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BioResearch

Image: The neuromuscular junction is the synapse where motor neurons communicate with muscle to initiate voluntary movement. A healthy neuromuscular junction (yellow) is characterized by perfect apposition between the motor neuron (green) and nicotinic acetylcholine receptors on the muscle (red). This synapse is damaged early in ALS, a change believed to contribute the onset and progression of the disease (Photo courtesy of the Virginia Tech Carilion Research Institute).

Faulty Protein Interaction Disrupts Neuromuscular Junctions and Triggers ALS

Humans and mice are protected from developing amyotrophic lateral sclerosis (ALS) by the action of muscle fibers that secrete and concentrate the fibroblast growth factor binding protein 1 (FGFBP1) at neuromuscular junctions. More...
01 Dec 2016
Image: A micrograph of cells in the thymus, an organ located just above the heart that trains immune T-cells to defend the body against viruses and bacteria (Photo courtesy of the Walter and Eliza Hall Institute).

Study Explains How Protein Complex Mediates T-cell Development

A recent paper extended our understanding of how T-cells develop into critical components of the immune system that are able to fight off pathogens without going out of control and triggering an autoimmune response. More...
30 Nov 2016
Image: Two fluorescent microscopy images of intestinal organoids growing in synthetic hydrogels (Photo courtesy of N. Gjorevski, Ecole Polytechnique Fédérale de Lausanne).

Synthetic Hydrogel System for Growth of Intestinal Organoids

A process for using artificial hydrogel matrices to grow miniature organs (organoids) derived from stem cell precursors was described in a recent paper. More...
30 Nov 2016
Image: The structural model of IL-10 (Photo courtesy of Wikimedia Commons).

Anti-inflammatory Cytokine Prevents Development of Insulin Resistance in Model

The anti-inflammatory cytokine interleukin 10 (IL-10) was found to prevent the age-related development of insulin resistance in the muscles of a genetically engineered mouse model. More...
29 Nov 2016
Image: A photomicrograph of neurons growing in culture. The colors highlight the human tau protein in green, a structural component in red, and the DNA inside the cell nucleus in blue (Photo courtesy of Dr. Lars Ittner, University of New South Wales).

Phosphorylation of Tau Protein Inhibits Amyloid-beta Toxicity in Alzheimer’s Model

A team of Australian Alzheimer's disease (AD) researchers have presented evidence suggesting that phosphorylation of tau protein in the early stages of the disease acts to protect against the toxicity of amyloid-beta (Abeta) plaques, and that this protective effect disappears as the disease progresses. More...
29 Nov 2016
Image: A fibroblast undergoing ferroptosis (Photo courtesy of Helmholtz Zentrum München).

Blocking the Acsl14 Enzyme Prevents Ferroptosis-Linked Cell Death

Inhibiting the enzyme Acsl4 (acyl-CoA synthetase long-chain family member 4), which is involved in fatty acid metabolism, has been postulated to be a viable therapeutic approach to preventing ferroptosis-related diseases. More...
25 Nov 2016
Image: Researchers have created a tissue-engineered model of the lung and trachea to help study disease processes (Photo courtesy of the Children’s Hospital Los Angeles).

Lung and Tracheal Tissue Expected to Aid Respiratory Disease Research

By modifying a technique for growing cultured intestinal tissue, researchers have developed a tissue-engineered model of the lung and trachea, which contains the diverse cell types present in the human respiratory tract. More...
25 Nov 2016
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BioResearch brings the latest research news on the genome, proteome, metabolome, on drug discovery, and therapeutics. Biotech researchers, lab administrators, technologists, drug manufacturers, and suppliers can find the latest research news and information related to their fields of endeavor here.