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Molecular Diagnostics

Image: The automated cobas 4800 platform system (Photo courtesy of Roche).

Automated Extraction of FFPE Tissue for High-Risk HPV Testing

The testing for high-risk human papillomavirus (HR-HPV) in head and neck squamous cell carcinomas is important for both prognostication and clinical management. Several testing platforms are available for HR-HPV; however, effective alternative automated approaches are needed. More...
07 Jul 2016
Image: A photomicrograph of auramine-rhodamine stained Mycobacterium tuberculosis (Photo courtesy of Dr. T.V. Rao, MD).

Lung Pathogens Detected Faster by Molecular-Based Method

The genus Mycobacterium is separated into the pathogenic species Mycobacterium tuberculosis complex (MTB), Mycobacterium leprae, and Mycobacterium ulcerans, and various nontuberculous mycobacteria (NTM). More...
07 Jul 2016
Image: An adult Opisthorchis viverrini or Southeast Asian liver fluke stained with carmine (Photo courtesy of the CDC).

Unsuspected Bacterial Link to Bile Duct Cancer Discovered

Bacteria in the bile duct have been identified as a potential risk factor in the development of bile duct cancer, or Cholangiocarcinoma, a rare but aggressive form of cancer with symptoms that do not present themselves at the early stages. More...
06 Jul 2016
Image: A photomicrograph of a blood smear from a patient with acute myeloid leukemia, with very large, immature myeloblasts with many nucleoli (Photo courtesy of the CDC).

Faulty Genetic Instructions Drive Deadly Leukemia in Adults

Acute myeloid leukemia is one of the most common acute leukemia or blood cancer types in adults, and involves over-production of immature blood cells that then crowd out normal, healthy cells. More...
06 Jul 2016
Image: An MRI scan of a brain lesion (white) in a patient with tuberculosis from the study. The yellow circle indicates the biopsy location (Photo courtesy of Johns Hopkins University).

Brain Infections Diagnosed Using Next-Generation Sequencing

The feasibility of next-generation sequencing (NGS) microbiome approaches in the diagnosis of infectious disorders in brain or spinal cord biopsies in patients with suspected central nervous system (CNS) infections has been investigated. More...
06 Jul 2016

Liquid Biopsy Biomarkers for Aggressive Prostate Cancer Discovered

Using targeted proteomics on noninvasive liquid biopsies, researchers have discovered biomarkers that provide signatures of aggressive (extracapsular) prostate cancer (PC), which could enable diagnosis before treatment and so help many low-risk PC patients avoid surgery. More...
05 Jul 2016
Image: The biosensor chip - consisting of a double stranded DNA probe embedded onto a graphene transistor - electronically detects DNA SNPs (Photo courtesy of the University of California, San Diego).

Biochip Combines Graphene Electronics and DNA Strand Displacement for Detection of Polymorphism Mutations

A team of bioengineers has designed an electronic biochip with potential applications for personalized medicine that can detect DNA mutations caused by single nucleotide polymorphisms (SNPs) in real time. More...
05 Jul 2016
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.