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Clinical Chemistry

Image: Representative negative-stained transmission electron microscopy images of 4R RT-QuIC products seeded with brain homogenates from individuals with the designated diseases – frontotemporal dementia and Parkinsonism linked to chromosome 17; corticobasal degeneration; and progressive supranuclear palsy (Photo courtesy of National Institute of Allergy and Infectious Diseases).

CSF Test Developed for Uncommon Brain Diseases

Scientific studies have linked the abnormal deposition of tau in the brain to at least 25 different neurodegenerative diseases. However, to accurately diagnose these diseases, brain tissue often must be analyzed after the patient has died. More...
30 Oct 2019
Image: A diagram of the SomaScan Assay that relies on the distinctive properties of Slow Off-rate Modified Aptamer (SOMAmer) reagents, which are proprietary protein binding reagents (Photo courtesy of Somalogic).

Blood Based Biomarkers Characterize Parkinson’s Disease

Parkinson’s disease (PD) is characterized by progressive loss of dopaminergic neurons in the substantia nigra, resulting in a clinical syndrome defined by bradykinesia, rigidity, tremor, and postural instability. More...
29 Oct 2019
Image: The Synergy HTX multi-mode microplate reader is a compact, affordable system for 6- to 384-well microplates and Take3 Micro-Volume Plates (Photo courtesy of BioTek).

Fluorimetric Assay Quantifies Galactocerebrosidase Activity in Dried Blood Spots

The lysosomal enzyme galactocerebrosidase hydrolyzes glycosidic bonds of several glycosphingolipids, including galactose from galactosylsphingosine (psychosine), and is essential to prevent the toxic accumulation of psychosine in the body. More...
29 Oct 2019
Image: The Lumipulse G600 II is a fully automated benchtop chemiluminescent enzyme immunoassay analyzer (Photo courtesy of Fujirebio Europe).

Fibroblast Growth Factor 23 Associated with Diabetic CV Risks

There is an association between higher levels of fibroblast growth factor 23 (FGF23), and greater cardiovascular and mortality risks for adults with type 2 diabetes and normal or mildly impaired kidney function. More...
26 Oct 2019
Image: A microscope image of thyroid cancer cells, specifically papillary thyroid carcinoma, or PTC (Photo courtesy of Wendong Yu/Baylor College of Medicine).

Metabolic Classification of Thyroid Nodules Uses MS Imaging

Fine-needle aspiration (FNA) biopsy is a well-established technique for diagnosis of suspicious thyroid lesions. However, histologic discrimination between malignant and benign thyroid nodules from FNA can be challenging. More...
26 Oct 2019
Image: The VACUETTE Venous K2EDTA blood collection tubes were found the most suitable for the pre-analytical conditions for serotonin assays (Photo courtesy of Greiner Bio-One).

Pre-Analytical Protocols Compared for Serotonin Quantification

Serotonin (5-hydroxytryptamine) is an important neurotransmitter and neuromodulator, which affects many neurophysiological processes, mood and cognition, regulates motility and sensibility in the bowel, and has an essential role in regulating blood pressure. More...
24 Oct 2019
Image: The PATHFAST compact benchtop automatic immunoassay analyzer (Photo courtesy of LSI Medience).

Presepsin Concentrations Correlate with Kidney Function Decline

Sepsis is an important public health problem with more than 750,000 patients reported yearly in the USA with similar figures in Europe. Sepsis continues to be a challenge for practitioners, as sepsis mortality rates are still high despite new antimicrobial and resuscitation agents. More...
24 Oct 2019
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The Clinical Chemistry channel updates the reader on tests, techniques, and research in the field - from routine assays to specialized tests on blood, urine, enzymes, lipids, hormones and more.