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Pathology

Image: A bronchial tube, cells stained red and blue are part of the bronchial epithelium, or lining. This demonstrates the existence among these cells of a rare cell type (stained blue-green), believed to be a tuft cell. The scientists have discovered a new type of lung cancer with origins in these cells, which overexpress a gene-regulating protein called POU2F3, a potential target for therapy (Photo courtesy of Cold Spring Harbor Laboratory).

New Genre of Small-Cell Lung Cancer Discovered

Small cell lung cancer (SCLC) is widely considered to be a tumor of pulmonary neuroendocrine cells; however, a variant form of this disease has been described that lacks neuroendocrine features. More...
10 Jul 2018
Image: A histopathology of papillary non–muscle-invasive bladder cancer (Photo courtesy of American Urological Association).

Simple Test Could Reduce Treatment of Bladder Cancer

Bladder cancer is relatively common and imposes the highest per patient cost on the healthcare system of the USA than the management of any other cancer type. Most bladder cancers are early-stage tumors known as papillary non-muscle-invasive bladder cancer (NMIBC). More...
09 Jul 2018
Image: The HiSeq 2000 sequencing platform (Photo courtesy of Illumina).

Recurrent Rearrangements Identified in Soft Tissue Tumors

A new genomic and transcriptomic analysis of rare, soft tissue tumors that develop in infants has detected recurrent specific gene rearrangements that may render them responsive to targeted treatment. More...
06 Jul 2018
Image: A tissue-imaging microscope has been developed that can image living tissue in real time and molecular detail, allowing them to monitor tumors and their environments as cancer progresses (Photo courtesy of Professor Stephen Boppart).

Tissue-Imaging Technology Enables Real-Time Diagnostics

A new microscope system can image living tissue in real time and in molecular detail, without any chemicals or dyes. The system is called simultaneous label-free autofluorescence multi-harmonic microscopy (SLAM). More...
04 Jul 2018
Image: Patients diagnosed with pancreatic cancer can develop elevated blood sugar levels up to three years before their cancer diagnosis (Photo courtesy of Mayo Clinic).

Method Identifies Cancer in Early Onset Diabetics

It is unclear how long pancreatic ductal adenocarcinomas (PDACs) are present before diagnosis. Patients with PDAC usually develop hyperglycemia and diabetes before the tumor is identified. More...
04 Jul 2018
Image: The Aperio Scanscope XT whole-slide scanner (Photo courtesy of Leica Microsystems).

Fine-Scale Histologic Features Estimated at Low Magnification

Whole-slide imaging has ushered in a new era of technology that has fostered the use of computational image analysis for diagnostic support and has begun to transfer the act of analyzing a slide to computer monitors. More...
03 Jul 2018
Image: The QDx Vit. D test is designed for the determination of Vitamin D in whole blood. The test delivers a qualitative result from a finger prick sample of 20 µL within 10 minutes (Photo courtesy of DiaSys).

Vitamin D Levels Linked to Colorectal Cancer Risk

Experimental and epidemiological studies suggest a protective role for vitamin D in colorectal carcinogenesis, but evidence is inconclusive. Circulating 25-hydroxyvitamin D (25(OH)D) concentrations that minimize risk are unknown. More...
27 Jun 2018
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The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.
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