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Image: Malaria: Thick bloods smear showing ring-form trophozoites of Plasmodium vivax that are difficult to detect. Two ring-forms are arrowed (Photo courtesy of US Centers of Diseases Control and Prevention).

Magneto-Optical Diagnosis Evaluated for Symptomatic Malaria

Malaria places a significant social and economic burden on many tropical developing countries, further undermining the potential for growth. Development of rapid, easy-to-use and low-cost malaria diagnostic methods, with high sensitivity and specificity, remains an urgent priority for tropical diseases. More...
02 Mar 2021
Image: The Pharos Micro prototype used in pulse-controlled amplification for infectious disease diagnostics (Photo courtesy of Bundeswehr Institute of Microbiology).

Pulse-Controlled Amplification Tested for Infectious Disease Diagnostics

Molecular diagnostics has become essential in the identification of many infectious and neglected diseases, and the detection of nucleic acids often serves as the gold standard technique for most infectious agents. More...
25 Feb 2021
Image: A microneedle patch has been developed that can be applied to the skin, capture a biomarker of interest from interstitial fluid and, due to its unprecedented sensitivity, allow clinicians to detect its presence (Photo courtesy of Sisi Cao).

Biosensing Microneedle Patch Quantifies Biomarkers in Interstitial Fluid

Interstitial fluid (ISF) compared with other peripheral biofluids such as saliva, sweat and tears is a particularly rich source of soluble bioanalytes including proteins, peptides, metabolites and nucleic acids that exhibit close correlation with blood. More...
10 Feb 2021
Image: The Atellica UAS800 is a completely automated urine sediment analyzer powered by advanced high-resolution digital imaging (Photo courtesy of Siemens Healthineers).

Automated Urine Microscopy Analyzer Detects Uropathogen Morphology

Urinary tract infection (UTI) is an infectious disease frequently encountered in daily life and is a representative infection that can cause serious sepsis. UTIs are very difficult to diagnose, and unnecessary treatment with antibacterial drugs of conditions with positive urine culture due to asymptomatic bacteria and vulvar‐contaminated urine is often wasteful. More...
26 Jan 2021
Image: The Microflex LT MALDI-TOF mass spectrometer and Rapid Sepsityper kit for the identification of pathogenic organisms (Photo courtesy of Bruker Daltonics).

MALDI-TOF-MS Evaluated for Rapid Diagnosis of Bacteremia and Fungemia

When sepsis occurs, it is essential to begin an effective and potent antibacterial or antifungal treatment as soon as possible as early administration and achievement of microbicidal concentrations are associated with better survival in community-acquired and hospital-acquired septicemia. More...
13 Jan 2021
Image: Schematic illustration of the immuno‐infrared sensor. Using oligoclonal capture antibodies, all TDP‐43 isoforms are extracted out of CSF (Photo courtesy of Ruhr University Bochum).

Novel Biomarker Candidate for Amyotrophic Lateral Sclerosis Explored

Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease causing a rapid loss of motor function, which usually results in a serious condition with early death within a few years. So far, early and precise diagnosis of the disease has been difficult. More...
23 Dec 2020
Image: Schematic illustration of the cantilever array to detect antibiotic resistance. (Photo courtesy of Department of Physics and Nano Imaging Lab, SNI, University of Basel).

Quick Ultra-Sensitive System Identifies Multidrug-Resistant Bacteria

The worldwide emergence of multidrug‐resistant (MDR) bacteria is associated with significant morbidity, mortality, and healthcare costs. Rapid and accurate diagnostic methods to detect antibiotic resistance are critical for antibiotic stewardship and infection control measurements. More...
22 Dec 2020
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