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Molecular Diagnostics

Image: A scanning electron photomicrograph of Candida albicans yeast cells (Photo courtesy of Science Photo Library).

Immune-Related Gene Implicated in Chronic Candida Infection Risk

Candida vaginitis is a frequent clinical diagnosis with up to 8% of women experiencing recurrent vulvovaginal candidiasis (RVVC) globally. RVVC is characterized by at least three episodes per year. More...
26 Jun 2019
Image: The HiSeq 2500 high-throughput sequencing system (Photo courtesy of Illumina).

Clinical Metagenomic Sequencing Improves Diagnosis of Neurological Infections

Metagenomic next-generation sequencing (NGS) is a promising approach for the diagnosis of infectious disease because a comprehensive spectrum of potential causes, viral, bacterial, fungal, and parasitic, can be identified by a single assay. More...
26 Jun 2019
Image: Identifying a metastatic colorectal cancer patient’s Consensus Molecular Subtype (CMS) could help oncologists determine the most effective course of treatment (Photo courtesy of University of Southern California).

Identifying Colorectal Cancer Subtypes Improves Treatment Decisions

Colorectal cancer is the second leading cause of cancer death in the USA, and is expected to cause about 51,000 deaths in 2019, but until now, it was unclear which drugs were most effective for which patients. More...
25 Jun 2019
Image: A colorized electron micrograph showing malaria parasite (right, blue) attaching to a human red blood cell. The inset shows a detail of the attachment point at higher magnification (Photo courtesy of [U.S.]NIAID via Wikimedia Commons).

Blood Drop Assay Designed for Monitoring Antimalarial Drug Resistance

A new method for analyzing DNA directly in a drop of blood was designed for monitoring development of resistance to antimalarial drugs. More...
24 Jun 2019
Protocol summary of Vibrio cholerae DNA harvest from specimens preserved on filter paper cards (Photo courtesy of Wellcome Trust Sanger Institute).

Cholera Diagnosed from Dried Spotted Filter Paper

 Cholera outbreaks can rapidly induce high death tolls by overwhelming the capacity of health facilities, especially in remote areas or areas of civil unrest. Global estimates for cholera annually approximate four million cases worldwide with 95,000 deaths. More...
20 Jun 2019
A histopathology of pancreatic ductal adenocarcinoma, a gland-forming cancer. In this example, the adenocarcinoma has wrapped around a nerve (center of the image) (Photo courtesy of JHM).

Novel Methylated DNA Markers Assay Detects Cancer

 An estimated 56,770 people will be diagnosed with pancreatic cancer in the U.S. in 2019, and more than 45,750 will die from the disease. Pancreatic cancer is the third leading cause of cancer-related deaths in the U.S. and is expected to become the second leading cause by 2020. More...
20 Jun 2019
Representative histologic features of the small intestine. In the normal duodenal biopsy (A), the villi are elongated and the crypts relatively short. This is in contrast to the small intestinal tissue affected by celiac disease (B), which demonstrates marked villus blunting and crypt hyperplasia. (Photo courtesy of Tracy R. Ediger MD, and Ivor D. Hill, MD ChB).

Biomarker Found for Celiac Patients on Gluten-Free Diet

 Celiac disease is a complex condition, routinely treated by means of a strict gluten-free diet (GFD). One of the diagnostic challenges of this disease is that patients need to be consuming gluten so that a correct diagnosis by means of endoscopy can be made. More...
19 Jun 2019
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.