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Molecular Diagnostics

Image: Lupus Erythematosus (LE) Cells are neutrophils that have engulfed lymphocyte nuclei coated with and denatured by antibody to nucleoprotein and are found in systemic lupus erythematosus (Photo courtesy of Dr. Moustafa Abdou, MB, BCh)

Single-Cell RNA-Seq Reveals Cell Type–Specific Molecular and Genetic Associations to Lupus

Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease with elevated prevalence in women and individuals of Asian, African, and Hispanic ancestry. SLE is a disease in which the immune system attacks its own tissues, causing widespread inflammation and tissue damage in the affected organs. It can affect the joints, skin, brain, lungs, kidneys, and blood vessels. More...
12 Apr 2022
Image: The new reagents are designed for ultra-sensitive high-throughput detection of RNA sequences (Photo courtesy of PCR Biosystems Ltd.)

Lyo-Ready PCR Reagents Make Ultra-Sensitive Diagnostics Development Painless

PCR Biosystems Ltd. (London, UK) has launched the Lyo-Ready Probe 1-Step Kit, a lyophilizable 4x RT-qPCR reagent mix designed for ultra-sensitive high-throughput detection of RNA sequences. The new reagents will bring the exceptional sensitivity of the company’s liquid format 1-step RT-qPCR reagents to a freeze-dryable format. More...
12 Apr 2022
Image: Dengue test shows new hope for low-cost diagnostics (Photo courtesy of University of Reading)

Smartphone-Powered Microfluidic ‘Lab on a Strip’ Dengue Test More Powerful Than LFT Testing

Dengue fever affects an estimated 400 million people each year and dengue is a serious health challenge facing half the global population. Now, new ‘lab on a strip’ technology has shown the capability of smartphone-powered tests for dengue fever. More...
11 Apr 2022
Image: Strands of DNA (Photo courtesy of Garvan Institute of Medical Research)

Single-Cell RNA Sequencing Identifies Mechanisms Underlying Autoimmune Diseases

Two recently published studies were designed to help understand how gene expression patterns are cell-type and context specific and can explain observed variation in immune cell function among individuals. More...
11 Apr 2022
Image: The cobas 4800 HPV test and the cobas HPV test for use on cobas 68/8800 systems are clinically validated and FDA approved (Photo courtesy of Roche Diagnostics)

Cervicovaginal DNA Virome Alterations Associated with Genital Inflammation

Cervical cancer is one of the most common cancers among women. In 2021, more than 600,000 cases and 340,000 deaths were reported worldwide. In addition to infection with the human papillomavirus (HPV), known risk factors for cervical cancer include immunodeficiency, smoking and oral contraceptive use. More...
08 Apr 2022
Image: New screening assay identifies drugs targeting prostate cancer (Photo courtesy of University of Aberdeen)

High-Throughput Screening Assay Identifies Drugs to Treat Resistant Prostate Cancer

Many men with prostate cancer receive hormone treatment, which works by stopping male hormones like testosterone feeding the cancer. The problem is that some cancers become resistant to hormone treatment. Now, a novel high-throughput screening assay has been designed to identify inhibitors of the androgen receptor and could be used to identify new drugs to treat resistant forms of prostate cancer. More...
08 Apr 2022
Image: Three-dimensional crystal structure of Anti-müllerian hormone bound to its receptor, AMHR2 (Photo courtesy of Wikimedia Commons)

Circulating Levels of Anti-Müllerian Hormone Can Identify Premenopausal Women Prior to Significant Bone Density Loss

The level of anti-Müllerian hormone (AMH) in the blood has been linked to menopause-related bone loss and may be used to identify women who are experiencing, or about to experience, bone loss related to their transition into menopause. More...
07 Apr 2022
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.