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BioResearch

Image: A scanning electron micrograph (SEM) showing Salmonella enterica serotype Typhimurium (red) infecting human cells (yellow) (Photo courtesy of the [U.S.] NIAID Biodefense Image Library).

Salmonella-Based Nanoparticles Suppress Growth of Multidrug Resistant Tumors

Gold nanoparticles were used to transport the Salmonella enterica serotype Typhimurium protein SipA into cancer cells where it decreased the amount of the P-glycoprotein multidrug resistance transporter and suppressed tumor growth. More...
06 Sep 2016
Image: An artist\'s depiction of urushiol (in green), the active ingredient in poison ivy, entrapped by CD1a molecule (in pink), which mediates the inflammatory response (Photo courtesy of Monash University).

CD1a on Langerhans Cells Controls Some Types of Skin Inflammation

A team of Australian and American researchers showed that skin inflammation caused by contact with plants such as poison ivy or poison sumac was regulated by the skin cell surface glycoprotein CD1a. More...
06 Sep 2016
Image: In a mouse model of Alzheimer\'s disease, raising levels of neuregulin-1 (right) lowers a marker of disease pathology in a part of the brain that controls memory compared with controls (left) (Photo courtesy of the Salk Institute for Biological Studies).

Neuregulin-1 Identified As Potential Alzheimer's Disease Treatment

Overexpression of either type I or type III neuregulin-1 (Nrg1, encoded by the NRG1 gene) improved cognitive deficits and reduced neuropathology in an Alzheimer's disease (AD) mouse model. More...
06 Sep 2016
Image: A lymph node with almost complete replacement by metastatic melanoma (Photo courtesy of Wikimedia Commons).

Malignant Melanoma Releases MicroRNAs to Condition the Dermis Prior to Metastasis

Cancer researchers have discovered that prior to spreading, malignant melanoma sends out packets of microRNAs to induce morphological changes in the dermis to prepare that tissue to receive and transport the cancer cells. More...
01 Sep 2016
Image: A photomicrograph of a nerve cell (the small orange-spotted cell on the far left) from a pigtailed macaque infected with herpes virus (Photo courtesy of the Seattle Children\'s Research Institute).

Novel Monkey Model to Enable Study of Dormant Herpes Infections

A team of molecular virologists has demonstrated the potential of the pigtailed macaque monkey model as a platform to study the implications of dormant herpes viruses on individuals with compromised immune systems. More...
01 Sep 2016
Image: Protective telomeres are augmented by freely diffusing telomerase (Photo courtesy of University of Colorado Cancer Center).

Single Molecule Imaging Reveals How Telomerase Finds and Binds to the Telomere

Genomics researchers have combined the CRISPR/Cas9 gene editing technique with advanced single-molecule imaging technology to demonstrate how the enzyme telomerase finds and attaches to the telomere, the region of repetitive nucleotide sequences at each end of a chromosome, which protects the end of the chromosome from deterioration or from fusion with neighboring chromosomes. More...
31 Aug 2016
Image: The enzyme HtrA1 shown in the image degrades ApoE4, the strongest genetic risk factor for Alzheimer’s disease, providing new information that might eventually lead to new treatments for the neurodegenerative disorder (Photo courtesy of Salk Institute for Biological Studies).

Release of ApoE4 Fragments and Increased Tau Protein Contribute to Risk of Alzheimer's Disease

Results of a recent study suggested that the interaction between apolipoprotein E4 (ApoE4) and the enzyme high-temperature requirement serine peptidase A1 (HtrA1) was linked in some fashion to the development of late onset Alzheimer's disease (AD). More...
31 Aug 2016
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BioResearch brings the latest research news on the genome, proteome, metabolome, on drug discovery, and therapeutics. Biotech researchers, lab administrators, technologists, drug manufacturers, and suppliers can find the latest research news and information related to their fields of endeavor here.
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