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Pathology

Image: A diagram of the DiviTum assay: BrdUTP is incorporated into a solid-phase DNA-strand. Incorporated BrdU is detected using an anti-BrdU monoclonal antibody conjugated to the signal generating enzyme alkaline phosphatase. The level of BrdU incorporated over time is proportional to the level of thymidine kinas activity in the sample (Photo courtesy of Biovica).

Biomarker Assay Evaluates Efficacy of Novel Breast Cancer Drug

Breast cancer is the most common form of cancer among women today, affecting approximately 362,000 individuals in the European Union (EU) and 233,000 in the USA each year. Around 1,600 new cases are diagnosed every day and 136,000 deaths occur annually (EU+USA). More...
03 Mar 2017
Image: Bone marrow aspirate smear from a patient with myelodysplastic syndrome showing two megakaryocytes with hypolobated, rounded nuclei are present (Photo courtesy of International Agency for Research on Cancer).

Genetic Test Predicts Success of Bone-Marrow Transplant

Genetic mutations drive the pathogenesis of the myelodysplastic syndrome (MDS) and are closely associated with clinical phenotype and therefore, genetic mutations may predict clinical outcomes after allogeneic hematopoietic stem-cell transplantation. More...
02 Mar 2017
Image: The Sysmex XN-9000 automated hematology analyzer (Photo courtesy of Sysmex).

Neutrophil-Lymphocyte Ratio Associated with Cancer Patient Survival

There is emerging evidence showing a significant relationship between overall survival (OS) in non-small cell lung cancer (NSCLC) patients and weight change during chemotherapy or chemoradiation. More...
01 Mar 2017
Image: A diagram showing differences that can be observed in cell morphology in normal skin cells versus melanomas (Photo courtesy of Irene Georgakoudi, Tufts University).

Technique Developed to Diagnose Skin Cancer without Biopsy

Researchers have developed a noninvasive method that accurately identified skin cancer by using multiphoton microscopy to quickly detect abnormal clusters of mitochondria in skin cells. More...
28 Feb 2017
Image: A photomicrograph of lymph node tissue from a person with, idiopathic multicentric Castleman disease. Image shows increased number of blood vessels and smaller germinal centers where immune cells mature in the lymph node, which are two of the pathology features needed to make the diagnosis (Photo courtesy of Dr. David Fajgenbaum, University of Pennsylvania).

Diagnostic Criteria for Multicentric Castleman Disease Published

An international panel of experts in pediatric and adult hematopathology, hematology/oncology, rheumatology, immunology, and infectious diseases has established the first set of diagnostic criteria for idiopathic multicentric Castleman disease (iMCD). More...
28 Feb 2017
Image: The Ion personal genome machine (Photo courtesy of Thermo Fisher Scientific).

New Assay Advances Personalized Therapy for Cancer Patients

Precision medicine attempts to direct treatment for a patient based on molecular alterations known to exist in the patient's disease and the treatment of patients with cancer has been at the center of the evolution for precision medicine studies. More...
24 Feb 2017

Genetic Markers Discovered for COPD

Chronic obstructive pulmonary disease (COPD) is a type of obstructive lung disease characterized by long-term poor airflow and the main symptoms include shortness of breath and cough with sputum production and typically COPD worsens over time. More...
23 Feb 2017
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The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.
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