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Technology

Image: Schematic representation of sampling and reconstruction approach to resolve the spatial localization of genomics data (Photo courtesy of Swiss Federal Institute of Technology)

Spatial Tissue Profiled by Imaging-Free Molecular Tomography

Spatially resolved molecular atlases help scientists understand where different types of cells are located in the body and map their gene expression in specific locations in tissues and organs. However, many sequencing modalities lack spatial counterparts. More...
06 May 2021
Image: A 47-year-old man with mucormycosis and (b) electron micrograph of his skin showing sporangia of Mucorales fungi: non-apophysate sporangia with pronounced columellae and conspicuous collarette at the base of the columella following sporangiospore dispersal (Photo courtesy of IntechOpen Limited)

Different Methods Compared for Isolating Fungal DNA

Mucormycosis (previously called zygomycosis) is a serious, but rare fungal infection, caused by a group of molds called mucormycetes. These molds live throughout the environment. Mucormycosis mainly affects people who are immunocompromised or diabetic. More...
26 Apr 2021
Image: The BreathID Exalenz device (Photo courtesy of Meridian Bioscience)

Breath Test Determines Severity of Methylmalonic Acidemia Disease

Methylmalonic acidemia is a disorder in which the body cannot break down certain proteins and fats. The result is a buildup of a substance called methylmalonic acid in the blood. This condition is passed down through families and is one of several conditions called an "inborn error of metabolism." More...
20 Apr 2021
Image: Spatial and quantitative comparison of high-definition (HD) and standard definition (SD) classification performance using the 6-class model (Photo courtesy of University of Illinois at Urbana−Champaign)

Breast Cancer Histopathology Employs Infrared Spectroscopic Imaging

Digital analysis of cancer specimens using spectroscopic imaging coupled to machine learning is an emerging area that links spatially localized spectral signatures to tissue structure and disease. Breast histopathology, as an example of the broad relevance of these techniques, is critically important for clinical diagnoses. More...
19 Apr 2021
Image: The quantum dot (QD)‐based fluorescence lateral flow immunoassay (LFIA) strip can rapidly and accurately detect IL‐6 levels at different concentrations (Photo courtesy of University of South China)

Immunoassay Developed for Quantitative Detection of Serum Interleukin‐6

Interleukin‐6 (IL‐6) is a multifunctional protein and is primarily produced by macrophages, monocytes, fibroblasts, and T lymphocytes, and plays important roles in immune regulation, hematopoiesis, inflammation, and tumorigenesis. More...
07 Apr 2021
Image: The Vantera Clinical Analyzer based on nuclear magnetic resonance (Photo courtesy of Liposcience)

NMR-Based Method Measures Circulating Blood Citrate Levels

Recent studies show that citrate is involved in several biological processes such as inflammation, cancer, insulin secretion, acetylation of histones, neurological development and hydroxylglutaric aciduria, indicating that it has functions beyond energy regulation. More...
31 Mar 2021
Image: Schematic diagram for the identification of MSI status and tracing MSI+ tumors in plasma using Alu-PCR-MSI tracer (Photo courtesy of Dana-Farber Cancer Institute)

PCR Method Identifies Microsatellite Instability in Tumor-Derived Samples

Sensitive detection of microsatellite instability (MSI) in tissue or liquid biopsies using next generation sequencing (NGS) has growing prognostic and predictive applications in cancer. However, the complexities of NGS make it cumbersome as compared to established multiplex-PCR detection of MSI. More...
31 Mar 2021
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LabMedica's Lab Technology channel informs on laboratory medicine techniques, while keeping an eye on new hardware, LIM software, consumables, and lab trends, techniques and safety.