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Pathology

Image: A colorized scanning electron micrograph (SEM) of two lung cancer cells (Photo courtesy of Anne Weston/Cancer Research UK).

Blood Test Could Predict Best Treatment for Lung Cancer

A blood test could predict how well small-cell lung cancer (SCLC) patients will respond to treatment. In most patients with SCLC, a metastatic, aggressive disease, the condition is initially chemosensitive, but then relapses with acquired chemoresistance. More...
09 Dec 2016
Image: p15 expressed in nevi is a key factor mediating BRAF-induced growth arrest. A, p15 expression in a benign intradermal nevus and B, antibody control C, co-immunofluorescence of p15 and Melan-A in a representative intradermal benign nevus. D, nevus melanocytes express p15, whereas non- nevus melanocytes (white arrows) are p15-negative (Photo courtesy of University of Pennsylvania).

Specific Gene Expression Differentiates Moles from Melanoma

Most melanomas are driven by mutations that spur out-of-control cell replication, while nevi which are moles composed of non-cancerous cells at the skin surface, that harbor the same mutations do not grow wildly. More...
08 Dec 2016
Image: The LSM 780 laser scanning confocal microscope (Photo courtesy of Zeiss).

Diagnostic Tool Designed for Familial Mediterranean Fever

A tool has been developed to diagnose Familial Mediterranean Fever (FMF) which is particularly common among populations originating from around Mediterranean Sea and this genetic disease is characterized by inflammation, fever and severe pain. More...
08 Dec 2016
Image: The UniCel DxH 800 Coulter Cellular Analysis System (Photo courtesy of Beckman Coulter).

Lab Tests Discriminate Bacterial from Nonbacterial COPD Exacerbations

The discrimination of bacterial from nonbacterial acute exacerbations of chronic obstructive pulmonary disease (AECOPD) is difficult, causing antibiotics overuse and bacterial resistance. Sputum cultures are of limited use because results take time. More...
08 Dec 2016
Image: A micrograph showing inflammation of the large bowel in a case of inflammatory bowel disease (Photo courtesy of Wikimedia Commons).

Diagnosing IBD by Evaluating Epigenetic Markers in Blood

Epigenetic screening of blood samples has been proposed as a new approach to diagnosing patients with inflammatory bowel diseases (IBD). More...
07 Dec 2016
Image: A micrograph of an ependymoma (Photo courtesy of Wikimedia Commons).

Epigenetic Biomarker Predicts Outcome of Childhood Brain Cancer

Cancer researchers have identified a biomarker that predicts the likely outcome of the childhood brain cancer posterior fossa ependymoma (PF). More...
07 Dec 2016
Image: These estrogen receptor-positive (ER+) breast cancer cells preserved epigenomic determinants that may be prognostic for cancer survival (Photo courtesy of the National Cancer Institute).

Multiple Biopsies Recommended for Personalized Breast Cancer Treatments

Assessment of somatic mutations is becoming increasingly important for the management of cancer patients, but molecular heterogeneity occurs across many tumors. In breast cancer, there is major interest in the use of pre-surgical studies for assessing the biological effect of therapeutic agents. More...
01 Dec 2016
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The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.
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