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Molecular Diagnostics

Image: p15 expressed in nevi is a key factor mediating BRAF-induced growth arrest. A, p15 expression in a benign intradermal nevus and B, antibody control C, co-immunofluorescence of p15 and Melan-A in a representative intradermal benign nevus. D, nevus melanocytes express p15, whereas non- nevus melanocytes (white arrows) are p15-negative (Photo courtesy of University of Pennsylvania).

Specific Gene Expression Differentiates Moles from Melanoma

Most melanomas are driven by mutations that spur out-of-control cell replication, while nevi which are moles composed of non-cancerous cells at the skin surface, that harbor the same mutations do not grow wildly. More...
08 Dec 2016
Image: The LSM 780 laser scanning confocal microscope (Photo courtesy of Zeiss).

Diagnostic Tool Designed for Familial Mediterranean Fever

A tool has been developed to diagnose Familial Mediterranean Fever (FMF) which is particularly common among populations originating from around Mediterranean Sea and this genetic disease is characterized by inflammation, fever and severe pain. More...
08 Dec 2016
DIASOURCE (A Biovendor Company)
Image: Indirect immunofluorescence on a patient’s intestinal lining shows anti-enterocyte antibodies. Enterocytes are the cells of the intestinal lining (Photo courtesy of the NIH).

Successful Treatment of Enteritis Due to Newly Discovered Gene Mutation

Researchers report successful treatment of an adult patient with severe chronic autoimmune enteritis by using the drug Vedolizumab to target the effect on T-cell function of a mutation identified in the patient’s CTLA-4 gene. Vedolizumab may also help skin cancer patients with enteritis due to therapy with Ipilimumab. More...
07 Dec 2016
Image: These estrogen receptor-positive (ER+) breast cancer cells preserved epigenomic determinants that may be prognostic for cancer survival (Photo courtesy of the National Cancer Institute).

Multiple Biopsies Recommended for Personalized Breast Cancer Treatments

Assessment of somatic mutations is becoming increasingly important for the management of cancer patients, but molecular heterogeneity occurs across many tumors. In breast cancer, there is major interest in the use of pre-surgical studies for assessing the biological effect of therapeutic agents. More...
01 Dec 2016

Genetic Test Significantly Reduces Risk of Cardiovascular Events

A quick, precise genetic test can significantly reduce the risk of cardiovascular events by helping to identify more effective medication for some heart patients. The genetic testing allows physicians to pinpoint the best anti-clotting medication for each patient. More...
30 Nov 2016
Image: The MiSeq desktop sequencer for genome sequencing (Photo courtesy of Illumina).

Novel Urine Test Predicts High-Risk Cervical Cancer

A urine test has been developed for the likely emergence of cervical cancer that is highly accurate compared to other tests based on genetic markers derived directly from cervical tissue. More...
30 Nov 2016
Image: The discovery that carrying titin gene mutations also adversely affects heart function in apparently healthy individuals, suggests that the hearts of such people may be “primed to fail” if they also suffer from a second relevant condition (Photo courtesy of Imperial College London).

Titin Gene Mutation Increases Risk of Heart Failure

Previously thought to affect only patients with dilated cardiomyopathy, researchers have discovered that truncating variants in the gene for the protein titin also adversely affect heart function in healthy individuals, placing them at higher risk under conditions of stress. More...
29 Nov 2016
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.
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