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Molecular Diagnostics

Image: A blood smear from a 68-year-old woman with a 13-year history of polycythemia vera and there are three red blood cell precursors present and slight to moderate anisopoikilocytosis (Photo courtesy of The Armed Forces Institute of Pathology).

Myeloproliferative Neoplasms Fall into Genetic Subgroups

Myeloproliferative neoplasms are a group of chronic blood cancers associated with a risk of bleeding and blood clots, but they can also progress to more advanced disease, including leukemia. More...
31 Oct 2018
Image: Deeplex-MycTB deep sequencing test analyses a wide panel of target genes in the bacteria and can identify resistance to over a dozen antibiotics simultaneously (Photo courtesy of Genoscreen).

Multidrug-Resistant TB Outbreak Undetected by Standard Tests

Rapid diagnosis of Mycobacterium tuberculosis resistant to anti-tuberculosis drugs is essential to prevent further acquisition of drug resistance, high morbidity and mortality, and unabated transmission of resistant strains. More...
31 Oct 2018
Image: The Dade Behring BN100 nephelometer (Photo courtesy of Siemens Healthineers).

Chronic Inflammation Linked to Risk for Alzheimer's Disease

While it has been widely shown that possessing the apolipoprotein E4 (ApoE4) gene is the major genetic risk factor of Alzheimer's disease (AD), not all ApoE4 carriers develop AD. It is likely that a complex interaction of genetic vulnerabilities with environmental risk factors lead to AD and identifying such factors could be beneficial for the prevention of AD. More...
30 Oct 2018
Image: A photomicrograph from a prostate biopsy of prostatic adenocarcinoma, conventional (acinar) type, the most common form of prostate cancer (Photo courtesy of Nephron).

Fatal Prostate Cancer Differentiated from Manageable Cancer

Human prostate cancers display numerous DNA methylation changes compared to normal tissue samples. However, definitive identification of features related to the cells’ malignant status has been compromised by the predominance of cells with luminal features in prostate cancers. More...
29 Oct 2018
Image: The MAGPIX compact multiplexing unit performs up to 50 different tests in a single reaction volume and reads a 96-well-plate in just 60 minutes (Photo courtesy of Luminex).

High-Risk HPV Evaluated for Invasive Cervical Cancer

Cervical cancer is a major cause of morbidity and mortality in women worldwide and the role of high-risk human papillomavirus (hrHPV) in the development of invasive cervical cancer (ICC) is well established. More...
29 Oct 2018
Image: The NanoDrop 2000 Spectrophotometer used to quantify and assess purity of DNA, RNA, and Proteins (Photo courtesy of Thermo Fisher Scientific).

CD MicroRNA Marks Subtypes with Differing Outcomes

Crohn’s disease (CD), one of the primary inflammatory bowel diseases (IBD), is a chronic inflammatory condition of the gastrointestinal tract resulting from an aberrant immune response to the enteric microbiota in a genetically susceptible host. More...
25 Oct 2018
Image: A diagram of electric field–induced release and measurement (EFIRM) platform (Photo courtesy of EZLife Bio).

Novel Technology Enables Detection of Early-Stage Cancer

Non-small-cell lung carcinoma (NSCLC) is often fatal because most cases are not diagnosed until they are so advanced that surgical intervention is no longer possible. To improve outcomes a blood test has been developed to detect lung cancer earlier in the disease. More...
24 Oct 2018
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.
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