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Technology

Image: The HISCL-5000 is a fully automated immunoassay system designed for fast, highly sensitive and reliable immunoassay testing (Photo courtesy of Sysmex)

Developed Immunoassay Predicts Benefits of Anti-PD-1 Therapy in NSCLC

Lung cancer is the most common cause of cancer-related deaths worldwide. However, current targeted therapies and immunotherapies have gradually improved patient survival. Anti-programmed cell death-1 (PD-1) antibodies (Abs) are key drugs in non-small-cell lung cancer treatment; however, clinical benefits with anti-PD-1 monotherapy are limited. More...
12 May 2021
Image: Schematic of the imaging of pathological tissue 3D structure by combining optical diffraction tomography and automated stitching (Photo courtesy of Korea Advanced Institute of Science and Technology)

Holographic Histopathology Enables Fast, Precise Diagnostics

Microscopic assessment of biopsied and resected tissues is central to understanding the underlying pathophysiology and clinical states of many patients. Because most microscopic specimens are translucent to visible light, conventional histological methods achieve image contrast using exogenous labels. More...
10 May 2021
Image: Photograph of the novel capsule-based smell test (Photo courtesy of Queen Mary University of London)

A Novel Capsule-Based Smell Test for Diagnosis of Neurological and Respiratory Diseases

To aid in diagnosing diseases where loss of the sense of smell is a symptom, such as in chronic neurological conditions like Parkinson's and Alzheimer's diseases and in acute respiratory infections such as that caused by COVID-19, a team of researchers at Queen Mary University of London (United Kingdom) developed a novel smell testing kit based on capsules of aromatic oils placed between two strips of single-sided tape. More...
10 May 2021
Image: Schematic representation of sampling and reconstruction approach to resolve the spatial localization of genomics data (Photo courtesy of Swiss Federal Institute of Technology)

Spatial Tissue Profiled by Imaging-Free Molecular Tomography

Spatially resolved molecular atlases help scientists understand where different types of cells are located in the body and map their gene expression in specific locations in tissues and organs. However, many sequencing modalities lack spatial counterparts. More...
06 May 2021
Image: A 47-year-old man with mucormycosis and (b) electron micrograph of his skin showing sporangia of Mucorales fungi: non-apophysate sporangia with pronounced columellae and conspicuous collarette at the base of the columella following sporangiospore dispersal (Photo courtesy of IntechOpen Limited)

Different Methods Compared for Isolating Fungal DNA

Mucormycosis (previously called zygomycosis) is a serious, but rare fungal infection, caused by a group of molds called mucormycetes. These molds live throughout the environment. Mucormycosis mainly affects people who are immunocompromised or diabetic. More...
26 Apr 2021
Image: The BreathID Exalenz device (Photo courtesy of Meridian Bioscience)

Breath Test Determines Severity of Methylmalonic Acidemia Disease

Methylmalonic acidemia is a disorder in which the body cannot break down certain proteins and fats. The result is a buildup of a substance called methylmalonic acid in the blood. This condition is passed down through families and is one of several conditions called an "inborn error of metabolism." More...
20 Apr 2021
Image: Spatial and quantitative comparison of high-definition (HD) and standard definition (SD) classification performance using the 6-class model (Photo courtesy of University of Illinois at Urbana−Champaign)

Breast Cancer Histopathology Employs Infrared Spectroscopic Imaging

Digital analysis of cancer specimens using spectroscopic imaging coupled to machine learning is an emerging area that links spatially localized spectral signatures to tissue structure and disease. Breast histopathology, as an example of the broad relevance of these techniques, is critically important for clinical diagnoses. More...
19 Apr 2021
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LabMedica's Lab Technology channel informs on laboratory medicine techniques, while keeping an eye on new hardware, LIM software, consumables, and lab trends, techniques and safety.
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