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Clinical Chemistry

Image: The Mindray CL-2000i Chemiluminescence Immunoassay System (Photo courtesy of Mindray Bio‐Medical Electronics).

Chemiluminescence Anti‐Müllerian Hormone Assay Performance Characterized

Müllerian hormone (AMH), a dimeric glycoprotein hormone, is a member of the transforming growth factor‐β superfamily that plays a predominant role in male and female sexual differentiation. More...
18 Mar 2021
Image: The Elecsys high-sensitivity cardiac troponin T (hs-cTnT) assay: as immunological method for the in vitro quantification of cardiac troponin T in human serum and plasma (Photo courtesy of Roche Diagnostics).

Cardiac Troponins Assessed for Acute Heart Failure

Heart failure (HF) is a clinical syndrome characterized by dyspnea, peripheral edema and fatigue. Diagnosing HF can be difficult due to overlapping symptoms with other conditions, and the phenotype of HF varies due to a broad spectrum of underlying pathophysiology. More...
17 Mar 2021
Image: In-vitro misfolded α-synuclein amplification by real-time quaking-induced conversion (Photo courtesy of University of Edinburgh).

CSF Biomarker Flags Parkinson's Pathology Much Earlier

Isolated rapid-eye-movement (REM) sleep behavior disorder (IRBD) can be part of the prodromal stage of the α-synucleinopathies Parkinson's disease and dementia with Lewy bodies years before clinical symptoms appear. More...
16 Mar 2021
Image: The principle of SOMAscan Assay that allows for the simultaneous detection of 1,300 human proteins using SOMAmer (Slow Off-rate Modified Aptamer) protein-binding reagents (Photo courtesy of SomaLogic).

Blood Biomarker Discovered for Autism Spectrum Disorder

Autism spectrum disorder (ASD), a heterogeneous neurodevelopmental disorder, is characterized by deficits in social communication and social interaction, with restricted, repetitive patterns of behavior, interests, or activities. ASD impacts at least one out of every 59 children in the USA, although this is likely an underestimation. More...
11 Mar 2021
Image: An enzyme-linked immunosorbent assay (ELISA) measured serum 14–3-3η levels and evaluated in juvenile idiopathic arthritis (Photo courtesy of Quest Diagnostics).

Biomarker Protein Investigated in Juvenile Idiopathic Arthritis

Juvenile idiopathic arthritis (JIA) is the most common pediatric rheumatologic disease that may persist into adulthood and impact quality of life. The diagnosis is mainly based on clinical assessment rather than relying on laboratory testing. More...
09 Mar 2021
Image: Schematic diagram of Type 1 Diabetes (TID). Immune Response to Insulin Could Identify and Help Treat Those at Risk for TID (Photo courtesy of Harvard Medical school).

Immune Response to Insulin Identifies Risk of Juvenile-Diabetes

Type 1 diabetes (T1D), also known as juvenile diabetes, is a form of diabetes in which very little or no insulin is produced by the islets of Langerhans (containing β-cells) in the pancreas. Insulin is a hormone required for the body to use blood sugar. More...
08 Mar 2021
Image: The Atellica CH 930 Immunoassay & Clinical Chemistry Analyzer (Photo courtesy of Siemens Healthcare).

Fibrinogen to Albumin Ratio Reflects ANCA‐Associated Vasculitis Activity

Microscopic polyangiitis (MPA), granulomatosis with polyangiitis (GPA) and eosinophilic granulomatosis with polyangiitis (EGPA) belong to a group of anti-neutrophil cytoplasmic antibody (ANCA)‐associated vasculitis (AAV). More...
04 Mar 2021
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The Clinical Chemistry channel updates the reader on tests, techniques, and research in the field - from routine assays to specialized tests on blood, urine, enzymes, lipids, hormones and more.
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