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BioResearch

Image: An activated PTEN dimer that contains two non-mutant proteins (A) can transform the functional lipid (D) on the cellular membrane (E) into a chemical form that tunes down cancer predilection. Dimers that contain a mutated protein (B) or PTEN monomers cannot transform the functional lipid (Photo courtesy of Carnegie Mellon University).

PTEN Requires a Stable Dimer Configuration to Effectively Suppress Tumor Growth

Molecular structural analysis has shown that the PTEN tumor suppressor can function effectively only when two wild-type alleles are present to form a stable dimer that can act on lipids in the cell membrane.  More...
01 Sep 2015
Image: Middle East Respiratory Syndrome Coronavirus (MERS-CoV) particle envelope proteins immunolabeled with rabbit HCoV-EMC/2012 primary antibody and goat anti-rabbit 10 nanometer gold particles (Photo courtesy of the [US] National Institute of Allergy and Infectious Diseases).

Monkeys Protected from MERS Infection by Synthetic DNA Vaccine

A synthetic DNA vaccine directed against the Middle East Respiratory Syndrome's spike protein was found to completely protect rhesus macaques from developing pneumonia after having been exposed to the live virus.  More...
01 Sep 2015
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Pipetting Assistant Helps Prevent Repetitive Strain Injuries

A powerful pipetting accessory makes life easier for technicians in both clinical and research laboratories.  More...
01 Sep 2015
Image: Researchers engineered cultured cells to contain a red marker that moves into the nucleus upon HCV infection. Nothing happened when normal cells were exposed to HCV (top), but when the researchers expressed the protein SEC14L2, some nuclei changed color from blue to purple (bottom) (Photo courtesy of Laboratory of Virology and Infectious Disease at The Rockefeller University).

DNA Found That Enables Growth of Wild-Type Hepatitis C Virus in Cell Cultures

A team of molecular virologists has found that the overexpression of a particular DNA in liver cancer cells enables these cells to maintain the growth of wild-type Hepatitis C virus in culture.  More...
31 Aug 2015
Image: Research headed by Emory University ethnobotanist Dr. Cassandra Quave, shown collecting chestnut leaves in Italy, was inspired by traditional folk remedies (Photo courtesy of Marco Caputo).

Plant Extract Prevents Bacterial Skin Infections by Disrupting Quorum Sensing

An extract prepared from the leaves of the European chestnut Castanea sativa, a stalwart of Mediterranean region folk medicine, has been found to efficiently block the virulent effects of Staphylococcus aureus by preventing toxin production rather than by killing the organism.  More...
30 Aug 2015

MS Drug Deal to Net More Than USD 1 Billion

A pharmaceutical company based in Switzerland has purchased the remaining rights to the multiple sclerosis drug Ofatumumab, which will allow it to continue development of the compound for treating relapsing remitting multiple sclerosis and similar autoimmune diseases.  More...
30 Aug 2015
Image: Liver-on-chip device and microscopic image of bionic liver (Photo courtesy of Dr. Yaakov Nahmias, The Hebrew University of Jerusalem).

Novel Microreactor Enables Evaluation of Drug Toxicity on the Liver

A novel three-dimensional microreactor capable of maintaining metabolically active liver cells in vitro for over 28 days under stable oxygen gradients that mimic the in vivo microenvironment of the liver was used to determine why the painkiller acetaminophen causes damage to this organ.  More...
26 Aug 2015
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BioResearch brings the latest research news on the genome, proteome, metabolome, on drug discovery, and therapeutics. Biotech researchers, lab administrators, technologists, drug manufacturers, and suppliers can find the latest research news and information related to their fields of endeavor here.