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Pathology

Image: An ELISA Kit for Kidney Injury Molecule 1 (Kim1) (Photo courtesy of Enzo Life Sciences).

Blood Test May Help Detect Kidney Cancer Earlier

Renal cell carcinoma (RCC) has the potential for cure with surgery when diagnosed at an early stage. Kidney injury molecule-1 (KIM-1) has been shown to be elevated in the plasma of RCC patients. More...
26 Sep 2018
Image: The Aperio Scanscope XT slide scanner (Photo courtesy of University of New South Wales).

Nano-LCMS Differentiates Liver Diseases

Non-alcoholic steatohepatitis (NASH) is among the leading causes of liver disease worldwide. It is increasingly recognized that the phenotype of NASH may involve a number of different pathways, of which each could become important therapeutic targets. More...
24 Sep 2018
Image: The Oncotype DX analyzes 21 genes in the tumor to estimate a woman\'s risk of the cancer coming back after surgery (Photo courtesy of Genomic Health).

Biomarker Tests Benefit Certain Cancer Patients

The benefit of biomarker tests has been reinvestigated to support the decision for or against adjuvant systemic chemotherapy in certain breast cancer patients, that is, women with primary hormone receptor-positive, HER2/neu-negative breast cancer and 0 to 3 affected lymph nodes. More...
17 Sep 2018
Image: The Archer FusionPlex Sarcoma Kit: A targeted sequencing assay to simultaneously detect and identify fusions of 26 genes associated with soft tissue cancers (Photo courtesy of Illumina).

Targeted Sequencing Approach for Sarcoma Gene Fusions Validated

Sarcomas are rare cancers that grow in a patient's connective tissue, such as bones, muscles, tendons, nerves, and fat. Symptoms may not be apparent, since the only signs of sarcomas are lumps on a person's skin. More...
12 Sep 2018
Image: Breast tissue from a relapsed patient with active phosphorylation markers (left; brown color), compared to breast tissue from a patient without relapse and who does not have these active markers (right) (Photo courtesy of Centro Nacional de Investigaciones Oncológicas).

Prognostic Biomarkers Identified for Aggressive Breast Cancer

The rarest, but also the most aggressive and hard to treat, form of breast cancer, is known as triple negative. For this type of cancer, oncologists have so far been unable to identify markers that can classify patients by prognosis or probability of responding to different treatments. More...
11 Sep 2018
Image: The M8 serves as a dual microscope and scanner with all features accessible via a touch screen computer, making it a truly digital microscope (Photo courtesy of PreciPoint).

Colorectal Carcinoma Tumor Budding Automatically Evaluated

Tumor budding, meaning a detachment of tumor cells at the invasion front of colorectal carcinoma (CRC) into single cells or clusters has been shown to correlate to an inferior clinical outcome by several independent studies. More...
10 Sep 2018
Image: Whole-exome sequencing provides an underlying diagnosis in an efficient, cost-effective manner and incorporates analysis of newly characterized genes (Photo courtesy of Ambry Genetics).

Breast and Ovarian Cancers Associated with Predisposition Genes

Since the discovery of BRCA1 and BRCA2, multiple high- and moderate-penetrance genes have been reported as risk factors for hereditary breast cancer, ovarian cancer, or both. More...
06 Sep 2018
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The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.
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