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Molecular Diagnostics

Image: A histopathology of Lewy body inclusion (arrow) in a pigmented neuron of the substantia nigra located in the mid-brain (Photo courtesy of the Cleveland Clinic).

Genetic Profile Identified for Dementia with Lewy Bodies

Dementia with Lewy bodies has a unique genetic profile, distinct from those of Alzheimer's disease or Parkinson's disease, according to the first large-scale genetic study of this common type of dementia. More...
25 Dec 2017
Image: An artist\'s representation of a methylated DNA molecule. The two white spheres represent methyl groups bound to two cytosine nucleotide molecules within the DNA sequence (Photo courtesy of Wikimedia Commons).

DNA Methylation Pattern Predicts Remission in Rare Juvenile Leukemia

A team of pediatric cancer researchers has shown that determination of genomic DNA methylation patterns is predictive of outcome in cases of the rare childhood cancer juvenile myelomonocytic leukemia. More...
25 Dec 2017
Image: Researchers have developed a blood sample detection method for MS (Photo courtesy of the University of Huddersfield).

Researchers Develop Metabolomics Approach for Diagnosing MS

A team of British researchers has developed a metabolomics approach for diagnosing multiple sclerosis (MS) by testing blood samples. More...
25 Dec 2017
Image: Bone marrow biopsy of a patient with multiple myeloma, showing diffuse infiltration by neoplastic plasma cells, which can be recognized by the eccentric nucleus and perinuclear halo (Photo courtesy of Dr. Michael G. Bayerl).

Multiple Myeloma Survival Associated with Enzyme Levels

Multiple myeloma (MM) is the second most common blood cancer in the USA and 30% to 50% of multiple myeloma patients have extra copies of the gene that encodes the enzyme Adenosine Deaminase, RNA Specific (ADAR1). More...
21 Dec 2017
Image: This is a malignant melanoma, the most severe form of skin cancer. Melanomas, which arise from dysplastic nevi tend to be asymmetrical, with poorly defined borders and often with varied coloration (Photo courtesy of Skin Cancer Foundation).

Phenocopies Found in Melanoma-Prone Families

Melanoma, but no other cancers, is more common in the non-carriers in these families compared to the normal population. The phenomenon whereby non-carriers of a specific mutation copy the phenotype (in this case melanoma) from their mutation-carrying relatives is known as phenocopy. More...
19 Dec 2017
Image: The Quantifiler Trio DNA quantification kit (Photo courtesy of Thermo Fisher Scientific).

New Assay Predicts Cancerous Pancreatic Lesions

A new simple molecular test has been developed to detect chromosomal abnormalities, biomarkers known as telomere fusions, in pancreatic tumor specimens and pancreatic cyst fluids. This assay may help predict the presence of high-grade or invasive pancreatic cancers requiring surgical intervention. More...
18 Dec 2017
Image: The NutriPhone is a mobile diagnostics platform for monitoring individual vitamin and micronutrient levels was adapted to work with a rapid point-of-care assay system (Photo courtesy of Cornell University).

Rapid POC Assay Detects Micronutrient Deficiencies

A technology that could transform the way nutritional deficiency testing is done worldwide is based on a novel 15-minute point-of-care assay system that enables determination of vitamin A, iron, and inflammation status. More...
18 Dec 2017
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.
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