Molecular Diagnostics
Inherited Causes of Clonal Hematopoiesis in Multiplicity of Whole Genomes
The age-related acquisition of somatic mutations that lead to clonal expansion in regenerating hematopoietic stem cell populations has recently been associated with both hematological cancer and coronary heart disease, and this phenomenon is termed clonal hematopoiesis of indeterminate potential (CHIP). More...29 Oct 2020
Single-Molecule Tethering Detects Nucleic Acids and Microorganisms
Detection of microbial nucleic acids in body fluids has become the preferred method for rapid diagnosis of many infectious diseases. However, culture-based diagnostics that are time-consuming remain the gold standard approach in certain cases, such as sepsis. More...29 Oct 2020
Novel Method Reclaims Resolution of Single-Cell RNA-Seq
Single-cell RNA sequencing (scRNA-seq) is a powerful tool to characterize cells. Current scRNA-seq platforms, despite offering high throughput, are inefficient and provide low resolution among distinct cell states and molecular features. More...28 Oct 2020
Germline Testing After Tumor Sequencing Uncovers Clinically Actionable Variants
Genetic counseling and germline testing are recommended for patients with cancer who have suspected hereditary disease based on each patient’s presentation and family history. Separately, tumor DNA sequencing is increasingly used, most often in patients with advanced disease. More...27 Oct 2020
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Large Genome-Wide Association Study Identifies Novel Abdominal Aortic Aneurysm Risk Loci
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.