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Clinical Chemistry

Image: Prototype of ATP and Lactate sensor (Photo courtesy of Hokkaido University)

Electrochemical Enzyme-Based Blood ATP and Lactate Sensor Monitors Disease Severity

Scientists have developed a prototype sensor that could help doctors rapidly measure adenosine triphosphate (ATP) and lactate levels in blood samples from patients, aiding in the rapid assessment of the severity of diseases. More...
28 Feb 2022
Image: Electroanalytical technique uses gold-containing ternary nanocomposites (Photo courtesy of Unsplash)

Gold Nanoparticle-Based Electrode Marks Breakthrough in Urinalysis Disease Detection Methodology

Using gold-containing ternary nanocomposites, researchers have developed a novel electroanalytical technique with key diagnostic implications. More...
25 Feb 2022
Image: The Orbitrap Fusion Lumos Tribrid Mass Spectrometer is an advanced performance mass spectrometry system that can be upgraded to even higher resolution (1M), additional dissociation capabilities (UVPD and ETD), and a unique internal calibration (IC) (Photo courtesy of Thermo Fisher Scientific)

Biomarker Panel For Risk of Early Respiratory Failure Following Hematopoietic Cell Transplantation

This study identified and validated ST2, WFDC2, IL6 and TNFR1 as risk biomarkers for respiratory failure and related mortality post-HCT. More...
23 Feb 2022
Image: The LIAISON XL is a fully automated chemiluminescence analyzer, performing complete sample processing as well as measurement and evaluation (Photo courtesy of Medical Laboratory Observer)

Calprotectin Fecal Assay Adapted for Serum Samples

Calprotectin is a calcium-binding protein that can be measured in serum, plasma, and feces. Increased serum and plasma calprotectin concentrations have been found in chronic inflammatory rheumatic disorders. An analytical and clinical evaluation of the DiaSorin Liaison® fecal Calprotectin assay using LIAISON® XL was performed. More...
16 Feb 2022
Image: Serum Glucose Identifies Hospitalized Stroke Patients At Greatest Risk For Recurrence (Photo courtesy of Blood Tests London)

Serum Glucose Identifies Hospitalized Stroke Patients at Greatest Risk for Recurrence

Presence of hyperglycemia at hospital admission for stroke was linked with elevated risk for subsequent stroke by 90 days, an increase that dual antiplatelet therapy seemingly failed to curtail. More...
14 Feb 2022
Image: The Simoa HD-1 Analyzer was used for measuring plasma biomarkers of dementia (Photo courtesy of Quanterix)

Blood Biomarkers May Distinguish Dementia Disorders

Clinical diagnostics and clinical trials will benefit from scalable non-invasive biomarkers moving beyond positron emission tomography (PET) imaging and cerebrospinal fluid (CSF) analysis to blood based assays. More...
09 Feb 2022
Image: A blood test for neurofilaments can differentiate Amyotrophic lateral sclerosis (ALS) subgroups and ALS from common diagnostic mimics (Photo courtesy of The Association for Frontotemporal Degeneration)

Simpler and Reliable ALS Diagnosis Enabled With Blood Tests

Amyotrophic lateral sclerosis (ALS) is an adult onset fatal neurodegenerative syndrome characterized by the insidious onset of progressive motor symptoms and signs secondary to the loss of upper and lower motor neurons and their tracts. More...
08 Feb 2022
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The Clinical Chemistry channel updates the reader on tests, techniques, and research in the field - from routine assays to specialized tests on blood, urine, enzymes, lipids, hormones and more.