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Pathology

Image: The Xevo mass spectrometer with an Acquity ultra high performance chromatography system (Photo courtesy of Waters Corporation).

Simple Urine Test Significantly Improves Detection of Adrenal Cancer

Prognosis for patients discovered to have an adrenal cortical carcinoma (ACC), a cancerous adrenal mass, is poor, and a cure is only achievable through early detection and surgery. The incidental discovery of an adrenal mass often triggers additional scans to determine whether the mass is cancerous. More...
06 Aug 2020
Image: The NovaSeq 6000 Sequencing System offers high-throughput sequencing across a broad range of applications (Photo courtesy of Illumina).

Somatic Evolution Identified in Non-Neoplastic IBD-Affected Colon

Inflammatory bowel disease (IBD) is a debilitating disease characterized by repeated flares of intestinal inflammation. The two major subtypes of IBD, Crohn’s disease (CD) and ulcerative colitis (UC) are distinguished by the location, continuity, and nature of the inflammatory lesions. More...
06 Aug 2020
Image: The Aperio AT2 is the ideal digital pathology slide scanner for high-throughput clinical laboratories, delivering precise eSlides with low rescan rate (Photo courtesy of Leica Biosystems).

Digital Pathology Solution Resolves the Tissue Floater Conundrum

In routine clinical practice, pathologists may encounter extraneous pieces of tissue on glass slides that could be because of contamination from other specimens. These are typically called tissue floaters. The dilemma pathologists often face is whether such a tissue floater truly belongs to the case in question, or if instead it represents a true contaminant from another patient’s sample in which case it should be ignored. More...
30 Jul 2020
Image: The benchtop SH800S cell sorter permits sorting of a wide range of cell sizes for many applications using the 70-μm, 100-μm, and 130-μm microfluidic sorting chips (Photo courtesy of Sony Biotechnology).

Pediatric Ependymoma Single-Cell Analysis Signatures Linked to Outcomes

An ependymoma is a tumor that arises from the ependyma, a tissue of the central nervous system. Usually, in pediatric cases the location is intracranial, while in adults it is spinal. The common location of intracranial ependymomas is the fourth ventricle. More...
30 Jul 2020
Image: FoundationOne liquid biopsy assays were used to study the association of circulating tumor DNA and circulating tumor cells after neoadjuvant chemotherapy with disease recurrence in patients with triple-negative breast cancer (Photo courtesy of Foundation Medicine).

Circulating Tumor DNA Associated with Triple-Negative Breast Cancer Recurrence

Patients with early-stage triple-negative breast cancer (TNBC) are frequently treated with neoadjuvant chemotherapy, based on the increased risk for recurrence and death associated with this category of tumors. More...
27 Jul 2020
Image: The RaDaR (Residual Disease and Recurrence) assay detects circulating tumor DNA (ctDNA) found in the bloodstream (Photo courtesy of Inivata).

CtDNA Assay for Cancer Recurrence, MRD Applications Demonstrated

Circulating tumor DNA (ctDNA) is found in the bloodstream and refers to DNA that comes from cancerous cells and tumors. Most DNA is inside a cell's nucleus. As a tumor grows, cells die and are replaced by new ones. The dead cells get broken down and their contents, including DNA, are released into the bloodstream. More...
22 Jul 2020
Image: A blue tumor organoid surrounded by red NK cells (Photo courtesy of Isaac Chan, MD, PhD).

Cancer Cells Reprogram Immune Cells to Assist in Metastasis

Natural killer (NK) cells, a type of immune cell, are known to limit metastasis by inducing the death of cancer cells, but metastases still form in patients, so there must be ways for cancer cells to escape. More...
20 Jul 2020
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Serological Pipet Controller
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Toxo IgM AccuBind ELISA Kit


The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.
Sekisui Diagnostics UK Ltd.