We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

LabMedica

Download Mobile App
Recent News Expo Clinical Chem. Molecular Diagnostics Hematology Immunology Microbiology Pathology Technology Industry Focus

High-Sensitivity C-Reactive Protein Investigated in Acute Myocardial Infarction Patients

By LabMedica International staff writers
Posted on 12 Nov 2020
Type 2 diabetes mellitus (DM) is a common comorbidity in acute myocardial infarction (AMI), and it is associated with two-fold higher in-hospital and long-term mortality rates and with a higher risk of recurrent cardiovascular events.

C-reactive protein (CRP), an acute phase protein secreted by the liver, is the most widely used biomarker for detecting inflammatory conditions. To assess cardiovascular risk, physicians have now adopted high-sensitivity CRP (hs-CRP), instead of standard CRP assays that monitor infections and other inflammatory conditions.

Image: The cobas c 501 module for clinical chemistry (Photo courtesy of Roche Diagnostics).
Image: The cobas c 501 module for clinical chemistry (Photo courtesy of Roche Diagnostics).

Cardiologists at the Monzino Cardiological Center Institute (Milan, Italy) carried out a prospective, observational study and enrolled 2,178 patients with AMI between June 1, 2012 and October 1, 2017. Patients were considered as suffering from DM if one of the following conditions were present: personal history of DM reported in clinical record, treatment with glucose lowering drugs, or a glycated hemoglobin value ≥ 6.5% (48 mmol/mol). High-sensitivity-CRP was measured at hospital admission by Cobas assay (particle-enhanced immunoturbidimetric assay) on Cobas c501 (Roche Diagnostics, Risch-Rotkreuz, Switzerland). A hs-CRP value ≥ 2 mg/L was considered a sign of inflammation.

The scientists reported that 548 (26%) patients had DM and they had higher hs-CRP levels than non-DM patients (5.32 versus 3.24 mg/L)). The primary endpoint incidence in the overall population (7%, 9%, 13%, 22%), in DM (14%, 9%, 21%, 27%), and non-DM (5%, 8%, 10%, 19%) patients increased in parallel with hs-CRP quartiles. The adjusted risk of the primary endpoint increased in parallel with hs-CRP quartiles in DM and non-DM patients, but this relationship was less evident in DM patients.

In the overall population, the adjusted odds ratio (OR) of the primary endpoint associated with an hs-CRP value ≥ 2 mg/L was 2.10. For the same risk, hs-CRP was 7 mg/L and 2 mg/L in patients with and without DM. A similar behavior was observed for the secondary endpoint when the hazard ratio (HR) associated with an hs-CRP value ≥ 2 mg/L found in the overall population was 2.25. For the same risk, hs-CRP was 8 mg/L and 1.5 mg/L in DM and non-DM patients.

The authors concluded that hs-CRP predicts in-hospital outcome and two-year mortality in AMI patients with and without DM. However, in DM patients, the same risk of developing events as in non-DM patients is associated to higher hs-CRP levels. The study was published on October 20, 2020 in the journal Cardiovascular Diabetology.



Platinum Member
COVID-19 Rapid Test
OSOM COVID-19 Antigen Rapid Test
One Step HbA1c Measuring System
GREENCARE A1c
Anti-Cyclic Citrullinated Peptide Test
GPP-100 Anti-CCP Kit
New
Gold Member
TORCH Panel Rapid Test
Rapid TORCH Panel Test

Latest Clinical Chem. News

POC Biomedical Test Spins Water Droplet Using Sound Waves for Cancer Detection

Highly Reliable Cell-Based Assay Enables Accurate Diagnosis of Endocrine Diseases

New Blood Testing Method Detects Potent Opioids in Under Three Minutes