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Pathology

Image: Histopathology of non-comedo breast intraductal carcinoma showing distended duct with intact basement membrane, micropapillary, and early cribriform growth pattern (Photo courtesy of Dr. Rachel Swart, MD, PhD).

New Gene Tied to Major Breast Cancer Risk

Clinical testing for genes that confer a predisposition to breast cancer has been revolutionized by next-generation sequencing and multigene panels that allow relatively inexpensive and rapid genetic profiling are now in widespread use.   More...
20 Aug 2014
Image: Histopathology of high-grade serous ovarian carcinoma (Photo courtesy of Dr. Ed Uthman, MD).

Effective Prognostic Marker Identified for Ovarian Cancer

High-grade serous ovarian carcinoma is the most prevalent of epithelial ovarian cancers and remains poorly understood due to a lack of biomarkers identified for clinical use, for diagnosis, or for prognosis of patient survival rates.  More...
20 Aug 2014
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Modern Methods Accurately Detect Cervical Cancer

The newer Papanicolaou test and human papilloma virus screening more accurately identify precancerous cellular changes that potentially develop into cervical cancer.  More...
20 Aug 2014
Image: Histopathology of clear cell renal cell carcinoma (Photo courtesy of Nephron).

Multigene Assay Predicts Cancer Patient's Survival

Patients with clear cell renal cell carcinoma have divergent survival outcomes and therapeutic responses, which may be determined by underlying molecular diversity.  More...
19 Aug 2014
Image: The photo on the left shows the entire three-in-one spectroscopy system on an easily transportable utility cart. The right photo is a close-up of the probe (Photo courtesy of the University of Texas, Austin).

Combined Spectroscopy System Rapidly Scans Skin Lesions for Cancer Signs

A team of biomedical engineers has designed an instrument for the rapid diagnosis of skin cancer that does not rely on examination of biopsy specimens.  More...
18 Aug 2014

Composition of the Gut Microbiome Differentiates Normal Individuals from Those with Precancerous Polyps or Invasive Colorectal Cancer

A recent paper described how analysis of the gut microbiome could be used to differentiate healthy individuals from those with precancerous adenomatous polyps and those with invasive colorectal cancer.   More...
18 Aug 2014
Image: Electron micrograph of human papillomavirus (HPV) (Photo courtesy of the [US] National Institutes of Health).

DNA-Based Test Predicts Likelihood of HPV-Linked Oral Cancer Recurrence

A recent paper described using a real-time quantitative polymerase chain reaction to detect human papillomavirus DNA in saliva and blood for the diagnosis of oropharyngeal squamous cell carcinoma and to predict likelihood of recurrence of the disease after treatment.   More...
13 Aug 2014
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The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.