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Molecular Diagnostics

Image: Liquid Biopsy: Solid tumor masses may shed (1) circulating tumor DNA (ctDNA) and circulating tumor RNA (ctRNA), (2) apoptotic circulating tumor cells (CTCs), or (3) intact CTCs into the circulation. In addition, ctDNA and ctRNA may enter the bloodstream after apoptosis of circulating and non-circulating tumor cells (4) (Photo courtesy of H. McDonald / Science Translational Medicine).

Liquid Biopsy Test Launched for NRAS Mutations

The NRAS gene encodes for the N-Ras protein, which is involved in communicating signals from the exterior of the cell to the cell's interior (called signal transduction). These signals provide instructions for a cell to proliferate or differentiate. More...
20 Sep 2017
Image: The Tumor Mutation Burden test detects cell free tumor DNA in the blood and allows for stratification of patients not eligible to have a tumor biopsy (Photo courtesy of the US National Cancer Institute).

Blood Test Predicts Immunotherapy Efficacy

A test developed with the US-based genetic testing specialist could be significant because, although potent, it is difficult to predict which patients will respond to immunotherapies, which are setting new care standards in some types of tumors. More...
20 Sep 2017
Image: A human malignant melanoma cell viewed through a fluorescent, laser-scanning confocal microscope. Invasive structures involved in metastasis appear as greenish-yellow dots, while actin (green) and vinculin (red) are components of the cell’s cytoskeleton (Photo courtesy of Vira V. Artym, PhD, PMP).

Early Stage Melanoma Identified by Simple Blood Test

Melanoma, also known as malignant melanoma, is a type of cancer that develops from the pigment-containing cells known as melanocytes. Melanomas typically occur in the skin but may rarely occur in the mouth, intestines, or eye. More...
20 Sep 2017
Image: An ATR attachment for infrared spectroscopy. The sample is in the steel containers either side of the pink crystal (Photo courtesy of Wikimedia Commons).

Direct Spectroscopy Used for Diagnosis of Neurodegenerative Disorders

Advanced spectroscopy methods were used to establish a direct diagnostic test for Alzheimer's disease and other types of neurodegenerative disorders. More...
19 Sep 2017
Image: A scanning electron micrograph (SEM) of prostate cancer cells (Photo courtesy of David McCarthy).

Tumor Marker Levels Serve As Indicators of Disease Progression

Measuring serum levels of tumor markers may serve as an early indicator of the progression of established tumors in the face of ongoing treatment. More...
19 Sep 2017
Image: The VITEK 2 COMPACT instrument offers the capacity to help improve therapeutic success and patient outcomes through reliable microbial identification (ID) and antibiotic susceptibility testing (AST) (Photo courtesy of bioMérieux).

Newly Emerged Superbug Discovered

Hypervirulent Klebsiella pneumoniae strains often cause life-threatening community-acquired infections in young and healthy hosts, but are usually sensitive to antibiotics. More...
15 Sep 2017
Image: A photomicrograph showing hypertrophic decidual vasculopathy, a finding seen in gestational hypertension and pre-eclampsia (Photo courtesy of Nephron).

Risk of Preeclampsia Linked to Fetal Genes

Preeclampsia affects around 3% of births in Norway; worldwide, that number is estimated to be about 5%. For the first time, a relationship has been found between fetal genes and the risk of preeclampsia in the mother. More...
15 Sep 2017
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