Pathology

$Image: A histological section showing a obstructed extrahepatic bile duct. It exhibits residual expression of the enzyme called MMP-7 (shown in brown) (Photo courtesy of Cincinnati Children\'s Hospital Medical Center).$

Diagnostic Test Identified for Pediatric Biliary Atresia

Biliary atresia is a rare disease of the liver and bile ducts that occurs in infants. Liver cells produce bile, which helps digest fat and carries waste products from the liver to the intestines. When an infant has biliary atresia, this flow is blocked and bile becomes trapped inside the liver, quickly causing liver damage and eventually liver failure. More...
05 Dec 2017

CSF Analyzed in Lung Cancer with Brain Metastases

The analysis of mutations in cerebrospinal fluid of lung cancer patients with brain metastases has been explored. Tumor tissue from brain metastasis is difficult to obtain and therefore less invasive methods are needed to identify and monitor the presence of known actionable mutations. More...
29 Nov 2017

Blood Test Reduces Interim for Evaluating Cancer Treatment

Although prognosis and treatment of metastatic breast cancer (MBC) have improved over the last years, there is still an unmet clinical need for more precise prognostic and treatment monitoring tools. More...
27 Nov 2017

Low Testosterone Men Less Likely to Have Prostate Cancer

Prostate cancer affects more than 170,000 men each year in the USA, of who almost 30,000 die from the disease. While it is not yet known what causes the condition, a number of risk factors have been identified, such as age, ethnicity, and genetic mutations. More...
24 Nov 2017

Immunoassay Quantifies Cancer Cell Loss During Treatment

The quantification of cell loss in breast cancer during neoadjuvant treatment (NACT) can be assessed by serum thymidine kinase protein concentrations (sTK1). TK1 has a key function in DNA synthesis and repair responsible for maintaining the nucleoid pool balance by salvage and recycle thymidine from extracellular sources. More...
21 Nov 2017

Image: A scanning electron micrograph (SEM) of breast cancer cells (Photo courtesy of SPL).

Blood Test Detects Resistance to BRCA-Targeting Drugs

Resistance to platinum-based chemotherapy or PARP inhibition in germline BRCA1 or BRCA2 mutation carriers may occur through somatic reversion mutations or intragenic deletions that restore BRCA1 or BRCA2 function. More...
14 Nov 2017

$Image: A histopathology of Barrett\'s esophagus, characterized by the presence of specialized columnar epithelium with goblet cells (Photo courtesy of Dr. John R Goldblum, MD).$