Clinical Chemistry

ANGPTL8 Levels Associated with Hyperlipidemia in Primary Nephrotic Syndrome
The typical clinical manifestations of Primary Nephrotic Syndrome (PNS) include massive proteinuria, hypoproteinemia, edema and/or hyperlipidemia. Of these, marked proteinuria is the core clinical manifestation, and its severity often parallels the degree of hyperlipidemia. More...28 Apr 2021
Altered Perivascular Fibroblast Activity Precedes ALS Disease Onset
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease of the motor neurons that eventually causes muscular atrophy, paralysis and death. There is currently no cure. The cause of ALS is only understood in the 5% to 10% of patients who have an inherited form of the disease. More...28 Apr 2021

Blood-Based Markers Tied to Brain Cell and Memory Loss
Previous studies have linked elevated levels of plasma total tau and neurofilament light chain (NfL) with worse cognition and neuroimaging measures of cortical thickness, cortical atrophy, white matter hyperintensity, or white matter integrity. More...27 Apr 2021

Serum α-L-Fucosidase Activity Measured for COVID-19 Infection
An unusual fucosylated LacdiNAc in the receptor-binding domains of the spike protein of COVID-19 has been observed. Reduced fucosylation was also found in a specific Fc domain of IgG antibodies in COVID-19 patients that enhanced the interactions with the activating FcγR, FcγRIIIa. More...22 Apr 2021

Urinary Heat Shock Protein 70 Evaluated in Chronic Prostatitis
Chronic prostatitis (CP) is a common, but a confusing urological disease that seriously affects men's lives and health and cannot be ignored. The incidence rate is increasing, and the disease is affecting younger men and long‐term prostatitis affects male sexual function. More...21 Apr 2021

Breath Test Determines Severity of Methylmalonic Acidemia Disease
Methylmalonic acidemia is a disorder in which the body cannot break down certain proteins and fats. The result is a buildup of a substance called methylmalonic acid in the blood. This condition is passed down through families and is one of several conditions called an "inborn error of metabolism." More...20 Apr 2021

Vitamin D Deficiency Linked to Metabolic Changes in Lupus Patients
Systemic lupus erythematosus (SLE), is the most common type of lupus. SLE is an autoimmune disease in which the immune system attacks its own tissues, causing widespread inflammation and tissue damage in the affected organs. It can affect the joints, skin, brain, lungs, kidneys, and blood vessels. More...15 Apr 2021
In Other News
Circulating Calprotectin as Biomarker in Neutrophil-Related Inflammation
Coagulation Dysfunction and Infection Evaluated in Patients with AECOPD
High Liver Enzymes Increase Diabetes Risk for Hispanic Adults
Performance of Five Lipoprotein(a) Immunoassays Evaluated
Flow-Cytometric Expression of Endoglin Assessed in B-Acute Lymphoblastic Leukemia
NMR-Based Method Measures Circulating Blood Citrate Levels
Vitamin D Levels Tied to COVID-19 Risk for African-Americans
White Blood Cell Help Define Pediatric Urinary Tract Infections
Calcitonin and Procalcitonin Immunoassays Investigated for Medullary Thyroid Carcinoma
Chemiluminescence Anti‐Müllerian Hormone Assay Performance Characterized
Cardiac Troponins Assessed for Acute Heart Failure
CSF Biomarker Flags Parkinson's Pathology Much Earlier
Blood Biomarker Discovered for Autism Spectrum Disorder
Biomarker Protein Investigated in Juvenile Idiopathic Arthritis
Immune Response to Insulin Identifies Risk of Juvenile-Diabetes
Fibrinogen to Albumin Ratio Reflects ANCA‐Associated Vasculitis Activity
Three Automated Urine Analyzers Compared with Manual Microscopic Urinalysis
Stabilized Urinary Biogenic Amines Measured in Clinical Chemistry Laboratories
Biomarkers Evaluate Kidney Injury in Cancer Patients
Blood Test Distinguishes Epileptic Seizures From PNES
Abnormal Liver Function Test Associated with Severe SARS-CoV-2 Infection
New Control Mechanism Discovered in Innate Immune System
Reference Intervals for Liver Function Tests Established for Minors
The Clinical Chemistry channel updates the reader on tests, techniques, and research in the field - from routine assays to specialized tests on blood, urine, enzymes, lipids, hormones and more.







