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BioResearch

Image: Nanorobotic agents composed of more than 100 million flagellated bacteria - and therefore self-propelled - and loaded with drugs that moved by taking the most direct path between the drug\'s injection point and the area of the body to cure (Photo courtesy of the Montréal Nanorobotics Laboratory, Polytechnique Montréal).

Magnetically Guided Bacteria Transport Drug-Loaded Liposomes to Hypoxic Tumors

A novel transport system for toxic chemotherapeutic drugs is based on a species of bacteria that can be magnetically guided to a tumor where it releases drug-loaded liposomes into the tumor's hypoxic center. More...
24 Aug 2016
Image: A photomicrograph of bone marrow aspirate showing acute myeloid leukemia (AML) (Photo courtesy of Wikimedia Commons).

Phase II Trial Confirms Potential of Venetoclax for Acute Myeloid Leukemia

Results of a Phase II clinical trial indicated that the candidate drug venetoclax was effective for treating patients whose acute myeloid (myelogenous) leukemia (AML) had relapsed or was resistant to chemotherapy. More...
24 Aug 2016

Zika Virus Proteins Linked to Fetal Microcephaly through Activation of Autophagy Pathway

Two Zika virus (ZIKV) proteins have been implicated in causing microcephaly by inhibiting a molecular pathway required for normal fetal brain development. More...
24 Aug 2016
Image: Teneema Kuriakose, Ph.D., a postdoctoral research associate, and Thirumala-Devi Kanneganti, Ph.D. Immunologists have identified the protein trigger in the body’s quick-reaction innate immune system that specifically recognizes the influenza virus in infected cells and triggers their death (Photo courtesy of St. Jude Children’s Research Hospital).

Lung Cell Protein Triggers a Dangerous Immune Response

A protein in the cytoplasm of lung cells helps protect against viral infection, but following invasion by the influenza virus, the same protein stimulates the immune system to overact, which can lead to inflammation or pneumonia. More...
23 Aug 2016
Image: Antibacterial drugs cause changes in the intestinal flora. These changes have an influence on the capacity of the liver and kidneys to detoxify and eliminate therapeutic drugs due to large changes in the metabolizing and transport proteins (Photo courtesy of Dr. Sumio Ohtsuki, Kumamoto University).

Antibiotics-Induced Changes to Gut Bacteria Influence Expression of Drug Side Effects

Antibiotic treatment disrupts the normal bacterial population of the gut resulting in changes in how the body deals with the breakdown and transport of drugs and other metabolites, which may increase the impact of deleterious side effects. More...
23 Aug 2016
Image: A representation of the crystal structure of a CRISPR-associated protein (Photo courtesy of Wikimedia Commons).

Genetic Engineers Use CRISPR/Cas9 to Transform Fibroblasts into Neurons

A team of biomedical engineers used precisely controlled CRISPR/Cas9 gene editing to convert mouse embryonic fibroblasts to functional induced neuronal cells. More...
23 Aug 2016
Image: A kidney stone (yellow) composed of calcium oxalate showing sharp edges (Photo courtesy of Wikimedia Commons).

Hydroxycitrate Potentially More Effective Than Citrate for Kidney Stones

The chemical hydroxycitrate (HCA) was shown in a recent study to be more effective for treating calcium oxalate kidney stones than the commonly used compound potassium citrate. More...
18 Aug 2016
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BioResearch brings the latest research news on the genome, proteome, metabolome, on drug discovery, and therapeutics. Biotech researchers, lab administrators, technologists, drug manufacturers, and suppliers can find the latest research news and information related to their fields of endeavor here.