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Pathology

Image: Immunohistochemistry of PIK3CA mutations in a breast cancer specimen (Photo courtesy of Prof. Sibylle Loibl, MD, PhD).

Blood Test Helps Tailor Treatments for Advanced Breast Cancer

Information gleaned from a liquid biopsy may help predict how individual women with advanced breast cancer will respond to certain therapies as well as reveal genetic mutations that can impact prognosis.   More...
29 Dec 2015
Image: Micrograph from a prostate biopsy showing a prostatic adenocarcinoma, conventional (acinar) type, the most common form of prostate cancer (Photo courtesy of Nephron).

Prostate Cancer Screening Improved by Repeating Abnormal Tests

For more than 20 years, the prostate-specific antigen test has been used to help screen for prostate cancer, but in recent years, some task forces have called for this blood test to be abandoned because it leads to many unnecessary biopsies.  More...
29 Dec 2015
Image: Micrograph of a seminoma, a common germ cell tumor (Photo courtesy of Wikimedia Commons).

PCR-Based Blood Test Diagnoses Rare Childhood Germ Cell Cancer

A team of British researchers has developed a noninvasive, low cost blood test for the diagnosis of rare childhood germ cell cancer.  More...
28 Dec 2015
Image: The minichromosome maintenance complex component 5 (Mcm5)-enzyme-linked immunosorbent assay (ELISA) kit (Photo courtesy of Arquer Diagnostics Ltd.).

Urine Test Helps Diagnose Bladder Cancer

Bladder cancer is the seventh most common type in the UK, with around 10,000 people diagnosed every year and around two-thirds of cases recur within five years, so patients are monitored routinely after treatment.    More...
22 Dec 2015
Image: Confocal micrograph of immunohistochemically stained human glioblastoma (hGBM) cells (Photo courtesy of Olympus).

Cancer Detected by Dynamic Morphology Tracking on Aptamer-Grafted Surfaces

Cell motility is a phenomenon where cells move by protruding and contracting sections of the membrane that is a complex process performed through sophisticated balancing act between internal cytoskeleton structure and the cell membrane proteins.  More...
22 Dec 2015
Image: Immunohistochemistry of estrogen receptor (ER)-positive (brown), in metastatic breast cancer (Photo courtesy of Dr. Steven Halls).

Different Mutations May Predict Different Responses to Chemotherapy

Among patients with estrogen receptor-positive, metastatic breast cancer, those who had a D538G and/or a Y537S mutation in the estrogen receptor 1 gene, as detected in cell-free DNA obtained from patient blood samples, had significantly worse median overall survival.  More...
21 Dec 2015

Advanced Digital Pathology System Enters Service in the United Kingdom

A major British hospital has incorporated an advanced digital pathology system, which is expected to increase diagnostic accuracy as well as streamlining the performance of the pathology department.  More...
20 Dec 2015
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The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.