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Hematology

Image: Haptoglobin 1 allele predicts higher serum haptoglobin concentration and lower multiorgan failure risk in sickle cell disease (Photo courtesy of Dreamstime)

Haptoglobin 1 Allele Predicts Higher Serum Haptoglobin Concentration in SCD

Approximately 30% of the hemolysis in sickle cell disease (SCD) is intravascular, resulting in increasing plasma cell–free hemoglobin which contributes to organ damage through direct oxidative injury, consumption of nitric oxide, and upregulation of inflammatory pathways. More...
29 Dec 2022
Image: The CellaVision DC-1 is a stand-alone hematology analyzer that performs blood cell differentials. It offers a suitable solution for laboratories with small workloads (Photo courtesy of Sysmex)

Novel Digital Morphology Analyzer Performance Evaluated

Microscopic examination of peripheral blood smear (PBS) is essential in clinical hematology laboratories. Manual counting is, however, inefficient because the process is technically demanding and labor-intensive resulting in long turnaround time (TAT), and the results may be subjective with inter-observer variation. More...
01 Dec 2022
Image: Trichinella sp. found in muscle tissue (Photo courtesy of McGill University)

Laboratory Features of Trichinellosis and Eosinophilia Threshold Determined

Trichinella nativa is a nematode worm, one of the species of the genus Trichinella, found in arctic and subarctic regions. It is highly pathogenic and has a high resistance to freezing. It is encapsulated, and infects a wide variety of mammals and birds. More...
01 Dec 2022
Image: Quantra Hemostasis Analyzer (Photo courtesy of HemoSonics)

Next-Gen POC Whole Blood Hemostasis System Recognizes Specific Needs of EDs and ORs

A next-generation POC hemostasis system leverages innovative medical-grade ultrasound technology to measure the coagulation properties of a whole blood sample. With its rapid results, ease of operation, and dials screen for straightforward interpretation, it is the only whole blood hemostasis testing system specifically cleared for use in POC settings, such as ORs, EDs, and ICUs. More...
01 Dec 2022
Image: The 10X Genomics Chromium Single Cell Gene Expression Solution (Photo courtesy of Technion Israel Institute of Technology)

Immune Microenvironment Characterized in Multiple Myeloma Progression

Multiple myeloma (MM) is a malignant disease of plasma cells (PCs) that reside within the bone marrow (BM). Early alterations within the bone marrow microenvironment that contribute to the progression of MM from its precursor stages could be the key to identifying novel therapeutic approaches. More...
30 Nov 2022
Image: TruSight Lymphoma 40 uses expert-defined content and proven next-generation sequencing (NGS) technology to identify somatic variants associated with lymphomas (Photo courtesy of Illumina)

Tumor Biopsies Analysis Performed on Newly-diagnosed B-cell Neoplasms

Comprehensive genomic analyses of tumor biopsies from patients with newly-diagnosed germinal center B cell (GCB) diffuse large B cell/high grade B cell lymphoma (DLBCL/HGBL) have identified molecular subtypes predictive of inferior survival, which are characterized by somatic mutations that can be detected through clinical laboratory mutation analysis (CLMA). More...
22 Nov 2022
Image: The compact xMAP INTELLIFLEX system is a flow-based, multiplex platform that simplifies the workflow by combining the established performance of xMAP technology (Photo courtesy of Thermo Fisher Scientific)

Assay Developed to Measure Anti-Factor VIII Antibodies

Hemophilia is a mostly inherited genetic disorder that impairs the body's ability to make blood clots, a process needed to stop bleeding. This results in people bleeding for a longer time after an injury, easy bruising, and an increased risk of bleeding inside joints or the brain. More...
21 Nov 2022
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The Hematology channel at LabMedica covers the all aspect of plasma, coagulation, transfusion medicine, and blood banking, as well as related lab tools and techniques.