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BioResearch

Image: A strong immune response can be seen in this immunofluorescence image of lung tissue infected with pneumonia where immune cells are stained green and red (Photo courtesy of Colin Buss, Massachusetts Institute of Technology).

Nanoparticle Assay Detects Respiratory Bacteria in Pneumonia Model

Researchers used a mouse pneumonia model to demonstrate how a nanoparticle-based technique could be used to detect Pseudomonas aeruginosa bacteria in infected animals and monitor bacterial clearance from their lungs during the course of antibiotic treatment. More...
13 Dec 2018
Image: Six days after treatment with IGF-1 carried by dendrimer nanoparticles (blue), the particles have penetrated through the cartilage of the knee joint (Photo courtesy of Brett Geiger and Jeff Wyckoff, Massachusetts Institute of Technology).

Deeply Penetrating Nanoparticles Designed to Treat Osteoarthritis

A novel nanoparticle-based drug transport system designed to treat osteoarthritis delivers the anabolic growth factor IGF-1 (insulin-like growth factor 1) directly to injured chondrocytes, which are located deep within a dense layer of cartilage tissue. More...
12 Dec 2018
Image: Endodermal cells, they form organs such as lung, liver and pancreas (Photo courtesy of IDR, Helmholtz Zentrum München).

Diabetes Researchers Convert Stem Cells into Insulin-Producing Cells

A team of stem cell biologists working on the problem of pancreas replacement in patients with type I diabetes identified the extrinsic and intrinsic signaling mechanisms that coordinate the fate-determining transcriptional events underlying the maturation of bipotent pancreatic progenitors and used this information to convert these pancreatic progenitors - derived from human embryonic stem cells - to insulin-producing islet cells. More...
11 Dec 2018
Image: Illustration showing the protein Cas12a (Cpf1) bound to a DNA helix (red and white) (Photo courtesy of T. Yamano and H. Nishimasu, who discovered and published the coordinates of each atom in the protein-DNA complex. James Rybarski used those coordinates and software called PyMol to generate the illustration).

Analytical Tools Reveal Molecular Mechanism of Gene-Editing Tool

A recent paper described the use of advanced analytical techniques to define the mode of action of the gene-editing tool CRISPR/cas12. More...
10 Dec 2018
Image: Graph shows elevated activity of a transcription-factor network that includes the molecule onecut2 in tumors of patients whose prostate cancer resisted hormone therapy (above purple bar) compared with other types (Photo courtesy of the Nature Publishing Group).

Hormone Treatment Linked to Development of Aggressive Cancer

A team of cancer researchers has identified a gene that promotes the growth and spread of the most aggressive type of prostate cancer. More...
06 Dec 2018
Image: Skeletal formula of mannose-6-phosphate, a form of mannose that impairs   glucose metabolism (Photo courtesy of Wikimedia Commons).

Mannose Treatment Enhances Chemotherapy and Slows Growth of Cancers

Cancer researchers have found that treatment with mannose leads to growth retardation in several tumor types in vitro and in a mouse model system and enhances cell death in response to major forms of chemotherapy. More...
05 Dec 2018
Image: Toxic amyloid plaques (red) and tau tangles (brown) form on the brain of a mouse modeled to have Alzheimer\'s disease. This study shows that a DNA vaccine reduces both amyloid and tau in the mouse AD model, with no adverse immune responses (Photo courtesy of the University of Texas Southwestern Medical Center).

Novel DNA Vaccine Prevents AD in Mouse Model

A team of Alzheimer's disease (AD) researchers has shown that a DNA vaccine directed at the toxic Abeta42 peptide protected the animals comprising a mouse (AD) model from both amyloid plaques and pathogenic tau tangles. More...
04 Dec 2018
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BioResearch brings the latest research news on the genome, proteome, metabolome, on drug discovery, and therapeutics. Biotech researchers, lab administrators, technologists, drug manufacturers, and suppliers can find the latest research news and information related to their fields of endeavor here.