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Clinical Chemistry

Image: A visualization of glucose variability. Solid line: a given excursion. Dashed line: higher glucose variability due to a higher frequency of oscillation. Dotted line: higher glucose variability due to larger amplitude. Note that the mean and area under the curve are identical in the three situations (Photo courtesy of J. Hans DeVries MD, PhD).

Glycemic Variability Predicts Major Adverse Cardiac Event

Major adverse cardiovascular events (MACE) are a composite endpoint frequently used in cardiovascular studies, comparable to the composite endpoint all-cause mortality. Despite widespread use of the term in clinical trials, the definitions of MACE can differ, which makes comparison of similar studies difficult. More...
19 Mar 2019
Image: The Fecal Immunochemical Test has been shown to detect colorectal cancer up to two years earlier than colonoscopy alone (Photo courtesy of Pinnacle BioLabs).

Fecal Immunochemical Tests Performance Characterized for CRC

Many patients experience fear and anxiety before undergoing colonoscopy, which may result in negative experiences. Some doctors believe that having fecal immunochemical test (FIT) as an option might result in more people getting screened for colon cancer. More...
14 Mar 2019
Image: HbA1c provides a longer-term trend, similar to an average, of how high blood sugar levels have been over a period of time (Photo courtesy of Diabetes.co.uk).

HbA1c Levels May Help Predict CF-Related Diabetes

Cystic fibrosis-related diabetes (CFRD) shares some features with both type 1 and type 2 diabetes. In people with cystic fibrosis (CF), the thick, sticky mucus that is characteristic of the disease causes scarring of the pancreas. More...
14 Mar 2019
Image: The three-dimensional (3D) herringbone nanopatterned microfluidic chip that detects cancer faster (Photo courtesy of the University of Kansas).

Nanopatterned Microfluidic Chip Detects Cancer Markers

The performance of current microfluidic methods for exosome detection is constrained by boundary conditions, as well as fundamental limits to microscale mass transfer and interfacial exosome binding. More...
13 Mar 2019
Image: The pHOx Ultra blood gas analyzer is used for routine blood gas analysis (Photo courtesy of Nova Biomedical).

Analysis Compared for Accurate Pleural Fluid pH Determination

Pleural effusion is the pathological accumulation of pleural fluid resulting from excess fluid production and/or increased transpleural pressure, increased capillary permeability, and impaired lymphatic drainage. More...
12 Mar 2019
Image: Blood samples are loaded into a mass spectrometer to analyze them for signs of metabolic variations that could signal autism spectrum disorder (Photo courtesy of NeuroPointDX).

Blood Test Identifies Amino Acid Metabotypes Associated with Autism

Autism spectrum disorder (ASD) could benefit from new and improved diagnostic methods and the arrival of a newly commercialized blood test, along with other efforts headed toward a similar end goal, and could be nudging the field toward earlier detection and intervention. More...
06 Mar 2019
Image: The API 4000 liquid-chromatography mass spectrometry system (Photo courtesy of SCIEX).

Vitamin D Measured in Human Hair

Vitamin D deficiency has reached epidemic proportions worldwide, with over one billion people estimated to be affected. Deficiency has been linked with bone health, but it could also be a risk factor for depression, cardiovascular disease, inflammation, diabetes and cancer. More...
05 Mar 2019
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The Clinical Chemistry channel updates the reader on tests, techniques, and research in the field - from routine assays to specialized tests on blood, urine, enzymes, lipids, hormones and more.