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Molecular Diagnostics

Image: The CellSearch Platform for identification, isolation, and enumeration of circulating tumor cells (Photo courtesy of Menarini Silicon Biosystems).

Liquid Biopsy Detects Cancer across Multiple Biomarkers

Although biomarker-directed therapy is in its infancy in prostate cancer compared to some other tumor types, there is a great need for predictive biomarker testing, and great interest in noninvasive methods. However, comprehensive analysis of patients' cell-free DNA has been limited to date. More...
06 Dec 2018
Image: Gene recombination in neurons that produces thousands of new gene variants within Alzheimer’s disease brains have been identified (Photo courtesy of Sanford Burnham Prebys Medical Discovery Institute).

DNA Recombination in Brain Linked to Alzheimer's Disease

Alzheimer's disease is a public health crisis. The cause of the disease remains unknown and no meaningful treatment exists. Nearly six million people in the USA are living with Alzheimer's disease, a number projected to reach 14 million by 2060 as the population ages. More...
05 Dec 2018
Image: The NextSeq 550 System delivers the power of high-throughput sequencing with the speed, simplicity, and affordability of a benchtop next-generation sequencing (NGS) system (Photo courtesy of Illumina).

Genes Identified That Predispose People to Chronic Kidney Disease

Chronic kidney disease (CKD) affects 10% to 15% of the population worldwide and is now recognized as the most rapidly increasing contributor to global burden of disease. The costs related to CKD and end-stage renal disease (the terminal manifestation of CKD) are an enormous burden for all healthcare systems around the world. More...
05 Dec 2018
Image: The Kalazar Detect Rapid Test for Visceral Leishmaniasis (VL) is a rapid immunochromatographic strip assay for the qualitative detection of antibodies to L. donovani complex in human serum to aid in the presumptive diagnosis of VL (Photo courtesy of InBios).

LAMP Assay Validated for Visceral Leishmaniasis

Visceral leishmaniasis (VL) is one of the most neglected infectious diseases with an annual incidence of 50,000 to 90,000 new cases worldwide. Cases of VL are characterized by irregular bouts of fever, weight loss, hepatosplenomegaly, hypergammaglobulinemia, pancytopenia and anaemia. More...
03 Dec 2018
Image: An illustration showing detection of a single influenza virion using a solid-state nanopore (Photo courtesy of Osaka University).

Nanopore Method Detects Single Influenza Virus at Single Particle Level

A team of Japanese researchers has introduced a novel sensor concept capable of discriminating various types of influenza virus in a label-free fashion by their distinct particle properties. More...
03 Dec 2018
Image: The nCounter platform provides a simple and cost effective solution for multiplex analysis of up to 800 RNA, DNA, or protein targets from diverse samples (Photo courtesy of NanoString).

Highly Multiplexed Broad Pathogen Assay Detects Infectious Diseases

Identifying the causative agent in an acute febrile illness can be challenging diagnostically, especially when organisms in a particular region have overlapping clinical presentation or when that pathogen’s presence is unexpected. More...
29 Nov 2018
Image: A bone marrow smear of a patient with Acute Myeloid Leukemia; dysplastic changes are noted in both the granulocytic and erythroid lineages (Photo courtesy of Peter Maslak).

Acute Myeloid Leukemia Regulatory Networks Identified

Adult acute myeloid leukemia (AML) is a type of cancer in which the bone marrow makes abnormal myeloblasts (a type of white blood cell), red blood cells, or platelets. AML is a heterogeneous disease caused by a variety of alterations in transcription factors, epigenetic regulators and signaling molecules. More...
28 Nov 2018
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.
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