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Clinical Chemistry

Image: A cancer cell amongst normal cells. A new biomarker, plectin, has been discovered in cancer stem cells that governs cancer survival and spread (Photo courtesy of Laurie Fickman/ University of Houston).

New Biomarker Discovered for Cancer Stem Cells

 Tumors often contain a small subset of drug-resisting, self-renewing, and highly metastatic cells called tumor initiating cells or cancer stem cells (CSCs). These cells can self-renew, divide asymmetrically, and form tumors in isolation. More...
28 Nov 2019
Image: The Hepcidin-25 (bioactive) HS ELISA RUO is a highly sensitive enzyme immunoassay for the quantitative measurement of Hepcidin-25 in serum or plasma. Hepcidin is elevated in Parkinson’s disease patients (Photo courtesy of DRG Instruments)

Uremic Toxins Level Measured in Parkinson’s Disease Patients

 Uremic-retention solutes are the compounds whose concentration in an organism increases with decreasing kidney function. At uremic concentrations, they play a crucial role in the progression of chronic kidney diseases (CKD) and have negative outcomes. More...
27 Nov 2019
Image: The cobas c 513 analyzer is a dedicated high throughput HbA1c analyzer designed to meet efficiency, throughput and accuracy needs for HbA1c laboratory testing (Photo courtesy of Roche Diagnostics)

Next Generation Glycated Hemoglobin Assay Evaluated

 Diabetes mellitus is a pathological condition that affects all age groups worldwide. The percentage of glycated hemoglobin A1C (HbA1C) reflects the mean plasma glucose level over the previous 3 to 4 months for most individuals and can be used to diagnose type 2 diabetes. More...
26 Nov 2019
Image: The Architect clinical chemistry autoanalyzer C16000 (Photo courtesy of Abbott Diagnostics).

Effect of Lipoprotein(A) on the Diagnosis of Familial Hypercholesterolemia

 The recent focus on familial hypercholesterolemia (FH) as a high-risk condition predisposing to premature coronary artery disease (CAD) has led to more widespread screening and diagnosis of the condition. Familial hypercholesterolemia is a genetic disorder. More...
25 Nov 2019
Image: The new ClinSpec Diagnostics’ test can diagnose brain cancer from a blood sample (Photo courtesy of University of Strathclyde).

Chemical Analysis of Blood Samples Diagnoses Brain Tumors

 Brain tumors tend to have ambiguous symptoms, such as headache or memory problems, and a brain scan is currently the only reliable way of diagnosing them. In recent years, the use of infrared (IR) spectroscopy to analyze disease state in biofluids has been largely employed with promising results. More...
21 Nov 2019
Image: The nano-plasmonic exosome (nPLEX) sensor (Photo courtesy of Massachusetts General Hospital).

Novel Nanosensing Technologies Developed for Exosome Detection and Profiling

Exosomes are extracellular vesicles (EVs) that are produced in the endosomal compartment of most eukaryotic cells. Liquid biopsy technologies have been developed to do high-throughput exosome protein profiling and point-of-care (POC) exosome analysis. More...
20 Nov 2019
Image: Photomicrograph of a hematoxylin-eosin-stained human lung tissue specimen, harvested from a pulmonary aspergillosis patient. The histopathologic changes indicate the presence of Aspergillus sp. fungal organisms. Note the branching hyphae amongst the lung tissue (Photo courtesy of the Armed Forces Institute of Pathology).

Routine Blood Parameters Predict Invasive Aspergillosis Prognosis

Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems, e.g. those undergoing bone marrow transplantation. Symptoms include fever, chills, shock, delirium, seizures, and blood clots. More...
19 Nov 2019
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The Clinical Chemistry channel updates the reader on tests, techniques, and research in the field - from routine assays to specialized tests on blood, urine, enzymes, lipids, hormones and more.
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