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Immunology

Image: The BÜHLMANN fCAL ELISA is a microtiter based assay kit for determination of calprotectin in fecal samples (Photo courtesy of Bühlmann Laboratories)

Impact of Preanalytical Factors on Calprotectin Concentration in Stool

In inflammatory bowel disease (IBD), fecal calprotectin measurement is increasingly important in selecting patients for diagnostic endoscopy, monitoring of disease activity, and evaluation of treatment response. More...
29 Dec 2022
Image: The SFRI IRE 96 is a simple and robust ELISA Absorbance Microplate Reader finds application in ELISA assays (Photo courtesy of HealthManagement.org)

Antiphospholipid Antibodies in Patients With Unexplained Articular Manifestations

Joint pain is the most common chronic pain making it one of the largest causes of disabilities in the world. Arthritis is a frequent condition that causes edema, redness, heat, loss of function and pain. It can affect one or more joints and there exist more than 100 different types. More...
21 Dec 2022
Image: The Cobas Е 801 Analyzer analytical unit is a high throughput immunochemistry module that performs a broad range of heterogeneous immunoassay tests (Photo courtesy of Dialogue Diagnostics LLC)

CSF Immunoassays Aid Diagnosis of Early Alzheimer’s Disease

The pathological processes underlying Alzheimer’s disease (AD) begin many years before clinical presentation. Ongoing drug discovery efforts in AD focus on developing disease-modifying treatments aiming to delay onset or progression of dementia and must be initiated early in the disease process. More...
21 Dec 2022
Image: A T cell receptor that recognizes a human protein fragment (left) is remarkably similar to one that recognizes a bacterial protein fragment (right), and to two receptors capable of recognizing both human and bacterial protein fragments (middle) (Photo courtesy of Washington University School of Medicine)

Autoimmunity-Associated T Cell Receptors Recognize HLA-Variant-Bound Peptides

The immune response in autoimmune disease recapitulates that of responses directed against infection, except that self-antigens are, or become, the target of the adaptive immune system. These self-antigens may drive a process that is localized within a specific organ, such as the thyroid gland (Grave’s disease, Hashimoto’s thyroiditis) or brain (multiple sclerosis). More...
13 Dec 2022
Image: Endomyocardial biopsy showing lymphocytic myocarditis (Photo courtesy of Marion University)

Blood Test for Myocarditis Detects Heart Inflammation

Myocarditis is a difficult condition to diagnose. Symptoms include a temperature, fatigue, chest pain and shortness of breath, which can all be easily mistaken for other conditions. The gold standard method for diagnosis is a heart biopsy, an expensive, invasive, and risky procedure which can sometimes still miss signs of the condition. More...
05 Dec 2022
Image: Antiphospholipid Antibodies Evaluated in Autoimmune Thyroid Diseases (Photo courtesy of VisitHealth limited)

Antiphospholipid Antibodies Evaluated in Autoimmune Thyroid Diseases

Autoimmune thyroid diseases (AITD) is the most common organ-specific autoimmune disease, mainly caused by genetic predisposition, environmental factors and dysfunction in the microbiome. More...
29 Nov 2022
Image: Enzyme-linked immunosorbent assay were used to measure serum levels of IL-37, IL-38, and Vitamin D (Photo courtesy of MyBioSource Inc)

Interleukins and Vitamin D Evaluated in Women With Graves' Disease

Graves' disease (GD), an autoimmune disorder specific to the thyroid, is the leading cause of hyperthyroidism due to an enlarged and hyperactive thyroid gland, associated with extra-thyroidal manifestations, such as orbitopathy and pretibial myxedema. More...
23 Nov 2022
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The Immunology channel of LabMedica deals with diagnostic techniques and immuonassays such as ELISA, pregnancy tests, immunoblotting, immunohistochemical staining, serology, and associated hardware.