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BioResearch

Image: The aorta of a mouse model of atherosclerosis on a high-fat diet for 12 months (top) has significantly more plaques (bright red) than the aorta of the same type of mouse that also produces the anti-inflammatory E06 antibody (bottom) (Photo courtesy of the University of California, San Diego).

Model Demonstrates Link between Phospholipids and Atherosclerosis

A fragment of an antibody known to block the uptake of oxidized low-density lipoprotein (OxLDL) by macrophages and inhibit the proinflammatory properties of oxidized phospholipids (OxPL) was shown to prevent atherosclerosis in a mouse model. More...
19 Jun 2018
Image: A scanning electron microscopy (SEM) images confirm the deposition of an extracellular matrix, which embeds cells, presumably of both stromal and blood origins (Photo courtesy of the University of Basel).

Bone Marrow Model Promotes Growth of Blood Cell Progenitors

A recently developed culture technique has enabled researchers to establish conditions that mimic human bone marrow niches and support the maintenance of some hematopoietic stem and progenitor cell lines. More...
14 Jun 2018
Image: A ball-and-stick model of the aspirin molecule, as found in the solid state (Photo courtesy of Wikimedia Commons).

Aspirin Prevents Diseases by Controlling Nucleolar Stress

By identifying the molecular factors controlling nucleolar stress, researchers were able to outline the mechanism by which aspirin affects this stress and protects against certain disease states including colon cancer. More...
13 Jun 2018
Image: The structure of the RNase L enzyme (Photo courtesy of Wikimedia Commons).

Molecule-Based System Rids Cells of Unwanted RNAs

Researchers seeking ways to modify gene expression have developed a small-molecule-based tool that can recruit a nuclease to a specific gene transcript, triggering its destruction. More...
12 Jun 2018
Image: A scanning electron micrograph (SEM) of a human neutrophil ingesting MRSA bacteria (Photo courtesy of the U.S. National Institute of Allergy and Infectious Diseases).

Synthetic Compound Acts As Potent MRSA Killer

A synthetic compound based on lipoxazolidinone A, a small molecule isolated from bacteria living in marine sediments, was found to be a potent anti-microbial agent especially against drug-resistant bacteria such as Methicillin-resistant Staphylococcus aureus (MRSA). More...
11 Jun 2018
Image: The image shows a DNA molecule that is methylated on both strands on the center cytosine. DNA methylation plays an important role for epigenetic gene regulation in development, cancer, and some hereditary disorders (Photo courtesy of Wikimedia Commons).

Epigenetic Variation May Be Responsible for Hereditary Disorders

Genomics researchers have suggested that some hereditary disorders are caused by epigenetic variation that modifies gene expression rather than by traditional mutation that changes the sequence of DNA bases. More...
07 Jun 2018
Image: The structure of the BMI1 (B lymphoma Mo-MLV insertion region 1 homolog) protein (Photo courtesy of Wikimedia Commons).

Loss of Gene Activity Linked to Development of AD

A team of Canadian neurodegenerative disease researchers has identified a gene and its protein product that appear to be linked to the development of late-onset sporadic Alzheimer’s disease (AD), the most prevalent form of dementia. More...
06 Jun 2018
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BioResearch brings the latest research news on the genome, proteome, metabolome, on drug discovery, and therapeutics. Biotech researchers, lab administrators, technologists, drug manufacturers, and suppliers can find the latest research news and information related to their fields of endeavor here.
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