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Pathology

Image: A diagram of the role of CD69 in atherosclerosis (Photo courtesy of the Spanish National Center for Cardiovascular Research).

CD69 Biomarker Expression Predicts Atherosclerosis Risk

Atherosclerosis is a disease characterized by the accumulation of lipid deposits in the artery wall, but the disease is usually not detected until after it has caused a clinical event such as a myocardial infarction or stroke. More...
22 Jan 2019
Image: The Synergy H1 multi-mode microplate reader (Photo courtesy of BioTek).

Urinary Detection Method Developed for Prostate Cancer

Prostate cancer (PCa) is one of the most common types of malignancy worldwide and is the second leading cause of cancer death among men. This cancer tends to be asymptomatic and slow growing, often with onset in young men, but usually not detected until the age of 40 to 50 years. More...
22 Jan 2019
Image: The APOL1 G1 and G2 risk alleles in 111 global reference populations (Photo courtesy of the Icahn School of Medicine).

Latinos and Hispanics Prone to Kidney Disease Gene Variant

Risk variants in the apolipoprotein A-I (APOL1) gene on chromosome 22, which were first discovered in African Americans, confer a substantially increased risk of kidney disease, early-onset hypertension, and cardiovascular disease, although disease risk is modified by other genetic factors and by environmental factors. More...
21 Jan 2019
Image: A histopathology of squamous cell carcinoma of the esophagus (Photo courtesy of Nephron).

Age-Related Remodeling Linked to Normal Aging

Mutations in some cancer driver genes can arise in seemingly normal esophageal tissue as early as in childhood, becoming increasingly common with age and in response to alcohol or cigarettes. More...
21 Jan 2019
Image: A diagram showing normal and polycystic ovary syndrome, in the latter the ovaries may develop numerous small collections of fluid (follicles) and fail to regularly release eggs (Photo courtesy of Mayo Clinic).

New Risk Loci Identified for Polycystic Ovary Syndrome

Polycystic ovary syndrome is a disorder characterized by hyperandrogenism, ovulatory dysfunction and polycystic ovarian morphology. Affected women frequently have metabolic disturbances including insulin resistance and dysregulation of glucose homeostasis. More...
09 Jan 2019
Image: The FLUOstar Omega is a multi-mode microplate reader and has six detection modes (Photo courtesy of BMG LabTech).

Test Detects Protein Associated with Alzheimer’s and CTE

An ultrasensitive test has been developed that detects a corrupted protein associated with Alzheimer’s disease and chronic traumatic encephalopathy (CTE). This advance could lead to early diagnosis of these conditions and how they originate. More...
09 Jan 2019
Image: The NovaSeq 6000 sequencing system platform (Photo courtesy of Illumina).

Diverse Chronic Kidney Diseases Diagnosed with Exome Sequencing

Exome sequencing is emerging as a first-line diagnostic method in some clinical disciplines, but its usefulness has yet to be examined for most constitutional disorders in adults, including chronic kidney disease, which affects more than 1 in 10 persons globally. More...
08 Jan 2019
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The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.