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Pathology

Image: A diagram of the method developed to detect and map DNA methylation, which can be a sign of cancer, by threading the DNA through a tiny hole in a thin sheet of conductive material with a current running through it (Photo courtesy of Aditya Sarathy, University of Illinois).

Detecting Cancer as DNA Changes Could Enhance Diagnosis

DNA methylation is an epigenetic modification involving the addition of a methyl group to DNA, which is heavily involved in gene expression and regulation, thereby critical to the progression of diseases such as cancer. More...
26 Apr 2017
Image: A photomicrograph of abnormal cervical cells staining positive for CINtec PLUS test (Photo courtesy of Ventana Medical Systems).

Cytology Test for Pre-Cancer Diagnosis Receives FDA Approval

A cytology test, which is the only clinically validated cyclin-dependent kinase inhibitor 2A (p16) biomarker test that, when used in conjunction with hematoxylin & eosin (H&E) staining, helps pathologists determine which women should receive treatment for cervical pre-cancer. More...
25 Apr 2017
Image: High-resolution imaging with conventional confocal microscopes: by expanding brain tissue twice, researchers were able to obtain high-resolution images of neurons in the hippocampus (Photo courtesy of MIT).

High-Res Imaging Obtained with Conventional Microscopes

Researchers have developed a technique for obtaining high-resolution images of tissue samples with confocal microscopes, at a fraction of the cost of other techniques that offer similar resolution. This level of resolution allowed them to see, for example, proteins that cluster together in complex patterns at brain synapses. More...
24 Apr 2017

Urinary Volatiles Tested for Prostate Cancer Diagnosis

Early detection is one of the most important factors in helping men to survive prostate cancer, but the diagnosis is not straightforward. It usually relies on a combination of a digital rectal exam and a blood test to measure prostate-specific antigen (PSA) to help decide whether a biopsy should be done. More...
21 Apr 2017
Image: A histology of a fine needle aspiration of a lung lesion showing a three-dimensional cluster of cells with the nuclear changes of malignancy: variation in nuclear size, staining and shape, and features of squamous differentiation: moderate amount of cytoplasm, small/indistinct nucleoli, nucleus in the cell center, and keratinization (Photo courtesy of Nephron).

Blood Test Shows Cancer Recurrence Months before Scans

A prospective clinical trial showed that a blood test looking at specific biomarkers was able to detect recurrences of lung cancer an average of six months before conventional imaging methods found evidence of recurrence. More...
12 Apr 2017
Image: The cumulative incidence of dementia according to lipid concentrations (triglycerides, HDL-C, LDL-C, total cholesterol) (Photo courtesy of the University of Bordeaux).

Plasma Lipids Associated Differently with Dementia Incidents

Dementia refers to a group of neurological disorders characterized by memory loss, cognitive impairment, and disability in activities of daily living. As the primary risk factor for dementia is old age, the prevalence of dementia is increasing dramatically with aging populations worldwide. More...
12 Apr 2017
Image: A representation of the molecular structure of KDR (kinase insert domain receptor) protein (Photo courtesy of Wikimedia Commons).

Targeted Microbubbles Enhance Ultrasound Detection of Malignant Tumors

By combining standard ultrasound technology with a novel type of targeted microbubbles, cancer researchers have developed a sensitive method for detecting malignant tumors that could reduce the number of biopsies needed to differentiate them from benign growths. More...
11 Apr 2017
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The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.
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