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Immunology

Image: The AutoDELFIA 1235 is an automatic immunoassay system (Photo courtesy of PerkinElmer Life Sciences)

High-Capacity Serological Assay Developed for Celiac Disease

Celiac disease is a chronic inflammatory disorder of the small intestinal mucosa occurring in genetically predisposed individuals exposed to dietary gluten proteins of wheat (gliadin and glutenin), barley (hordein) or rye (secalin) origin. More...
02 Sep 2022
Image: The BioIC Allergen Specific-IgE Detection Kit-AD 40 panel (Photo courtesy of Agnitio Science and Technology).

Cord Blood IgE Levels Tied To Allergy, Asthma Rates

The rising prevalence of allergic diseases worldwide represents an important health problem. Early identification of children at high risk of allergic diseases could be helpful for physicians to recommend preventive measures and apply early interventions. More...
22 Aug 2022
Image: The Attune NxT Flow Cytometer is ideal for immunophenotyping and signaling studies, cell cycle analysis, detection of rare events, stem cell analysis, cancer and apoptosis studies, microbiological assays and more (Photo courtesy of Thermo Fisher Scientific).

Blood Abnormalities Found in People with Long Covid

SARS-CoV-2 infection can result in the development of a constellation of persistent sequelae following acute disease called post-acute sequelae of COVID-19 (PASC) or Long COVID. More...
22 Aug 2022
Image: Representative GPC3 expression by IHC: Immunohistochemical staining of (A) normal skin and (B) MCC tumors for GPC3 expression. Representative images with different levels of GPC3 (and H-scores) are shown (Photo courtesy of University Hospital of Tours)

Glypican-3 Is Associated With Impaired Outcome in Merkel Cell Carcinoma

Merkel cell carcinoma (MCC) is a rare and aggressive neuroendocrine skin cancer mostly occurring in elderly patients, with increased incidence in case of immunosuppression. MCC is related to the Merkel Cell Polyomavirus (MCPyV) in 80% of cases. Immune checkpoint inhibitors provide sustained benefit in about 50% of MCC patients with advanced disease. More...
16 Aug 2022
Image: The SpectraMax plus microplate reader was used to show that regulatory T cells in erythema nodosum leprosum maintain anti-inflammatory function (Photo courtesy of Molecular Devices)

Regulatory T Cells in Leprosy Maintain Anti-Inflammatory Function

Leprosy is caused by Mycobacterium leprae, an intracellular acid-fast bacillus and is complicated by episodes of inflammation called leprosy reactions. Leprosy reactions are important causes of nerve damage and illness. More...
10 Aug 2022
Image: Photomicrograph of Treponema pallidum bacterial spirochetes, which exhibited their characteristic corkscrew shape using the dark field visualization technique (Photo courtesy of Louisa Lu, MD)

Recombinant Antigens Assessed for Serological Diagnosis of Syphilis

Syphilis is a chronic multisystemic disease caused by infection with the spirochete Treponema pallidum and acquired usually via sexual exposure or via vertical mother–fetus transmission or by blood transfusions. An estimated 18 million cases worldwide and 5.6 million new cases occur annually. More...
09 Aug 2022
Image: Maternal Fc-mediated non-neutralizing antibody responses correlate with protection against congenital human cytomegalovirus infection (Photo courtesy of Weill Cornell School of Medicine).

Maternal Antibodies Can Protect Infants from Cytomegalovirus

Human cytomegalovirus (HCMV) is the most common congenital infection and a leading cause of stillbirth, neurodevelopmental impairment, and pediatric hearing loss worldwide. Antibodies that summon virus-engulfing white blood cells may play an important role in protecting infants from potentially serious congenital infection with HCMV. More...
26 Jul 2022
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The Immunology channel of LabMedica deals with diagnostic techniques and immuonassays such as ELISA, pregnancy tests, immunoblotting, immunohistochemical staining, serology, and associated hardware.
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