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Molecular Diagnostics

Image: Photograph of an iris melanoma (Photo courtesy of Wikimedia Commons)

MicroRNA Panel Distinguishes Benign Moles from Melanoma in the Eye

 A blood test based on a panel of six microRNAs (miRNAs) is able to distinguish non-cancerous nevi from malignant melanoma in the eye. More...
27 Nov 2019
Image: Growth characteristics of rough and smooth phenotypes of Mycobacterium abscessus on 7H11 agar cultured at 37 °C: representative single rough (left) and smooth (right) colonies (Photo courtesy of Hannover Medical School)

Mycobacterium Infection Found in Gastric Patients’ Stomachs

 Development of gastric diseases such as gastritis, peptic ulcer and gastric cancer is often associated with several biotic and abiotic factors. Helicobacter pylori infection is such a well-known biotic factor. However, not all H. pylori-infected individuals develop gastric diseases and not all individuals with gastric diseases are infected with H. pylori. More...
26 Nov 2019
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Image: Novel, high-accuracy blood test can screen for multiple cancers (Photo courtesy of European Society for Medical Oncology)

Novel, High-Accuracy Blood Test Can Screen for Multiple Cancers

 A new targeted methylation-based assay has been developed that is able to screen blood samples for more than 20 types of cancer at all stages, including lung cancer, with high accuracy and it also correctly pinpoints the tissue of origin (TOO). More...
26 Nov 2019
Image: Axio Vert.A1 inverted microscope (Photo courtesy of Carl Zeiss)

Crohn's Disease-Associated Bacteria Tolerate Antibiotics

 Crohn's disease is a chronic disease that causes inflammation and irritation in the digestive tract. The disease is characterized by an imbalance in the intestinal microbiome. In particular, adherent-invasive Escherichia coli (AIEC) strains have been implicated in the disease. More...
26 Nov 2019
Image: The Oncotype DX test is a genomic test that analyzes the activity of a group of genes that can affect how a cancer is likely to behave and respond to treatment (Photo courtesy of Michael Jarrett/Genomic Health)

Breast Cancer Recurrence Risk Predicted by Immune-Related Germline Variants

 A single normal cell randomly acquires a series of mutations that allows it to proliferate and to be transformed into a cancer cell (i.e., founding clone), which initiates tumor progression and recurrence. More...
25 Nov 2019
Image: Retinoblastoma is cancer of the eye and cannot be biopsied. Aqueous humor is superior to blood to diagnose retinoblastoma (Photo courtesy of Aravind Eye Hospital).

Aqueous Humor Is Superior to Blood to Diagnose Retinoblastoma

Retinoblastoma is a cancer that forms in the light-detecting cells in the back of the eye. It often appears in children under two years of age and can lead to blindness or eye removal. Most cancers are biopsied and studied so that medical scientists can design targeted treatments. More...
25 Nov 2019
Image: Three-dimensional rendering of various types of white blood cells (Photo courtesy of Wikimedia Commons)

A Potential Point-of-Care Method for the Diagnosis of Sepsis

 As part of the effort to create better methods to detect and treat sepsis, researchers developed a technique that enables measurement of the activation and function of white blood cells. More...
21 Nov 2019
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