Pathology

Genetic Test Predicts Success of Bone-Marrow Transplant

Genetic mutations drive the pathogenesis of the myelodysplastic syndrome (MDS) and are closely associated with clinical phenotype and therefore, genetic mutations may predict clinical outcomes after allogeneic hematopoietic stem-cell transplantation. More...
02 Mar 2017

Neutrophil-Lymphocyte Ratio Associated with Cancer Patient Survival

There is emerging evidence showing a significant relationship between overall survival (OS) in non-small cell lung cancer (NSCLC) patients and weight change during chemotherapy or chemoradiation. More...
01 Mar 2017

Image: A diagram showing differences that can be observed in cell morphology in normal skin cells versus melanomas (Photo courtesy of Irene Georgakoudi, Tufts University).

Technique Developed to Diagnose Skin Cancer without Biopsy

Researchers have developed a noninvasive method that accurately identified skin cancer by using multiphoton microscopy to quickly detect abnormal clusters of mitochondria in skin cells. More...
28 Feb 2017

Image: A photomicrograph of lymph node tissue from a person with, idiopathic multicentric Castleman disease. Image shows increased number of blood vessels and smaller germinal centers where immune cells mature in the lymph node, which are two of the pathology features needed to make the diagnosis (Photo courtesy of Dr. David Fajgenbaum, University of Pennsylvania).

Diagnostic Criteria for Multicentric Castleman Disease Published

An international panel of experts in pediatric and adult hematopathology, hematology/oncology, rheumatology, immunology, and infectious diseases has established the first set of diagnostic criteria for idiopathic multicentric Castleman disease (iMCD). More...
28 Feb 2017

Image: The Ion personal genome machine (Photo courtesy of Thermo Fisher Scientific).

New Assay Advances Personalized Therapy for Cancer Patients

Precision medicine attempts to direct treatment for a patient based on molecular alterations known to exist in the patient's disease and the treatment of patients with cancer has been at the center of the evolution for precision medicine studies. More...
24 Feb 2017

Genetic Markers Discovered for COPD

Chronic obstructive pulmonary disease (COPD) is a type of obstructive lung disease characterized by long-term poor airflow and the main symptoms include shortness of breath and cough with sputum production and typically COPD worsens over time. More...
23 Feb 2017

$Image: Escherichia coli bacteria (red), which are abundant in the immunoglobulin-A-coated microbiota of patients with a Crohn\'s disease-associated condition called spondyloarthritis, promote systemic inflammation. The blue circular structures depict the nuclei of cells called epithelial cells (Photo courtesy of Dr. Kenneth Simpson, Cornell University).$