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BioResearch

Image: This artist\'s concept shows two nanoparticles coming into the brain (at top) while a pair of scissors cuts at bottom right. Use of gene editing to cut DNA at a precise location reduced autism symptoms in mice with fragile X syndrome (Photo courtesy of the University of California, Berkeley).

CRISPR/Cas9 Corrects Symptoms of Fragile X Syndrome in Model

In order to correct fragile X syndrome in a mouse model, a team of neurological disease researchers used gold nanoparticles rather than viruses to deliver the CRISP\Cas9 gene-editing tool to cells in striatum, a brain region associated with formation of habits. More...
06 Jul 2018
Image: Structure of the CFTR (cystic fibrosis transmembrane conductance regulator) protein. Mutations of the CFTR gene affecting chloride ion channel function lead to dysregulation of epithelial fluid transport in the lung, pancreas, and other organs, resulting in cystic fibrosis (Photo courtesy of Wikimedia Commons).

RNA-Based Gene Therapy Developed for Cystic Fibrosis

A potential gene therapy approach for treating cystic fibrosis utilizes lipid nanoparticle-delivered chemically modified mRNA. More...
05 Jul 2018
Image: Three-dimensional super-resolution microscopy shows that breast cancer cells (left) contain many large multivesicular bodies (green and red) that are full of exosomes ready to be released from the cell. In the absence of Munc13-4 (right), multivesicular bodies are much smaller and incapable of releasing their contents (Photo courtesy of Messenger et al., 2018).

Enzyme Elimination Blocks Exosome Release and Slows Cancer

Cancer researchers identified a molecular mechanism that enables aggressive cancer cells to manufacture and secrete large numbers of exosomes, which are critical for cancer progression and spreading. More...
04 Jul 2018
Image: Atherosclerotic lesions appear in red in this photomicrograph of a mouse aorta (Photo courtesy of Cedars-Sinai Medical Center).

Excess Inflammasome Activity Leads to Formation of Atherosclerosis

Results presented in a recently published paper explain how chronic inflammation of the arterial walls progresses to arteriosclerosis, a disorder characterized by clogged arteries and increased risk of heart attack and stroke. More...
03 Jul 2018
Image: A mixed surface–ribbon representation of the catalytic domain of human poly (ADP-ribose) polymerase 1 (PARP1) binding the small-molecule inhibitor olaparib (shown as a space-filling model) (Photo courtesy of Wikimedia Commons).

Anticancer Duo Kills Tumors While Preventing Relapse

A suggested new therapeutic approach for killing tumor cells simultaneously blocks both the PARP and RAD52 DNA repair pathways. More...
28 Jun 2018
Image: Alpha-synuclein in mitochondria of neuron (left) and single molecule TIRF image of individual alpha-synuclein aggregates (right) (Photo courtesy of Mathew Horrocks).

Development of PD Linked to Mitochondrial Damage

An international team of neurodegenerative disease researchers has suggested a mechanism that links mitochondrial damage caused by insoluble fibrils of alpha-synuclein to the development of Parkinson's disease. More...
27 Jun 2018
Image: Extracellular vesicle-like metal-organic framework nanoparticles are developed for the intracellular delivery of biofunctional proteins. The biomimetic nanoplatform can protect the protein cargo and overcome various biological barriers to achieve systemic delivery and autonomous release (Photo courtesy of the Zheng Laboratory, Pennsylvania State University).

Novel Use of Nanoparticles Developed for Targeted Drug Delivery

The innovative use of metal-organic framework nanoparticles has enabled the development of a delivery system for therapeutic proteins that selectively targets tumor cells. More...
26 Jun 2018
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BioResearch brings the latest research news on the genome, proteome, metabolome, on drug discovery, and therapeutics. Biotech researchers, lab administrators, technologists, drug manufacturers, and suppliers can find the latest research news and information related to their fields of endeavor here.
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