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BioResearch

Image: Plate containing E. coli producing a purple pigment indicative of low levels of zinc. The bacterium could be used to detect nutritional deficiencies in resource-limited areas of the world (Photo courtesy of Rob Felt, Georgia Institute of Technology).

Bacteria-Based Biosensor Detects Zinc Deficiency

A series of genetic engineering steps led to the development of a bacterial biosensor capable of visually distinguishing levels of zinc, a critical micronutrient.  More...
14 Sep 2015
Image: DNA damage (red) in cells submitted to replication stress, similar to those observed during stem cell reprogramming (Photo courtesy of the Spanish National Cancer Research Center).

Nucleoside Supplementation Reduces Genomic Damage in Induced Pluripotent Stem Cells

Spanish researchers have described a method to reduce the amount of genomic damage incurred during the process that transforms mature adult cells into induced pluripotent stem cells, thereby making them potentially useful for biomedical applications.  More...
14 Sep 2015
Image: A three-dimensional model of a tumor showing cell types in varying colors (Photo courtesy of Dr. Bartlomiej Waclaw and Dr. Martin A. Nowak, the University of Edinburgh).

Computer Models Help Explain How Tumors Evolve

Cancer researchers used computer modeling to create three-dimensional simulations of tumors developing over time in order to explain why the tumor mass is almost exclusively composed of one type of cell while a similar mass of normal tissue would be composed of many cell types.  More...
09 Sep 2015
Image: Fluorescence micrograph of two strains of synthetically engineered bacteria cooperating to create multicellular phenomena. The biological circuit was created by programming bacteria to alter gene expression in an entire population (Photo courtesy of Bennett Lab/Rice University).

Synthetic Biologists Create Interlinked Microbial Populations

A team of synthetic biologists has demonstrated a method for controlling how populations of microbial cells interact and regulate each other.  More...
09 Sep 2015
Image: Cancerous melanoma cells, shown with their cell bodies (green) and nuclei (blue), are nestled in tiny hollow lumens within the polymeric cryogel (red) structure (Photo courtesy of the Wyss Institute at Harvard University).

Mouse Model Shows Potential of Personalized Cancer Treatment Based on Live Cell Vaccination

A novel personalized approach to cancer immunotherapy is based on sponge-like "cryogels" that are loaded with a sampling of the patient's tumor cells together with immune system-stimulating reagents and then injected under the skin.  More...
08 Sep 2015
Image: Molecular model of CD38 (Photo courtesy of Wikimedia Commons).

Clinical Trial Confirms Potential of Candidate Antimyeloma Drug

The candidate drug daratumumab, which is a monoclonal antibody that targets the cell surface molecule CD38, was shown to be a safe and effective treatment for multiple myeloma in a combined phase I/II clinical trial.  More...
08 Sep 2015

Manipulating MicroRNA Levels May Return Cancer Cells to Normalcy

A possible approach for inducing cancer cells to revert to a precancerous state is based on the protein PLEKHA7, which regulates the levels of select microRNAs (miRNAs) to suppress expression of cell transforming factors.  More...
07 Sep 2015
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BioResearch brings the latest research news on the genome, proteome, metabolome, on drug discovery, and therapeutics. Biotech researchers, lab administrators, technologists, drug manufacturers, and suppliers can find the latest research news and information related to their fields of endeavor here.