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Immunology

Image: The QX200 droplet digital polymerase chain reaction (ddPCR) instrument (Photo courtesy of Bio-Rad).

Click Chip’ Detects Early-Stage Liver Cancer Biomarkers in Extracellular Vesicles

 Hepatocellular carcinoma (HCC) is the fourth most common cause of cancer-related deaths worldwide. The poor prognosis of HCC can be attributed to the fact that diagnosis is often made at a late stage in disease development. More...
21 Sep 2020
Image: Histology of normal small intestinal mucosa in adequately treated celiac disease (A). Untreated coeliac disease shows the classic triad of infiltration of the epithelium with lymphocytes, crypt hyperplasia and villous atrophy (B) (Photo courtesy of Professor Jason Tye-Din, MBBS PhD).

Unique Antibody Profile Differentiates Gluten Sensitivity from Celiac Disease

Until recently, many doctors often dismissed the complaints of people who claimed to be sensitive to foods containing gluten but did not have celiac disease, a well-documented autoimmune disease triggered by exposure to the dietary protein found in wheat, rye, and barley. More...
17 Sep 2020
Image: Increased MAIT and iNKT cell activation is associated with improved outcome in severe COVID-19 patients (Photo courtesy of the University of Tours).

Unconventional T Cells in COVID-19 Patients Predicts Disease Outcome

While most people infected with the SARS-CoV-2 virus experience relatively mild symptoms, some patients mount an aberrant inflammatory response that can damage the lungs and cause acute respiratory distress syndrome (ARDS), potentially resulting in the patient's death. More...
17 Sep 2020
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New Gold and Copper Nanoshell-Enhanced Immunoblotting Technique Makes POC Diagnosis of Tuberculosis Easier

A team of researchers have developed a straightforward and naked-eye-sensitive nanoshell-enhanced immunoblotting technique to detect Mycobacterium tuberculosis (MTB) antigen 85B (Ag85B). More...
09 Sep 2020
Image: Schematic diagram of the immunoassay based on proximity extension assay (PEA) technology (Photo courtesy of Olink Proteomics).

Six Biomarkers Predict Severity of COVID-19

Coronavirus disease 2019 patients admitted to the ICU have high mortality. The host response to coronavirus disease 2019 has only been partially elucidated, and prognostic biomarkers have not been identified. More...
08 Sep 2020
Image: The RF direct latex tests for the detection of rheumatoid factor (RF) in serum (Photo courtesy of VedaLab).

Specificity of Rheumatoid Factor Detected by Latex Fixation Compared

Rheumatoid arthritis is a chronic inflammatory and autoimmune disorder that can affect more than just the joints. In some people, the condition can damage a wide variety of body systems, including the skin, eyes, lungs, heart and blood vessels. More...
02 Sep 2020
Image: Mass cytometry by time of flight uses CyTOF technology to enable deep profiling of translational and clinical samples across a range of cell surface and intracellular markers (Photo courtesy of University of Virginia).

Adaptive Immune Cells in Ulcerative Colitis Revealed by Single-Cell Analyses

Inflammatory bowel disease encompasses a spectrum of complex intestinal disorders characterized by dysregulated innate and adaptive immune responses to gut microbiota in genetically susceptible hosts. More...
01 Sep 2020
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The Immunology channel of LabMedica deals with diagnostic techniques and immuonassays such as ELISA, pregnancy tests, immunoblotting, immunohistochemical staining, serology, and associated hardware.