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Clinical Chemistry

Image: A diagram of the 3D-printed microchip electrophoresis device that can sensitively detect three serum biomarkers of preterm birth (Photo courtesy of Brigham Young University).

3D-Printed Device Detects Biomarkers of Preterm Birth

Preterm birth (PTB), defined as birth before the 37th week of gestation, is the leading complication of pregnancy and it affects about 1 in 10 pregnancies worldwide. Preterm infants can suffer complications such as neurological, respiratory and cardiac problems and, in some cases, even death. More...
06 Jun 2019
Image: Tendinous xanthomas on the hand of a patient with familial hypercholesterolemia (Photo courtesy of ScreenPro FH).

Blood Donations Screened for Familial Hypercholesterolemia

Familial hypercholesterolemia is an autosomal-dominant disorder that often causes premature coronary artery disease. Unfortunately, familial hypercholesterolemia remains largely undiagnosed. More...
06 Jun 2019
Image: The Combur-10 brand of reagent strips for urinalysis can be used for cerebrospinal fluid analysis (Photo courtesy of Roche Diagnostics).

Reagent Strips Test Analyzed for CSF in Neurological Disorders

Cerebrospinal fluid (CSF) examination is often performed in emergency to obtain diagnostic information of various life threatening conditions such as meningitis, subarachnoid hemorrhage, demyelinating diseases or carcinomas. More...
05 Jun 2019
Image: Serum Cyr61 concentrations and diagnostic performance of Cyr61 in participants in the training cohort. A: Levels of serum Cyr61 in healthy controls and RA patients (Photo courtesy of Peking University First Hospital).

Cysteine-Rich 61 Biomarker Reflects RA Disease Activity

Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease that causes progressive articular damage, functional loss, and comorbidity. Until now, the exact pathological processes involved in RA remain incompletely understood. More...
05 Jun 2019
Image: A new study suggests fasting may not be necessary to ensure accurate test results when assessing CVD risk (Photo courtesy of Harvard Medical School).

Lipid Levels from Non-Fasting Patients Deemed Suitable for Assessing CVD Risk

Results published in a recent paper suggested strongly that lipid levels measured in blood samples from non-fasting patients were accurate and predicative of future cardiovascular risk. More...
04 Jun 2019
Image: Bioimpedance spectroscopy (BIS) is better than a tape measure for assessing a woman’s risk for developing lymphedema after breast cancer surgery, according to interim results of a study (Photo courtesy of Vanderbilt University School of Nursing).

Bioimpedance Spectroscopy Preferred for Post-Breast Surgery Lymphedema Risk

Interim results from a study that compared bioimpedance spectroscopy (BIS) to the classical tape measure for assessing a woman’s risk for developing lymphedema after breast cancer surgery strongly suggested that BIS was the preferred method. More...
04 Jun 2019
Image: An instrument used for manufacturing test strips to measure stress biomarkers (Photo courtesy of Andrew Higley, University of Cincinnati).

Novel Stress Biomarker Measurement Method Uses UV Range

A recent paper described a novel label-free method for quantitative detection of human performance “stress” biomarkers in different body fluids that is based on optical absorbance of biomarkers in the ultraviolet (UV) range of the spectrum. More...
04 Jun 2019
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The Clinical Chemistry channel updates the reader on tests, techniques, and research in the field - from routine assays to specialized tests on blood, urine, enzymes, lipids, hormones and more.