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BioResearch

Researchers Define the Structure of Parkinson's Disease Protein Aggregates

The use of advanced imaging techniques has enabled biochemists to determine the molecular structure of alpha-synuclein protein fibrils such as those found in the brains of individuals with Parkinson's disease.  More...
12 Apr 2016
Image: A bone marrow aspirate smear showing precursor B-cell acute lymphoblastic leukemia cells. Chromosomal translocations and gene fusions are common in various types of leukemia (Photo courtesy of Wikimedia Commons).

Fusion Circular RNAs May Be Linked to Leukemia

The activity of noncoding circular RNAs has been linked to the development of leukemia and other cancers.  More...
12 Apr 2016
Image: This schematic illustration shows the working principle of the gold nanocage-based, photo-activated anti-bacterial drug delivery system (Photo courtesy of the University of Arkansas).

Bifunctional Gold Nanoparticles Destroy Bacterial Pathogens with Antibiotic and Thermal Killing

A team of bioengineers has designed a novel class of targeted bifunctional nanoparticles that attacks pathogenic bacteria with both antibiotic and photo-activated thermal killing strokes.  More...
12 Apr 2016
Image: Using reporter nanoparticles loaded with either a chemotherapy or immunotherapy, researchers could distinguish between drug-sensitive and drug-resistant tumors in a pre-clinical model of prostate cancer (Photo courtesy of Dr. Ashish Kulkarni, Brigham and Women\'s Hospital).

Bifunctional Anticancer Nanoparticles Deliver a Drug and Then Report Whether It Works

A novel nanoparticle-based transport system not only delivers an anticancer agent to a tumor, it reports whether the treatment is working.  More...
11 Apr 2016
Image: Pancreatic islets, shown as the lighter tissue among the darker, acinar pancreatic tissue in this hemalum-eosin stained slide (Photo courtesy of Wikimedia Commons).

Age-Related Epigenetic Changes May Lead to Development of Diabetes in Later Life

Epigenetic changes that cause increased methylation and partial or complete inactivation of genes during aging may contribute to the development of type II diabetes in older individuals.  More...
11 Apr 2016
Image: A study shows that a hollowed-out version of Cowpea mosaic virus could be useful in human therapies (Photo courtesy of the Scripps Research Institute).

New X-Ray Crystallography Study Confirms Structure of Empty Cowpea mosaic virus Particles

An X-ray crystallography study confirmed that empty Cowpea mosaic virus particles were structurally similar to the intact virus and showed that they could be used for drug transport and other biomedical applications.  More...
10 Apr 2016
Image: Ball-and-spoke three-dimensional model image of the anticancer drug romidepsin (Photo courtesy of Wikimedia Commons).

Combined Histone Deacetylase Inhibitor and Immunotherapy Shows Promise in Lung Cancer Mouse Models

A recent paper discussed how HDAC (histone deacetylase) inhibitors enhanced chemokine expression by T-cells and improved response to PD-1 immunotherapy in lung cancer.  More...
10 Apr 2016
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BioResearch brings the latest research news on the genome, proteome, metabolome, on drug discovery, and therapeutics. Biotech researchers, lab administrators, technologists, drug manufacturers, and suppliers can find the latest research news and information related to their fields of endeavor here.