Molecular Diagnostics
Immune Cells in Cerebrospinal Fluid Predict Response to Immunotherapy
Immune checkpoint inhibitors including anti-PD1, anti-PD-L1, and anti-CTLA4, have shown significant clinical benefits in patients with progressive or metastatic solid tumors, including some brain metastasis. Notably, these immune-based therapies have improved outcomes for some of those suffering from lung cancer and melanoma. More...22 Mar 2021
Pediatric Pancreatic Cancer Diagnosed from cfDNA Fragments in Urine
Although rare, pancreatoblastoma is the most common pancreatic tumor of young children. Carcinoma of acinar cell origin has rarely been reported in older children. Ductal adenocarcinoma and its many variants are the most common pancreatic tumors in adults, but these are exceedingly rare in children. More...17 Mar 2021
Clonal Hematopoiesis and Recurrent Mutations Identified in Blood Cancers
Clonal hematopoiesis of indeterminate potential (CHIP) is characterized by detectable hematopoietic-associated gene mutations in a person without evidence of hematologic malignancy. Somatic mutations at hotspots (genetic loci observed to be frequently mutated across cancer patients) often drive or contribute to cancer pathogenesis. More...16 Mar 2021
Liquid Biopsy Technique Detects Circulating Tumor Cells in Patients with Non-Small Cell Lung Cancer
A liquid biopsy technique based on hexokinase-2, a key enzyme in glucose metabolism, is able to detect circulating tumor cells (CTCs) in patients with non-small cell lung cancer (NSCLC). More...16 Mar 2021
Analysis of Urinary Exosome RNA Can Diagnose Kidney Transplant Rejection
A panel of mRNA signatures derived from urinary exosomes was shown to be a powerful and noninvasive tool to screen for the body’s rejection of a kidney allograft (a transplant from a genetically non-identical donor). More...15 Mar 2021
Whipple’s Disease Pathogen Found in International Diarrhea Patients
Tropheryma whipplei is the causative agent of Whipple’s disease. The organism has also been detected in the feces of healthy or asymptomatic persons and in the feces of patients with diarrhea. Symptoms tend to develop slowly over many years in most people with this disease. More...11 Mar 2021
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In Other News
Five Genes Help Predict Lewy Body Dementia
Low Lymphocyte Counts Linked to More Severe Sarcoidosis Inflammation
Childrens’ Urinary MicroRNAs Predict Future Development of Heart or Kidney Diseases
Clinical Germline Testing Evaluated for Pediatric Cancer Patients
Genetic Risk of Inflammatory Bowel Disease Appears Distinct in African Americans
ctDNA Provides Prognostic Clues in Advanced BRAF-Mutated Melanoma Cases
Rapid Lateral Flow Assays Detect COVID-19 Variants and Differentiate COVID-19 from Other Respiratory Viral Diseases
Elevated Plasma Levels of Glial Fibrillary Acidic Protein Indicate Increased Alzheimer’s Risk
Pulse-Controlled Amplification Tested for Infectious Disease Diagnostics
22-Gene Genomic Classifier Validated in Recurrent Prostate Cancer Patients
Plasma or Urine Liquid Biopsy Tests May Guide Colorectal Cancer Treatment
Proteogenomic and Metabolomic Studies Characterize Human Glioblastoma
Study Confirms Value of the MyProstateScore Urine Test for Prostate Cancer Screening
Next Generation Sequencing Finds More Gene Mutations for Leukemia
Exome Sequencing Identified Pathogenic Variants in Cerebral Palsy Patients
Analysis of Cell-free DNA in the Blood May Replace Examination of Biopsy Specimens for Disease Diagnosis
NanoString Technology Modernizes Liposarcoma Diagnostics
TFP Inhibitor Levels Elevated in Bleeding Tendency Patients
Prolonged Maternal Zika Viremia Evaluated for Adverse Perinatal Outcomes
Early Plasma Biomarkers Discovered for Alzheimer's Disease
TAP1 Gene Polymorphisms Associated with Recurrent Respiratory Papillomatosis
Liquid Biopsy Allows Monitoring of COVID-19 Damage to Cells, Tissues, and Organs
Blood Test Detects Early Colorectal Adenomas
Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.
