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Pathology

Image: The Promega MSI Analysis System V1.2 and the LMR-MSI systems are PCR-based methods for detecting microsatellite instability (MSI) in solid tumors (Photo courtesy of Promega)

Long Mononucleotide Repeat Markers Validated for Microsatellite Instability Detection

Mismatch repair deficiency (dMMR) predicts response to immune checkpoint inhibitor therapy in solid tumors. Long mononucleotide repeat (LMR) markers may improve the interpretation of microsatellite instability (MSI) assays. More...
12 Jan 2022
Image: Advanced stage of stomach cancer with stomach tissue array, including pathology grade, malignant tumors (TNM) and clinical stage (Photo courtesy of SuperBioChips Laboratories)

Natural Killer Cell-Associated Markers Investigated in Gastric Cancer

Gastric cancer (GC) is one of the leading causes of cancer-related deaths worldwide. Although the survival rates of GC patients have increased with proper screening systems, standardized surgical protocols, and development of chemotherapy regimens, the general outcome of GC patients, especially those in advanced stages, remains poor. More...
11 Jan 2022
Image: The Immulite 2000 XPI System is an easy to use, continuous random-access immunoassay analyzer with one of the largest automated immunoassay menus available (Photo courtesy of Siemens Healthcare)

Association Between Helicobacter pylori With Nonalcoholic Fatty Liver Disease Assessed

Non-alcoholic fatty liver disease is closely linked to various metabolic disorders such as obesity, type 2 diabetes, and cardiovascular disease, and has been considered as a hepatic manifestation of metabolic syndrome. More...
06 Jan 2022
Image: A) NDUFS1 immunohistochemistry staining of prostate cancer (PCa) tissue microarray (TMA) samples and B) ATP5O immunohistochemistry staining of PCa TMA samples. Staining intensity as per number. Scale bar = 100 µm (Photo courtesy of Medical University of Vienna)

Novel Protein Biomarkers Identified for Prostate Cancer Aggressiveness

Prostate cancer is the most commonly diagnosed cancer in men and is among the top five causes of cancer-related death. In most cases, prostate cancer can be successfully treated but there is a group of patients who suffer an aggressive course and often fatal outcome. More...
05 Jan 2022
Image: Normal or Near Normal Aminotransferase Levels Found in Patients with Alcoholic Cirrhosis (Photo courtesy of Biology Dictionary)

Near Normal Aminotransferase Levels Reported in Alcoholic Cirrhosis Patients

Alcoholic cirrhosis affects around 1 in 400 adults in the USA. It is an advanced form of liver disease, which occurs when chronic ethanol use leads to inflammation and cirrhosis or scarring of the liver. Less than 50% of people diagnosed with advanced liver disease due to cirrhosis survive for one year, and so early diagnosis is crucial. More...
30 Dec 2021
Image: A colored scanning electron micrograph (SEM) of a breast cancer cell (Photo courtesy of Case Western Reserve University School)

Biomarker FR+CTC Explored for Breast Cancer Diagnosis

The prognosis of breast cancer is dramatically improved owing to progress on the early diagnosis and effective therapy, and the survivor number is higher than any other types of cancers. However, the number of new breast cancer cases reached 2.26 million in 2020, accounted for 11.7% of all new tumor cases. More...
30 Dec 2021
Image: Blood film from a patient with Monoclonal B-cell lymphocytosis. The circulating atypical lymphocytes are mature with a small rim of basophilic cytoplasm. Monoclonal population of B cells in the blood is less than 5 ×109/L (Photo courtesy of Elizabeth Courville, MD)

Tissue Counterpart to Monoclonal B-Cell Lymphocytosis Characterized

Monoclonal B-cell lymphocytosis (MBL) was initially proposed to recognize patients with a monotypic B-cell population identified by peripheral blood (PB) flow cytometry (FC) that did not meet numerical criteria for chronic lymphocytic leukemia (CLL). More...
27 Dec 2021
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The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.