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Molecular Diagnostics

Genetic Study Predicts Stomach Cancer Progression

Although stomach cancer is treatable if detected early, diagnosis often occurs at an advanced stage, resulting in high mortality. Intestinal metaplasia (IM) is a pre-malignant condition of the gastric mucosa associated with increased gastric cancer (GC) risk. More...
17 Jan 2018
Image: Researchers have identified genes that could be precursors to Alzheimer’s disease, which could be targets for new treatments that may delay or prevent the onset of the disease (Photo courtesy of Medical News Today).

Genetic Factors Responsible for Alzheimer's Disease Identified

Several new genes have been identified that are responsible for Alzheimer's disease (AD) including those leading to functional and structural changes in the brain and elevated levels of AD proteins in cerebrospinal fluid (CSF). More...
16 Jan 2018
Image: Acute lymphoblastic leukemia (Photo courtesy of Pathology Outlines).

Tumor Suppressor Gene Variants Identified for Leukemia Patients

Newly identified germline variations in a key tumor suppressor gene predispose individuals to develop leukemia as children and leave them with a 1-in-4 chance of developing a second cancer later. Acute lymphoblastic leukemia is the most common childhood cancer and in most cases, the exact cause is unknown. More...
16 Jan 2018
Image: A three-dimensional (3D) structure of caffeine (Photo courtesy of Wikimedia Commons).

Caffeine Levels Prove Diagnostic for Early Parkinson's Disease

A team of Japanese researchers demonstrated that serum caffeine and its metabolites were reliable biomarkers for detection of early Parkinson's disease (PD). More...
15 Jan 2018
Image: Peripheral blood film from a newborn with hydrops fetalis; note the hypochromia, anisopoikilocytic changes, and erythroblastosis (Photo courtesy of Boston Medical Center).

Parental Screening Can Prevent Hydrops Fetalis in Fetus

Hydrops fetalis (fetal hydrops) is a serious fetal condition defined as abnormal accumulation of fluid in two or more fetal compartments, including ascites, pleural effusion, pericardial effusion, and skin edema. More...
10 Jan 2018
Image: The Sensititre OptiRead automated fluorometric plate reading system for use with Sensititre microtiter plates in antibiotic susceptibility tests (Photo courtesy of Thermo Fisher Scientific).

Mycobacterium Mutations Associated with Clarithromycin Resistance

Mycobacterium abscessus is a leading cause of respiratory diseases and soft tissue infections and it is naturally resistant to many antibiotics in vitro, which complicates clinical treatment and leads to unsatisfactory results. More...
09 Jan 2018
Image: The High Sensitivity Large Fragment Analysis Kit is used for the automated sizing and quantification of large DNA fragments and smears (Photo courtesy of Advanced Analytical Technologies).

Biomarker Detects Fatal Breast Cancer One Year Earlier

DNA methylation is the addition of a methyl group to DNA, which often affects gene expression. Aberrant DNA methylation is common in human tumors and methylation changes occur very early in breast cancer development. More...
03 Jan 2018
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