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Pathology

Image: The XE-5000 Hematology Analyzer is a high volume analyzer that offers unique clinical parameters to aid in better patient care (Photo courtesy of Sysmex Corporation).

Prognostic Values of Platelet Parameters in Gynecological Tumors Patients

 Gynecologic cancers often involve the uterus, ovaries, cervix, vulva, vagina, fallopian tubes, or the peritoneum. The most common gynecologic cancer in the USA is endometrial cancer, followed by ovarian cancer. Many gynecologic cancers manifest as pelvic masses. More...
24 Mar 2020
Image: The IMMULITE 2000 XPi system is easy to use and has one of the largest automated immunoassay menus available. Medium- to high-volume laboratories can incorporate specialty and allergy testing into routine workloads to improve productivity and efficiency (Photo courtesy of Siemens Healthineers).

Combining Biomarkers Predicts Metastasis in Medullary Thyroid Carcinoma

 Medullary thyroid carcinoma (MTC) is a neuroendocrine neoplasm originating from thyroid parafollicular C cells and accounts for only 5% of all thyroid cancers, but its malignancy is relatively high, causing 8% to 13% of thyroid cancer‐related deaths due to its aggressiveness. More...
18 Mar 2020
Image: Schematic diagram of Neurofibromin as an Estrogen Receptor-α Transcriptional Co-repressor in Breast Cancer (Photo courtesy of Baylor College of Medicine).

Neurofibromatosis Gene and Breast Cancer Resistance to Hormone Therapy

 The cells of estrogen receptor positive (ER+) breast cancer have receptors that allow them to use the hormone estrogen to grow. Treatment with anti-estrogen hormone (endocrine) therapy can block the growth of the cancer cells. More...
17 Mar 2020
Image: Testing with combined biopsy method improves prostate cancer diagnosis (Photo courtesy of the National Institutes of Health Clinical Center).

Combined Biopsy Method Improves Prostate Cancer Diagnosis

 Prostate cancer can vary widely in severity and its potential to spread. Low-grade prostate cancer is associated with a very low risk of cancer-specific death and often does not require treatment, whereas high-grade cancers are much more likely to spread and are responsible for most prostate cancer deaths. This makes the correct assessment of the cancer grade very important for treatment decisions. More...
16 Mar 2020
Image: Histopathology showing the key features of small cell lung carcinoma (SCLC): Nuclear molding; salt and pepper chromatin; and scant cytoplasm (Photo courtesy of Nephron).

Blood-Based MicroRNA Signatures Distinguishes Individuals with Lung Cancer

 The overall low survival rate of patients with lung cancer calls for improved detection tools to enable better treatment options and improved patient outcomes. Lung cancer affects about 228,000 people a year in the USA and has a five-year survival rate just shy of 20%. More...
16 Mar 2020
Image: Histopathology showing arteries of a patient with pulmonary arterial hypertension (PAH) with marked thickening of the walls. A unique profile of gut bacteria can predict the presence of pulmonary artery hypertension in patients with 83% accuracy (Photo courtesy of Yale Rosen, MD).

Gut Bacteria Linked to Pulmonary Artery Hypertension

 Pulmonary arterial hypertension (PAH) is considered a disease of the pulmonary vasculature. Limited progress has been made in preventing or arresting progression of PAH despite extensive efforts. More...
11 Mar 2020
Image: Immunohistological micrograph showing a programmed death-ligand 1 (PD-L1) positive non-small cell lung carcinoma (Photo courtesy of Creative Commons BY-SA 4.0/Wikimedia).

Blood Test Predicts Response to Immunotherapy in Metastatic NSCLC

 Non-small cell lung cancer (NSCLC) patients with higher measures of tumor mutations that show up in a blood test generally have a better clinical response to PD-1-based immunotherapy treatments than patients with a lower measure of mutations. More...
10 Mar 2020
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The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.