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Clinical Chemistry

Image: The Clusterin Human ELISA kit (Photo courtesy of Invitrogen).

Blood Biomarkers Help Diagnose Parkinson's Disease

The identification of circulating biomarkers that closely correlate with Parkinson’s disease (PD) has failed several times in the past. A conventional pipeline for biomarker discovery usually contemplates the collection of clinical samples, such as blood, and their analysis by mass spectrometry. More...
05 May 2020
Image: The Vertex 70 Attenuated Total Reflectance Fourier Transform Infrared (ATR-FTIR) spectrophotometer (Photo courtesy of the University of Guelph).

Salivary Molecular Spectroscopy Used to Monitor Diabetes

Diabetes mellitus (DM) is a metabolic disorder characterized by hyperglycemia which results from insufficient secretion and/or reduced insulin action in peripheral tissues. Frequent monitoring of diabetes is essential for improved glucose control and to delay clinical complications related with diabetes. More...
28 Apr 2020
Image: Histology of multinucleated giant cells engulfing calcium oxalate crystals from a patient with type 1 primary hyperoxaluria (Photo courtesy of Jonathan E. Zuckerman, MD, PhD).

Biomarker Panel Evaluated for Primary Hyperoxaluria Patients

Primary hyperoxaluria (PH) is a group of autosomal recessive disorders characterized by recurrent urinary stones and nephrocalcinosis. Roughly half of PH patients present with advanced chronic kidney disease (CKD) at the time of diagnosis. More...
27 Apr 2020
Image: The Vanquish Flex Ultra High Performance Liquid Chromatography (UHPLC) Systems (Photo courtesy of Thermo Fisher Scientific).

HPLC Method Developed for Vitamin B6 Quantitation

Symptoms of vitamin B6 deficiency can include dermatitis, glossitis, depression, confusion, convulsions, and anemia. Inborn errors affecting vitamin B6 metabolism have been associated with vitamin B6-dependent epilepsy. More...
21 Apr 2020
Image: Higher vitamin B12 level at Parkinson`s disease diagnosis is associated with lower risk of future dementia (Photo courtesy of Jayne Leonard)

Elevated Vitamin-B12 Level Lowers Risk of Parkinson’s Disease Dementia

Previous studies found that, among people with Parkinson’s, those with cognitive impairment, such as dementia, had significantly lower levels of vitamin B12 in their blood. This suggests the possibility that low vitamin B12 or cobalamin levels predispose certain individuals to dementia. More...
15 Apr 2020
Image: The HISCL-5000 is a fully automated immunoassay analyzer with a throughput of 200 tests per hour (Photo courtesy of Sysmex).

Novel Glycoprotein Biomarker Evaluated for Liver Fibrosis

The main pathological consequence of chronic liver diseases is the continuous deposition of collagen fibers, which causes progressive liver fibrosis, and eventually cirrhosis. Mild‐to‐moderate fibrosis is rarely diagnosed because the disease is asymptomatic in the early stage. More...
13 Apr 2020
Image: Early serial measurements of C-reactive protein predicts the outcome in patients with subarachnoid hemorrhage (Photo courtesy of Blue Horizon).

C-Reactive Protein Predicts Neurological Outcomes of Subarachnoid Hemorrhage Patients

Subarachnoid hemorrhage (SAH) is a disease associated with high mortality. Survivors of SAH may manifest severe neurological deficits. In patients with SAH, early brain injury or delayed cerebral ischemia (DCI) is associated with poor outcomes. More...
07 Apr 2020
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The Clinical Chemistry channel updates the reader on tests, techniques, and research in the field - from routine assays to specialized tests on blood, urine, enzymes, lipids, hormones and more.
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