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Molecular Diagnostics

Image: This illustration reveals ultrastructural morphology exhibited by the coronavirus that causes COVID-19. Note the spikes that adorn the outer surface of the virus, which impart the look of a corona surrounding the virion (Photo courtesy of [U.S.] Centers for Disease Control and Prevention)

Serum Amyloid A Levels Linked to Likelihood of Developing Severe COVID-19

Results of research papers published during the current pandemic suggest that increased levels of the blood biomarker serum amyloid A predict development of severe or fatal forms of COVID-19. More...
26 Apr 2021
Image: A 47-year-old man with mucormycosis and (b) electron micrograph of his skin showing sporangia of Mucorales fungi: non-apophysate sporangia with pronounced columellae and conspicuous collarette at the base of the columella following sporangiospore dispersal (Photo courtesy of IntechOpen Limited)

Different Methods Compared for Isolating Fungal DNA

Mucormycosis (previously called zygomycosis) is a serious, but rare fungal infection, caused by a group of molds called mucormycetes. These molds live throughout the environment. Mucormycosis mainly affects people who are immunocompromised or diabetic. More...
26 Apr 2021
Image: The QX200 Droplet Digital Polymerase Chain Reaction (PCR) Systems provide ultrasensitive and absolute nucleic acid quantification. (Photo courtesy of Bio-Rad)

Digital PCR Improves BCR-ABL1 Detection in Chronic Myeloid Leukemia

Specific targeting of the Bcr-Abl1 enzyme by tyrosine kinase inhibitors (TKI) revolutionized the management of chronic myeloid leukemia (CML) to the point that TKIs can offer near normal life expectancy for CML patients. More...
22 Apr 2021
Image: Histopathology from a transurethral biopsy of urothelial carcinoma of the urinary bladder (Photo courtesy of KGH)

RNA-Sequencing Predicts Immunotherapy Success in Bladder Cancer

Urothelial carcinoma, also known as transitional cell carcinoma (TCC), is by far the most common type of bladder cancer. Urothelial cells also line other parts of the urinary tract, such as the part of the kidney that connects to the ureter (called the renal pelvis), the ureters, and the urethra. More...
22 Apr 2021
Image: Representation of the molecular structure of the cathepsin B (catB) protein (Photo courtesy of Wikimedia Commons)

An Ultrasensitive Assay for Measurement of Levels of Cathepsin B in the Blood

A novel digital enzyme-linked immunosorbent assay (ELISA) has been developed for the differential detection of cathepsin B from samples of serum or plasma. More...
21 Apr 2021
Image: HIV assembling on the surface of an infected macrophage. The HIV virions have been marked with a green fluorescent tag and then viewed under a fluorescent microscope (Photo courtesy of Wikimedia Commons)

A Method for Accurately Assessing the Latent Virus Reservoir in Chronic HIV Patients

A modified version of the PCR test can determine the quantity and quality of inactive human immunodeficiency virus (HIV) in the genes of individuals suffering from chronic HIV. More...
20 Apr 2021
Image: Darkfield photomicrograph (magnified 400x) showing the presence of the spirochaete Borrelia burgdorferi, which is the pathogen that causes Lyme disease (Photo courtesy of [U.S.] Centers for Disease Control and Prevention via Wikimedia Commons)

Sensitive PCR Test Detects Early Stage Lyme Disease

A highly sensitive blood test detects the bacteria that causes Lyme disease in early stages of the infection, when treatment can prevent the development of serious or fatal consequences of the chronic disease. More...
19 Apr 2021
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