Photo courtesy of University of Florence)

Liquid Biopsy Assay Evaluated for Early Detection of Gastric Cancer

Gastric cancer (GC) is the fourth most-commonly diagnosed cancer, and the third leading cause of cancer-associated mortality worldwide. Despite improvements in treatment modalities, the prognosis for advanced GC following curative resection remains poor. More...
08 Sep 2021
Image: Blood type is determined, in part, by the ABO blood group antigens present on red blood cells (erythrocytes) (Photo courtesy of Wikimedia Commons)

Genomics Approach Links ABO Blood Type to Inflammatory and Cardiovascular Diseases

A genomics approach that supplements classical blood typing procedures connects blood type phenotype to a large set of common inflammatory and cardiovascular diseases. More...
07 Sep 2021
Image: Scanning electron micrograph of a human T-cell from the immune system of a healthy donor (Photo courtesy [U.S.] National Institute of Allergy and Infectious Diseases)

Immune Cell Biomarker Predicts Response to Treatment with Checkpoint Inhibitor Drugs

A molecular signature based on an immune cell surface protein is a potential route toward determining a cancer patient’s response to treatment with checkpoint inhibitor drugs. More...
06 Sep 2021
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.
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