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Pathology

Image: The LSM510 META confocal microscope (Photo courtesy of Zeiss).

Technology Developed for Prostate Cancer Diagnosis and Monitoring

Early diagnosis of prostate cancer and evaluation of appropriate treatment options requires development of effective and high-throughput selective capture technology for exosomes that are positive for the expression of enzyme-biomarker, prostate-specific membrane antigen (PSMA). More...
06 Apr 2017
Image: The Easy-nLC 1000 liquid chromatography system (Photo courtesy of Thermo Fisher Scientific).

Phosphoproteins Identified as Biomarkers for Cancer

The state of protein phosphorylation can be a key determinant of cellular physiology such as early stage cancer, but the development of phosphoproteins in biofluids for disease diagnosis remains elusive. More...
05 Apr 2017
Image: The Combur 10 urinalysis test strips (Photo courtesy of Roche).

Early Serum Creatinine Predicts Post-Surgery AKI

Acute Kidney Injury (AKI) is a common and serious complication of cardiac surgery. Mild AKI occurs in nearly one in five patients undergoing cardiac surgery and is associated with a 19-fold increase in short-term mortality. More...
05 Apr 2017
Image: A genetic variant within the gene for protein tyrosine phosphatase receptor-type delta (PTPRD) has been associated to susceptibility to neurofibrillary tangles, which are thought to be more closely related to memory decline than other forms of aging-related brain pathologies (Photo courtesy of Rush University).

Gene Discovered Associated with Aging Brain Pathologies

Investigators have discovered a gene associated with susceptibility to the common Tau form of brain pathology that accumulates in several different conditions, including Alzheimer’s disease, certain forms of dementia, and Parkinsonian syndromes, as well as chronic traumatic encephalopathy that occurs with repeated head injuries. The gene and its product may serve as a marker for loss of brain function with advancing age, and as a potential drug therapy target. More...
04 Apr 2017
Image: A melanoma on a patient\'s skin (Photo courtesy of the National Cancer Institute).

Fine-Tuned Microscopy Offers Breakthrough Resolution of Melanoma

Researchers have refined a classic Raman-based technique and succeeded in imaging the two dominant melanin molecules, which could lead to new understandings and, critically, early detection of melanoma. More...
17 Mar 2017
Image: The pituitary-specific transcription factor PIT-1 plays an essential role in producing growth hormone (GH), thyroid stimulation hormone (TSH), and prolactin (PRL). Researchers have discovered that a thymoma was detected in examined cases of “anti-PIT-1 antibody syndrome”. PIT-1 expression was abnormally increased within the thymoma and this likely evoked the immune tolerance breakdown and hypopituitarism that occurs in patients with this autoimmune disorder (Photo courtesy of Kobe University).

Autoimmune Disease Trigger Associated with Thymoma Tumors

Researchers have discovered that a newly-identified autoimmune endocrine disease – “Anti-PIT-1 antibody syndrome” – that leads to hypopituitarism is likely caused by overexpression of PIT-1 in the thymoma type of tumor originating from the thymic gland. More...
16 Mar 2017
Image: A structural model of amyloid precursor protein (APP) (Photo courtesy of Wikimedia Commons).

Study Identifies Gene Variants Linked to AD in African Americans

In what may have been the first comprehensive screening of rare coding variants in an African American population, researchers identified several rare gene variants linked to the development of early onset Alzheimer's disease (AD). More...
08 Mar 2017
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The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.
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