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Clinical Chemistry

Image: Computerized tomography (CT) scans from two different patients with pulmonary nodules. The arrow on the left points to a benign (noncancerous) nodule, while the arrow on the right shows a small lung cancer (Photo courtesy of The Lung Cancer Center at The Valley Hospital).

Liquid Biopsy Can Rule Out Early-Stage Lung Cancer

Lung nodules are a diagnostic challenge with an estimated yearly incidence of 1.6 million in the USA. The majority of these patients have benign lung nodules; however, there are significant costs, morbidity and mortality associated with the invasive biopsies needed to determine which nodules are cancerous. More...
05 Apr 2018
Image: The Architect i2000SR immunoassay analyzer (Photo courtesy of Abbott Diagnostics).

Chronic Fatigue Syndrome Linked to Thyroid Levels

Chronic fatigue syndrome (CFS) is a common disease marked by lengthy spells of weakness, fatigue and depression. Its diagnosis is predominantly based on symptoms and on ruling out any underlying medical condition, rather than on laboratory tests and physical examination. More...
04 Apr 2018
Image: The cobas e 601 immunology analyzer (Photo courtesy of Roche Diagnostics).

Biomarker Assay Recommended for Heart Failure Diagnosis

The value of a biomarker to accurately diagnose or rule out acute heart failure in patients seen for shortness of breath at hospital emergency departments has been validated. More...
02 Apr 2018
Image: A histopathology of the diabetic kidney showing the thickening of the mesangial basement membrane and matrix with nodular glomerular sclerosis and intercapillary sclerosis (Photo courtesy of the University of Antioquia).

CKD May Occur Before Diabetes Diagnosis

Doctors have long known that patients with diabetes are at risk for kidney disease, and while chronic kidney disease (CKD) is regularly evaluated among patients with diabetes, kidney function may be significantly impaired before diabetes is diagnosed. More...
28 Mar 2018
Image: A cardiac troponin I sandwich enzyme-linked immunosorbent assay (ELISA) kit (Photo courtesy of Cell Biolabs).

New Heart Attack Test Better Informs Underlying Condition

The serum troponin assay is the biochemical gold standard for detecting myocardial infarction (MI). A major diagnostic issue is that some believe troponin levels can rise with reversible injury, in the absence of radiologically detectable infarct. More...
27 Mar 2018
Image: The GC-2010 gas chromatograph used for calculating the Omega-3 Index (Photo courtesy of Shimadzu).

Omega-3 Levels Predict Death Risk Better Than Serum Cholesterol

The value of measuring blood levels of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) omega-3 fatty acids to assess an individual's risk for developing certain disease has been investigated. More...
27 Mar 2018
Image: Human Amyloidβ Oligomers enzyme-linked immunosorbent assay (ELISA) Kit (Photo courtesy of IBL International).

Alzheimer Disease CSF Biomarker Used in Clinical Setting

Analysis of cerebrospinal fluid (CSF) is one of the key tools for the state-of-the-art differential diagnosis of dementias. Dementia due to Alzheimer’s disease (AD) is characterized by elevated CSF levels of total Tau (tTau) and phospho-181-Tau (pTau) and low CSF amyloid-β42 (Aβ42). More...
27 Mar 2018
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The Clinical Chemistry channel updates the reader on tests, techniques, and research in the field - from routine assays to specialized tests on blood, urine, enzymes, lipids, hormones and more.