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Pathology

Image: Porphyromonas gingivalis gingipains in the neurons of Alzheimer\'s brain. P. gingivalis gingipains = red, neurons = yellow, astrocytes = green (Photo courtesy of Cortexyme).

Bacterial Pathogen Discovered in Brains of Alzheimer's Patients

Alzheimer’s disease (AD) patients exhibit neuroinflammation consistent with infection, including microglial activation, inflammasome activation, complement activation, and altered cytokine profiles. More...
06 Feb 2019
Image: The EsophaCap is packed into a gelatin capsule that dissolves in a patient’s stomach exposing the sponge, which gently collects cells from the whole surface of the esophagus when withdrawn. Cellular material will be examined using cytological, immunohistochemical and genomic methods (Photo courtesy of Swallow the Sponge).

Simple Inexpensive Test Screens for Esophageal Cancer

Cancer of the esophagus claims more than 400,000 lives around the world each year. With no efficient, reliable method of screening for the disease, by the time symptoms become apparent, it's often too late to save the patient. More...
05 Feb 2019
Image: Blood test for organ transplant monitoring using DNA sequencing (Photo courtesy of National Heart, Lung and Blood Institute).

Blood Test Improves Detection of Severe Transplant Rejection

Lung transplant recipients have the shortest survival rates among patients who get solid organ transplantation of any kind as only about half live past five years. More...
04 Feb 2019
Image: Tumor Mutation Burden by Targeted Next Generation Sequencing Predicts Benefit to Immune Checkpoint Inhibitors for Cancer (Photo courtesy of Rutgers Cancer Institute).

Tumor Mutational Load Predicts Survival Post-Immunotherapy

A survey of thousands of advanced cancers suggests a way to identify those most likely to respond to groundbreaking therapies that unleash an immune response against tumors, but the results highlight how difficult it will be to translate such an approach into a reliable clinical test. More...
31 Jan 2019
Image: Immunocytochemistry using anti- TRA-1-60 antibody (Photo courtesy of Novus Biologicals).

Blood Test Diagnoses Pancreatic Cancer Disease Earlier

Pancreatic cancer is difficult to diagnose because it often does not have obvious early symptoms; as by the time the disease is found, it typically is quite advanced, complicating treatment and leading to poorer outcomes. More...
29 Jan 2019
Image: High magnification micrograph of a renal oncocytoma. The tumor cells (left of the image) are arranged in nests, have slightly enlarged nuclei and have a more eosinophilic (darker pink) cytoplasm than the normal kidney - renal tubules (right of image) (Photo courtesy of Nephron).

Retina Protein Antibodies Used As Kidney Cancer Marker

Renal cell carcinoma (RCC) is the second-most common uronephrological cancer. In the absence of specific symptoms, early diagnosis of RCC is challenging. Monitoring of the aberrant expression of tumor-associated antigens (TAAs) and related autoantibody response is considered as a novel approach of RCC diagnostics. More...
28 Jan 2019
Image: The Affymetrix Genechip 3000 microarray scanner and autoloader fluidics station 450 (Photo courtesy of New-life Scientific).

Molecular Prognostic Biomarker Found for CNS Lymphoma

Primary central nervous system lymphoma (PCNSL), a rare subgroup of diffuse large B-cell lymphoma (DLBCL) arising in the central nervous system (CNS), is an aggressive malignant variant of nodal non-Hodgkin lymphoma (NHL). PCNSLs account for 3% of all primary CNS tumors and 1% of NHLs in adults. More...
24 Jan 2019
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The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.
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