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Microbiology

Image: The portable MinION sequencing platform runs one flow cell and desktop GridION can run up to five flow cells at any time (Photo courtesy of Oxford Nanopore).

Metagenomic Sequencing Quickly Identifies Pathogens in Body Fluids

Metagenomic next-generation sequencing (mNGS) is a shotgun sequencing approach in which all of the nucleic acid (DNA and RNA) in a clinical sample is sequenced at a very high depth, 10-20 million sequences per sample. More...
23 Nov 2020
Image: Histological features of COVID-19 lungs (Photo courtesy of the University of Trieste).

COVID-19 Lung Damage Caused by Persistence of Abnormal Cells

Several uncertainties still relate to the involvement of other organs in COVID-19. Besides indirect multi-organ injury, a few reports have suggested the possibility of direct injury caused by viral replication in brain, heart and kidney. More...
19 Nov 2020
Image: The STANDARD F Dengue IgM/IgG FIA qualitatively analyzes Dengue virus specific IgM and IgG antibodies in serum, plasma and whole blood using fluorescent immunoassay (Photo courtesy of SD Biosensor).

Rapid Tests Evaluated in the Management of Dengue Fever

Dengue is a mosquito-borne infection caused by four distinct viruses (DENV 1-4) which belong to the flavivirus genus and may lead to diverse outcomes. The disease can be asymptomatic in about 75% of cases, causing Dengue fever (DF), or result in severe dengue. Dengue is common in more than 120 countries. More...
12 Nov 2020
Image: The iFlash 1800 chemiluminescence immunoassay analyzer (Photo courtesy of Shenzhen YHLO Biotech).

Serum-IgG Responses in Patients with Mild and Severe COVID-19

The coronavirus disease 2019 (COVID-19) pandemic continues, causing considerable morbidity and mortality worldwide. The severity of COVID-19 ranges from asymptomatic to fatal pneumonitis, with mildly symptomatic patients accounting for approximately 80% of all cases according to current understanding. More...
04 Nov 2020
Image: Serological test performed at the rabies laboratory. The Bio-Rad Platelia Rabies II ELISA kit is one of the diagnostic assays that are routinely conducted for the determination of antibodies against the rabies virus (Photo courtesy of Korean Animal and Plant Quarantine Agency).

Antibodies Against Rabies Detected in Human Dried Blood Spots

Rabies is a viral disease that causes inflammation of the brain in humans and other mammals. Early symptoms can include fever and tingling at the site of exposure. Although preventable by vaccination for more than a century, rabies virus still causes numerous fatalities every year. More...
03 Nov 2020
Image: The signal of SMOLT is generated by the displacement of micron-size beads tethered by DNA long-probes that are between 1 and 7 microns long. The molecular extension of thousands of DNA probes is determined with sub-micron precision using a robust, rapid and low-cost optical approach (Photo courtesy of Scanogen).

Single-Molecule Tethering Detects Nucleic Acids and Microorganisms

Detection of microbial nucleic acids in body fluids has become the preferred method for rapid diagnosis of many infectious diseases. However, culture-based diagnostics that are time-consuming remain the gold standard approach in certain cases, such as sepsis. More...
29 Oct 2020
Image: The AFIAS-6 (AFIAS-automated fluorescent immunoassay system) is an automated fluorescent immunoassay system that uses blood, urine, and other samples to measure quantitatively or semi-quantitatively the concentration of targeted analyte (Photo courtesy of Boditech Med Inc).

New Diagnostic Tests for Rotavirus and Norovirus Infections Evaluated

Acute gastroenteritis is one of the most impactful and common infectious diseases, accounting for millions of deaths annually in young children. Rotavirus and norovirus are leading causes of acute viral gastroenteritis spread through fecal to oral transmission. More...
21 Oct 2020
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The LabMedica Microbiology channel provides the latest news in the fields of epidemiology, bacteriology, virology, and parasitology, all viewed from the unique perspective of Laboratory Medicine.