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Clinical Chemistry

Image: The Luminex MAGPIX Instrument System (Photo courtesy of Thermo Fisher Scientific).

Single-Tube Multimarker Assay Estimates Preeclampsia Risk

The challenge in the clinical practice of pregnancy monitoring is to distinguish isolated gestational hypertension or proteinuria from the development of preeclampsia (PE) with potential severe consequences to the mother and unborn child. More...
03 Dec 2020
Image: The ABL800 FLEX blood gas analyzer measures a full panel of up to 18 STAT parameters on the same blood sample (Photo courtesy of Radiometer).

Spot Urine Sample Evaluated for Renal Potassium Loss

Hypokalemia is characterized by low serum potassium concentrations. Severe hypokalemia can be life threatening, and immediate potassium replacement is often required to prevent sudden cardiac arrest. More...
02 Dec 2020
Image: An ELISA kit for measuring gastric inhibitory polypeptide (GIP) (Glucose-dependent insulinotropic polypeptide) (Incretin hormone) in human sera (Photo courtesy of RayBiotech Life).

Incretin Hormone Levels Linked to Arteriosclerosis

While existing evidence supports beneficial cardiovascular effects of glucagon-like peptide 1 (GLP-1), emerging studies suggest that glucose-dependent insulinotropic peptide (GIP) and/or signaling via the GIP receptor may have untoward cardiovascular effects. More...
30 Nov 2020
Image: An increase in Plasma P-tau217 may be considered as an early Alzheimer disease biomarker (Photo courtesy of Harvard Medical School).

Biomarker Detects Early Alzheimer’s Disease

In Alzheimer disease (AD), abnormal metabolism of amyloid-β (Aβ) and tau leads to accumulation of extracellular plaques formed by misfolded Aβ and intraneuronal neurofibrillary tangles containing phosphorylated tau (P-tau) protein. More...
24 Nov 2020
Image: Elevated fructosamine levels were associated with increased periprosthetic joint infection risk (Photo courtesy of Kristine Houck, MA).

Elevated Fructosamine Levels Associated with Increased PJI Risk

Periprosthetic joint infection (PJI) is the most serious complication that lowers the quality of patients’ life by elevating the patients’ burden of cost and affecting the outcome of total joint arthroplasty. More...
24 Nov 2020
Image: The QTRAP 6500+ Liquid Chromatography with tandem mass spectrometry system (Photo courtesy of Sciex).

Biomarkers Predict Whether RA Patients Will Respond to DMARDs

Rheumatoid arthritis (RA) is characterized by unremitting joint inflammation that results in bone and cartilage destruction and a decreased quality of life. RA may arise from a decreased ability of the host immune response to engage resolution programmes that prevent the precipitation of acute inflammation into chronicity. More...
19 Nov 2020
Image: The Ammonia Breath test: the sensing system included a desiccation cylinder, an airtight sensing chamber, a rotameter, a pump, and an electrical signal measurement instrument (Photo courtesy of Chang Gung University).

Breath Ammonia Biomarker Predicts Kidney Function in CKD Patients

Chronic kidney disease (CKD) is a type of kidney disease in which there is gradual loss of kidney function over a period of months to years. Initially there are generally no symptoms; later, symptoms may include leg swelling, feeling tired, vomiting, loss of appetite, and confusion. More...
18 Nov 2020
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The Clinical Chemistry channel updates the reader on tests, techniques, and research in the field - from routine assays to specialized tests on blood, urine, enzymes, lipids, hormones and more.
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