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Molecular Diagnostics

Image: The structure of human serum albumin (HSA) complexed with six palmitic acid molecules (Photo courtesy of Wikimedia Commons)

Measurement of Oxidized Serum Albumin for Diagnosis of Diabetic Kidney Disease

A recent paper reported that oxidized (cysteinylated) albumin in serum can be used as an early diagnostic marker for diabetic kidney disease. More...
25 May 2021
Image: Schematic of workflow for urinary DNA jagged end analysis. Urinary DNA was subjected to an end-repair process; JI-U = jagged index–unmethylated (Photo courtesy of The Chinese University of Hong Kong)

Jagged Ends of Urinary Cell-Free DNA Assessed in Bladder Cancer Detection

Bladder cancer is where a growth of abnormal tissue, known as a tumor, develops in the bladder lining. In some cases, the tumor spreads into the bladder muscle. The most common symptom of bladder cancer is blood in the urine, which is usually painless. More...
24 May 2021
Image: Dr. Tza-Huei Wang displays the PROMPT test cartridge for rapid diagnosis of gonorrhea infection (Photo courtesy of Johns Hopkins University)

Rapid, Automated Test Detects Gonorrhea and Determines Antibiotic Susceptibility

An inexpensive, portable diagnostic test that gives results in only 15 minutes is expected to revolutionize detection of sexually transmitted diseases such as gonorrhea. More...
24 May 2021
Image: Diagrammatic representation showing the possible mode of disruption in small nuclear ribonucleoproteins (snRNP) complex formation due to loss of GEMIN5 in L1068P and H913R variants

Loss of Function Mutations in GEMIN5 Causes Neurodevelopmental Disorder

GEMIN5, an RNA-binding protein is essential for assembly of the survival motor neuron (SMN) protein complex and facilitates the formation of small nuclear ribonucleoproteins (snRNPs), the building blocks of spliceosomes. More...
20 May 2021
Image: Crystal structure of IL-6 (Photo courtesy of Wikimedia Commons)

Elevated Cytokine Levels Linked to Future Development of Myocardial Infarction

Elevated levels of the plasma biomarkers interleukin-6 (IL-6) and the IL-6 binary complex have been linked to the increased risk of myocardial infarction (MI) found in smokers and individuals with hypertension. More...
17 May 2021
Image: An assay platform that combines robust, high-efficiency biochemistry at the front-end, with next-generation sequencing, and a machine-learning augmented bioinformatics pipeline provides information that can help advanced cancer patients obtain the right treatment (Photo courtesy of Guardant Health, Inc.)

New Blood Test Promises Biopsy-Free Colon Cancer Diagnosis

A newly developed liquid biopsy test detects persistent circulating tumor DNA (ctDNA) after curative surgery and can identify patients with minimal residual disease (MRD) who will ultimately relapse. More...
11 May 2021
Image: Photograph of the novel capsule-based smell test (Photo courtesy of Queen Mary University of London)

A Novel Capsule-Based Smell Test for Diagnosis of Neurological and Respiratory Diseases

To aid in diagnosing diseases where loss of the sense of smell is a symptom, such as in chronic neurological conditions like Parkinson's and Alzheimer's diseases and in acute respiratory infections such as that caused by COVID-19, a team of researchers at Queen Mary University of London (United Kingdom) developed a novel smell testing kit based on capsules of aromatic oils placed between two strips of single-sided tape. More...
10 May 2021
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.