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Clinical Chemistry

Image: A blood film with a normal mature lymphocyte with a single large nucleus is seen on the left, compared to two segmented neutrophils on the right with multiple nuclear lobes. The lymphocytes are decreased in comorbid diabetes and COVID-19 patients (Photo courtesy of Ed Reschke).

Lymphocyte Count Correlated to Comorbid Diabetes and COVID-19

The coronavirus disease (COVID-19) that erupted in China since December 2019 and has gradually spread throughout the world. At present, it has caused tens of thousands of deaths, and the efficacy of certain antiviral drugs is still under review. More...
03 Sep 2020
Image: iCHROMA is an automatic or semiautomatic in-vitro diagnostic device that measures via cartridges the concentration of analytes, contained in blood, urine, or other samples, in quantitative or semi-quantitative ways (Photo courtesy of Boditech Med Inc).

Biomarkers Evaluated for Severity of Diabetic Kidney Disease

Type 2 diabetic mellitus (T2DM) is a chronic metabolic disorder with multiple complications, including diabetic retinopathy, diabetic neuropathy, diabetic kidney disease (DKD) as well as cardiovascular diseases. T2DM is related to an exacerbated systematic inflammation. More...
24 Aug 2020
The TriVersa NanoMate LESA uses chip-based electrospray ionization technology that combines the benefits of liquid chromatography, mass spectrometry, chip-based infusion, fraction collection, and direct surface analysis into one integrated ion source platform (Photo courtesy of Advion BioSciences).

Nanoparticle System Captures Heart-Disease Biomarker From Blood

Physicians currently use an antibody-based test called enzyme-linked immunosorbent assay (ELISA) to help diagnose heart attacks based on elevated levels of cardiac troponin I (cTnI) in the patient's blood sample. While the ELISA test is sensitive, patients can have high levels of cTnI in the blood without having heart disease, which can lead to expensive and unnecessary treatments for patients. More...
20 Aug 2020
By measuring glycated hemoglobin (HbA1c), clinicians are able to get an overall picture of what the average blood sugar levels have been over a period of weeks/months (Photo courtesy of Diabetes.co.uk).

High Blood Glucose Tied to Cardiovascular Risk in Diabetes

 Glycated hemoglobin (HbA1c) is a measure of an overall picture of what the average blood sugar levels have been over a period of weeks/months. If the blood sugar levels have been high over recent weeks, the hemoglobinA1c test will be higher. More...
14 Aug 2020
Typical GC-IMS output of a vaginal swab. Red spots indicate individual chemicals and machine learning identifies which of these chemicals hold discriminatory information (Photo courtesy of the University of Warwick).

New Technique Predicts Preterm Births in High Risk Women

Globally, preterm birth is the leading cause of death in children under 5 years with 15 million babies being born before 37 weeks’ gestation each year. Spontaneous preterm birth is a syndrome, which can be precipitated by a variety of factors. More...
14 Aug 2020
The AB MDS SCIEX API4000 tandem mass spectrometer (Photo courtesy of SCIEX).

Dolichol Biomarker Evaluated for Congenital Disorders of Glycosylation

A congenital disorder of glycosylation (CDG; previously called carbohydrate-deficient glycoprotein syndrome) is one of several rare inborn errors of metabolism in which glycosylation of a variety of tissue proteins and/or lipids is deficient or defective. More...
14 Aug 2020
Image: The Xevo mass spectrometer with an Acquity ultra high performance chromatography system (Photo courtesy of Waters Corporation).

Simple Urine Test Significantly Improves Detection of Adrenal Cancer

Prognosis for patients discovered to have an adrenal cortical carcinoma (ACC), a cancerous adrenal mass, is poor, and a cure is only achievable through early detection and surgery. The incidental discovery of an adrenal mass often triggers additional scans to determine whether the mass is cancerous. More...
06 Aug 2020
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The Clinical Chemistry channel updates the reader on tests, techniques, and research in the field - from routine assays to specialized tests on blood, urine, enzymes, lipids, hormones and more.
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