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BioResearch

Image: Normal human colonic crypts are pictured. SMOC-2 expression (red) in the colonic stem cells demonstrates that these cells are localized in the bottoms of the crypts. Bars represent 100 micrometers (left) and 50 micrometers (right) (Photo courtesy of the Weizmann Institute of Science).

Colon Cancer Cells Adopt Stem Cell Characteristics to Metastasize to the Liver

Cancer researchers have identified an interlocked set of enzyme activities, similar to those found in stem cells, expressed in colorectal cancer cells, which confer on these cells the enhanced cellular motility required for metastasis into the liver.  More...
12 Jul 2015
Image: In young but rapidly aging mice, high-fat diet feeding (right) ramps up heat production and metabolic activity relative to cooler mice fed a normal chow diet (left) (Photo courtesy of the Salk Institute).

High Fat Diet Corrects Mitochondrial Dysfunction in Premature Aging Mouse Model

Metabolic disease researchers used a progeroid syndrome mouse model that exhibited symptoms of mitochondrial dysfunction to demonstrate the link between mitochondrial stress and the hormone FGF21.  More...
12 Jul 2015

Analysts Expect Surge in Parkinson's Disease Treatment Market

The market for drugs to treat Parkinson's disease is expected to grow dramatically over the next several years, driven primarily by an aging population and increasing disease prevalence.  More...
12 Jul 2015
Image: Photomicrograph shows dying insulin-secreting cells (red) from a diabetic mouse pancreas. A cell-death cascade was set off by a process that occurs when harmful molecules spill from one part of the cell into other areas where they do not belong (Photo courtesy of Dr. Fumihiko Urano, Washington University School of Medicine).

Relieving Endoplasmic Reticulum Stress May Prevent Some Types of Chronic Disease

A team of cell biologists has identified an enzyme that protects cells against endoplasmic reticulum stress and prevents the apoptosis that characterizes such chronic diseases as Wolfram syndrome, diabetes, heart disease, and Parkinson's disease.  More...
08 Jul 2015
Image: Photograph (left) and optical microscopic (right) images of the new hydrogels with polyethylene glycol (PEG) microstructures developed to enable burst-free sustained-release of PEGylated protein drugs such as PEGylated interferon (Photo courtesy of A*STAR’s Institute of Bioengineering and Nanotechnology).

New Gel Extends Release Half-Life of PEGylated Drugs

Researchers have developed a first-of-its-kind hydrogel for more effective long-term drug delivery that would also reduce side-effects and discomfort for patients. Their proof-of-concept study showed effectiveness of the hydrogel with the hepatitis C drug PEGylated-interferon.  More...
08 Jul 2015
Image: During mitosis, a cell\'s chromosomes (blue) rapidly divide. When the ends of chromosomes called telomeres (green) are no longer protected by the protein TERF2, the cell receives a signal (red) to undergo cell death (Photo courtesy of the Salk Institute).

Protected Telomeres Keep Precancerous Cells from Entering the Apoptotic Pathway

A team of molecular and cell biologists has shown that potentially cancerous cells could be eliminated from the body by rendering their telomeres more susceptible to the actions of drugs that block mitosis and direct the cells onto the apoptotic pathway.   More...
08 Jul 2015
Image: A photmicrograph of medium spiny neurons (yellow) with nuclear inclusions (orange), which occur as part of the Huntington\'s disease process. Several neurons are colored yellow and have a large central core with up to two dozen tendrils branching out of them. The core of the neuron in the foreground contains an orange blob about a quarter of its diameter (Photo courtesy of Wikimedia Commons).

Seeding Assay May Boost Search for Huntington's Disease Drugs

An assay technique that measures seeding of mutant huntingtin aggregates in cerebral spinal fluid may identify individuals with Huntington's disease that have not yet become symptomatic and may be used to evaluate the efficacy of new drug treatments for the disease.  More...
07 Jul 2015
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BioResearch brings the latest research news on the genome, proteome, metabolome, on drug discovery, and therapeutics. Biotech researchers, lab administrators, technologists, drug manufacturers, and suppliers can find the latest research news and information related to their fields of endeavor here.
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