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BioResearch

Image: A cross-section of an adult human femur produced by three-dimensional printing (Photo courtesy of Dr. Adam E. Jakus, Northwestern University).

Three-Dimensional Printing Generates Bone Replacement Structures

A team of biomedical engineers adapted three-dimensional printing to manufacture bone transplant structures whose shape could be easily customized, which would be especially useful for the treatment of bone defects in children. More...
14 Oct 2016
Image: Alpha-synuclein aggregates in the brain cells of mice with (top) and without (bottom) the LAG3 protein (Photo courtesy of Dr. Xiaobo Mao, Johns Hopkins University).

Protein Found Blocks Transmission of Cytotoxic Fibrils in Parkinson's Disease Model

Neurodegenerative disease researchers have identified a protein that promotes the spread of toxic alpha-synuclein complexes in the brains of mice serving as a model system for human Parkinson's disease (PD). More...
12 Oct 2016
Image: A three-dimensional (3D) molecular space-filling model of resveratrol (Photo courtesy of Wikimedia Commons).

Mechanism Explains How Resveratrol Reduces Upper Respiratory Inflammation

The red wine component resveratrol reduces inflammation in the upper respiratory tract by enhancing the activity of the protein MyD88 short, a negative regulator of inflammatory signaling pathways. More...
12 Oct 2016
Image: Positive alpha-synuclein staining of a Lewy body from a patient with Parkinson\'s disease (Photo courtesy of Wikimedia Commons).

Bifunctional Dimer Drugs Prove Effective in Parkinson's Disease Yeast Model

A team of Canadian neurodegenerative disease researchers used a yeast model system to identify novel drug compounds that were able to block the misfolding of alpha- synuclein (AS) protein, which characterizes the neurons of patients with Parkinson's disease. More...
11 Oct 2016
Image: An “off-the-shelf” material that can grow in the body has the potential to prevent the need for repeated surgeries in some children with congenital heart defects (Photo courtesy of the University of Minnesota).

Novel Graft Material Grows with Young Transplant Recipients

In a "proof-of-concept" paper, a team of biomedical engineers described a novel "off-the shelf" material for grafting blood vessels that is able to grow and mature along with the young patient recipients. More...
11 Oct 2016
Image: As IBD worsens, levels of the gene regulator EZH2 increase, lowering numbers of protective Paneth cells (Photo courtesy of Sanford Burnham Prebys Medical Discovery Institute).

Maintaining Normal Paneth Cell Levels Prevents Intestinal Bowel Disease

The enzyme PKC-lamda/iota (protein kinase C-lamda/iota) plays a critical role in the intestinal epithelium where it influences development of inflammatory diseases and cancer through its regulation of Paneth cell metabolism. More...
06 Oct 2016
Image: A histopathological image of cerebral glioblastoma with Hematoxylin and esoin stain (Photo courtesy of Wikimedia Commons).

Blocking Pair of Metalloproteases Halts Brain Tumor Growth

A team of British cancer researchers has identified the metalloprotease enzymes ADAM10 and ADAM17 as potential therapeutic targets for the treatment of glioblastoma multiforme (GBM) brain tumors. More...
05 Oct 2016
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BioResearch brings the latest research news on the genome, proteome, metabolome, on drug discovery, and therapeutics. Biotech researchers, lab administrators, technologists, drug manufacturers, and suppliers can find the latest research news and information related to their fields of endeavor here.
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