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Molecular Diagnostics

Image: A three-dimensional (3D) structure of caffeine (Photo courtesy of Wikimedia Commons).

Caffeine Levels Prove Diagnostic for Early Parkinson's Disease

A team of Japanese researchers demonstrated that serum caffeine and its metabolites were reliable biomarkers for detection of early Parkinson's disease (PD). More...
15 Jan 2018
Image: Peripheral blood film from a newborn with hydrops fetalis; note the hypochromia, anisopoikilocytic changes, and erythroblastosis (Photo courtesy of Boston Medical Center).

Parental Screening Can Prevent Hydrops Fetalis in Fetus

Hydrops fetalis (fetal hydrops) is a serious fetal condition defined as abnormal accumulation of fluid in two or more fetal compartments, including ascites, pleural effusion, pericardial effusion, and skin edema. More...
10 Jan 2018
Image: The Sensititre OptiRead automated fluorometric plate reading system for use with Sensititre microtiter plates in antibiotic susceptibility tests (Photo courtesy of Thermo Fisher Scientific).

Mycobacterium Mutations Associated with Clarithromycin Resistance

Mycobacterium abscessus is a leading cause of respiratory diseases and soft tissue infections and it is naturally resistant to many antibiotics in vitro, which complicates clinical treatment and leads to unsatisfactory results. More...
09 Jan 2018
Image: The High Sensitivity Large Fragment Analysis Kit is used for the automated sizing and quantification of large DNA fragments and smears (Photo courtesy of Advanced Analytical Technologies).

Biomarker Detects Fatal Breast Cancer One Year Earlier

DNA methylation is the addition of a methyl group to DNA, which often affects gene expression. Aberrant DNA methylation is common in human tumors and methylation changes occur very early in breast cancer development. More...
03 Jan 2018
Image: The Abbott m2000 RealTime System is a highly flexible and proven solution featuring a broad menu of in vitro diagnostic assays (Photo courtesy of Abbott Molecular Diagnostics).

Molecular Automation Is Changing Clinical Laboratories

Most mid-career laboratory medicine professionals find it hard not to recall the days when DNA had to be extracted manually and polyacrylamide gels were mixed by hand without also reflecting on how fast things have changed. More...
02 Jan 2018
Image: A scanning electron microscope (SEM) image of the respiratory virus Influenza A H7N9 (Photo courtesy of the CDC).

RNA Analysis of Nasal Swabs Diagnoses Respiratory Virus Infection

A panel of three mRNAs has been shown to be able to predict presence of respiratory virus infection in nasal samples with an accuracy of 97%. More...
01 Jan 2018
Image: By attaching specific aptamer molecules to a DNA backbone, researchers have made it easier to detect rare molecules associated with early disease (Photo courtesy of Dr. Joshua Edel, Imperial College London).

Early Disease Detection Made Easier with Aptamer-Related Blood Test

A novel, highly sensitive blood test for a wide range of serum proteins combines aptamer-DNA capture molecules with nanopore-based single molecule sensing. More...
01 Jan 2018
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